Retrospective Case-Control Study of Risk Factors for Carbapenem-Resistant Klebsiella pneumoniae Infection in Children in China DOI Creative Commons

C Wang,

Lijie Feng,

Ruomu Chen

et al.

Pathogens, Journal Year: 2024, Volume and Issue: 13(12), P. 1106 - 1106

Published: Dec. 14, 2024

This study aims to investigate the risk factors for infection and mortality associated with carbapenem-resistant Klebsiella pneumoniae (CRKP) in hospitalized children, goal of providing valuable insights prevention treatment these bacterial infections. A retrospective case-control was conducted, including 153 cases carbapenem-sensitive K. children 49 CRKP infection. Among cases, 40 survived nine died. Logistic regression analysis used screen establish a predictive model, analyze CRKP-infected children. The results multivariate showed that hematopoietic malignancies (OR = 28.272, 95% CI: 2.430-328.889), respiratory tract infections 0.173, 0.047-0.641), mechanical ventilation 3.002, 1.117-8.071), number antibiotic agents 1.491, 1.177-1.889), WBC 0.849, 0.779-0.926), neutrophil count 0.779, 0.677-0.896) were identified as significant Specifically, history multiple hospitalizations within past three months, blood stream infections, decreased lymphocyte counts should be monitored closely due poor prognosis. Underlying non-respiratory after admission, use antibiotics without increase white cell are major influencing Particularly, no potential severity illness.

Language: Английский

Evaluating the Risks of Heated Tobacco Products: Toxicological Effects on Two Selected Respiratory Bacteria and Human Lung Cells DOI Creative Commons
Salvatore Furnari, Rosalia Emma, Massimo Caruso

et al.

Toxics, Journal Year: 2025, Volume and Issue: 13(2), P. 70 - 70

Published: Jan. 21, 2025

Heated tobacco products (THPs) are increasingly promoted as potential harm reduction tools, offering an alternative to traditional cigarettes. Despite these claims, understanding of their toxicological impact on respiratory health and associated microbial communities is limited. Comprehensive investigations needed elucidate the biological mechanisms implications with use. Methods: This study evaluated effects aerosols produced by THPs (IQOS 3 Duo Heets “Sienna Selection”) in comparison conventional cigarette smoke (1R6F). Antibacterial activity was using Streptococcus pneumoniae Klebsiella representative species microbiota through agar diffusion assays MIC/MBC determinations. Cytotoxicity assessed human lung fibroblast cells (MRC5) neutral red uptake (NRU) assay, whereas mutagenicity investigated Ames test. Results: THP demonstrated ability inhibit growth both S. K. pneumoniae, exerting bacteriostatic at lower concentrations bactericidal higher concentrations. While antibacterial might initially seem beneficial against pathogens such they raise concerns about disruption balance, particularly relation pneumoniae. microbiological effects, minimal cytotoxicity fibroblasts lacked detectable mutagenic activity, contrasting significant caused smoke. Conclusions: present a reduced short-term profile compared cigarettes; however, microorganisms deserve attention. The observed inhibition commensal bacteria highlights need explore changes ecosystem that could affect health. These findings highlight for additional studies evaluate long-term effect use stability overall ecosystem.

Language: Английский

Citations

0
Prediction of fatal outcome in patients with pneumonia caused by carbapenem-resistant Klebsiella pneumoniae DOI
К. В. Левченко, В. М. Мицура

Medical and Biological Problems of Life Activity, Journal Year: 2025, Volume and Issue: 1, P. 89 - 94

Published: April 27, 2025

Pneumonia caused by carbapenem-resistant K. pneumoniae often has a severe course and significant risk of unfavorable outcome. Various scales indices have been proposed for timely assessment the patient's condition detection high For attending physician, ease use prognostic accuracy index used in are important. The aim study was to evaluate diagnostic significance clinical laboratory parameters predicting fatal outcome patients with pneumonia pneumoniae. A total 71 cases multiple extreme drug resistance were retrospectively analyzed. Two groups formed depending on outcome: group 1 – 41 discharged from hospital upon completion treatment; 2 30 structure concomitant diseases, body mass (BMI), blood saturation (SpO ), hemogram parameters, C-reactive protein (CRP) It found that characterized higher leukocyte counts, neutrophils hemogram, neutrophil/lymphocyte ratio (NLR), CRP, BMI; lower lymphocyte SpO2. most indicators an lymphocytes, neutrophils, NLR, BMI. To predict death, we (BMI*NLR)/SpO . ROC analysis performed: AUC 0,99 (0,93–1,00), test sensitivity 100,0 %, specificity 97,6 % at cutoff point > 1,53, Youden 0,98. Diagnostic value (at threshold 1,53): is 95,1 positive predictive 93,8 negative 97,2 %. level 1,53) may be preferable pneumoniae, due its (100 %) (97,6 %), as well use.

Language: Английский

Citations

0
Management practices and mortality predictors among Klebsiella pneumoniae infections across Lebanese hospitals: a multicenter retrospective study DOI Creative Commons
Rania Itani, Hani M. J. Khojah,

Hamza Raychouni

et al.

BMC Infectious Diseases, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 28, 2025

Language: Английский

Citations

0
A Decade-Long Review of the Virulence, Resistance, and Epidemiological Risks of Klebsiella pneumoniae in ICUs DOI Creative Commons
Tao-An Chen,

Ya-Ting Chuang,

Chieh-Hui Lin

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(12), P. 2548 - 2548

Published: Dec. 11, 2024

Klebsiella pneumoniae, a major opportunistic pathogen, causes severe infections in both community and healthcare settings, especially intensive care units (ICUs), where multidrug-resistant (MDR) strains, such as carbapenem-resistant K. pneumoniae (CRKP), pose significant treatment challenges. The rise hypervirulent (hvKP) with enhanced virulence factors complicates management further. ST11 clone, prevalent China, exhibits resistance traits, contributing to hospital outbreaks. ICU patients, particularly those comorbidities or prior antibiotic exposure, are at higher risk. Treatment is complicated by limited options the increasing prevalence of polymicrobial infections, which involve resistant pathogens like Pseudomonas aeruginosa Acinetobacter baumannii. Combination therapies offer some promise, but mortality rates remain high, last-resort antibiotics growing. Infection control measures personalized plans critical, alongside urgent need for vaccine development combat rising threat vulnerable populations. Effective requires improved diagnostic tools, antimicrobial stewardship, innovative strategies reduce burden this resource-limited settings. This review aims provide comprehensive analysis virulence, resistance, epidemiological risks ICUs over past decade, highlighting ongoing challenges continued efforts growing threat.

Language: Английский

Citations

2
Retrospective Case-Control Study of Risk Factors for Carbapenem-Resistant Klebsiella pneumoniae Infection in Children in China DOI Creative Commons

C Wang,

Lijie Feng,

Ruomu Chen

et al.

Pathogens, Journal Year: 2024, Volume and Issue: 13(12), P. 1106 - 1106

Published: Dec. 14, 2024

This study aims to investigate the risk factors for infection and mortality associated with carbapenem-resistant Klebsiella pneumoniae (CRKP) in hospitalized children, goal of providing valuable insights prevention treatment these bacterial infections. A retrospective case-control was conducted, including 153 cases carbapenem-sensitive K. children 49 CRKP infection. Among cases, 40 survived nine died. Logistic regression analysis used screen establish a predictive model, analyze CRKP-infected children. The results multivariate showed that hematopoietic malignancies (OR = 28.272, 95% CI: 2.430-328.889), respiratory tract infections 0.173, 0.047-0.641), mechanical ventilation 3.002, 1.117-8.071), number antibiotic agents 1.491, 1.177-1.889), WBC 0.849, 0.779-0.926), neutrophil count 0.779, 0.677-0.896) were identified as significant Specifically, history multiple hospitalizations within past three months, blood stream infections, decreased lymphocyte counts should be monitored closely due poor prognosis. Underlying non-respiratory after admission, use antibiotics without increase white cell are major influencing Particularly, no potential severity illness.

Language: Английский

Citations

0