Worldwide burden and cross-regional health inequalities of high BMI-attributable colorectal cancer by gender from 1990 to 2021, with predictions through 2041 DOI Creative Commons
Jinhai Zhang, Jingge Yang

BMC Gastroenterology, Journal Year: 2025, Volume and Issue: 25(1)

Published: May 20, 2025

Language: Английский

Global, regional, and national epidemiology of ischemic heart disease among individuals aged 55 and above from 1990 to 2021: a cross-sectional study DOI Creative Commons
Peng Xue, Ling Lin, Peishan Li

et al.

BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 12, 2025

The findings of the 2021 Global Burden Disease (GBD) study can offer valuable insights for development screening and prevention strategies targeting ischemic heart disease (IHD). We aim to investigate trends in IHD incidence, mortality, disability-adjusted life years (DALYs), while exploring associated risk factors IHD-associated death from 1990 2021. cross-sectional utilized data GBD 2021, covering 204 countries regions. analysis included individuals aged 55 above. analyzed all cause cause-specific deaths, DALYs, corresponding estimated annual percentage changes (EAPCs) These indicators were further stratified by geographical region, country, age group, gender, sociodemographic index (SDI). global incidence rate, mortality DALYs rate above with have shown a decreasing trend. However, number incident cases, has been increasing Both high-middle high SDI regions exhibit significant decline these rates low SDI, low-middle middle show less noticeable changes. region experiences largest increase (EAPC: 0.38; 95%CI, 0.33–0.44) 0.17; 0.12–0.22). 0.37; 0.27–0.46). Regionally, East Asia exhibits greatest 0.94; 95% CI, 0.79–1.10), 1.68; 1.40–1.94), 0.69–1.20). Among 12 IHD, systolic blood pressure, dietary risks, low-density lipoprotein (LDL) cholesterol levels, air pollution are identified as primary contributors mortality. This reveals that regions, declining. Conversely, burden is increasing. It highlights inequality burden. Recommendations include early screening, management, strengthening care, especially Countries should also invest environmental governance control. Future research focus on evaluating effects health policies different countries, impact socio-economic cultural developing big data-based prediction models optimize resource allocation intervention strategies.

Language: Английский

Citations

1
Global Burden Of Cancer Among Women Of Child-Bearing Age From 1990 To 2021: Insights From The Global Burden Of Disease Study 2021 DOI
Yunhai Chuai, Xiaoli Zhang, Wen Jiang

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Burden and risk factors of colorectal cancer in Europe from 1990 to 2021 DOI
Tao Zhang, Shuai Wang, Dongming Li

et al.

European Journal of Cancer Prevention, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 18, 2025

Background Colorectal cancer (CRC) poses a significant health burden in Europe, but comprehensive studies on this region are limited. Methods Using data from the Global Burden of Diseases (GBD), Injuries, and Risk Factors Study 2021, we analyzed regional distribution temporal trends CRC early-onset Europe 1990 to 2021. Decomposition analysis was applied quantify contributions population growth, aging, epidemiological changes. The research also evaluated major risk factors associated with CRC. Results found be higher than global average. While age-standardized incidence rate (ASIR) increased, both mortality (ASMR) disability-adjusted life years (ASDR) decreased. Early-onset exhibits similar characteristics patterns change. Males had significantly females. Population aging primary driver increased Europe. factor revealed that low whole grain intake high red meat consumption were contributors elevated ASMR ASDR Additionally, BMI fasting plasma glucose showed an increasing trend. Conclusion overall remains level, ASIR decreasing ASDR. Targeted prevention control strategies should developed based for Older adults men prioritized interventions.

Language: Английский

Citations

0
Global burden of cancer among women of child-bearing age from 1990 to 2021: insights from the Global Burden of Disease Study 2021 DOI Creative Commons
Yunhai Chuai, Xiaoli Zhang, Wen Jiang

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

Abstract Background：Malignant neoplasm is one of the leading durden diseases worldwide, particularly among women child-bearing age (WCBA) with a significant higher incidence rate than their male counterparts. This study aimed to assess burden and trend cancers WCBA from 1990 2021. Methods: This retrieved data Global Burden Disease Study (GBD) 2021 on incidence, prevalence, disability adjusted life-years (DALYs) 30 Estimated annual percentage changes (EAPC) change, by socio-demographic index (SDI), were calculated quantify temporal trends. Spearman correlation analysis was used examine between burdens SDI. Results: Our results showed that breast, cervical, ovarian, colon/rectum, thyroid, uterine, tracheal/bronchus/lung, brain/central nervous system (CNS), stomach, non-Hodgkin lymphoma, leukemia, malignant skin melanoma had highest global rates respectively in From 2021, prevalence thyroid, brain/CNS an upward trend, while stomach cancer leukemia significantly declined. In terms SDI regions, high high-middle regions DALYs rstes brain/CNS, melanoma, middle low thyroid lymphoma. Age distribution indicated major increased age, peaking 45 49 group. Conclusion: reveals regional characteristics highlights important impact socio-economic factors burden. The findings provide scientific basis for developing prevention control strategies, especially specific groups.

Language: Английский

Citations

0
Exploring the Impact of Chemotherapy on the Emergence of Antibiotic Resistance in the Gut Microbiota of Colorectal Cancer Patients DOI Creative Commons

Mutebi John Kenneth,

Chin‐Chia Wu,

Chuan‐Yin Fang

et al.

Antibiotics, Journal Year: 2025, Volume and Issue: 14(3), P. 264 - 264

Published: March 5, 2025

With nearly half of colorectal cancer (CRC) patients diagnosed at advanced stages where surgery alone is insufficient, chemotherapy remains a cornerstone for this treatment. To prevent infections and improve outcomes, antibiotics are often co-administered. However, chemotherapeutic interactions with the gut microbiota cause significant non-selective toxicity, affecting not only tumor normal epithelial cells but also microbiota. This toxicity triggers bacterial SOS response loss microbial diversity, leading to mutations dysbiosis. Consequently, pathogenic overgrowth systemic increase, necessitating broad-spectrum intervention. review underscores how prolonged antibiotic use during chemotherapy, combined chemotherapy-induced mutations, creates selective pressures that drive de novo antimicrobial resistance (AMR), allowing resistant bacteria dominate gut. compromises treatment efficacy elevates mortality risk. Restoring diversity may mitigate therapeutic emerging strategies, such as fecal transplantation (FMT), probiotics, prebiotics, show considerable promise. Given global threat posed by treatment, prioritizing stewardship essential optimizing preventing in CRC undergoing chemotherapy. Future research should aim minimize chemotherapy’s impact on develop targeted interventions restore affected

Language: Английский

Citations

0
Neoadjuvant therapy for colorectal cancer from 2015 to 2024: a visual analysis and bibliometric analysis DOI Creative Commons

Boyu Kang,

Yihuan Qiao,

Junyong Zhu

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: April 2, 2025

Colorectal cancer (CRC) imposes a substantial burden on global health., but research trends and hotspots in this field are still not clear. The purpose of is to create visual knowledge map based bibliometric analysis, identify predict future trends. Utilizing the Web Science Core Collection (WoSCC) as data source integrating visualization capabilities Bibliometrix R software package, CiteSpace, VOSviewer, analyze authors, institutions, countries, cited documents, publishing journals, abstracts, keyword information literature pertaining neoadjuvant therapy for colorectal spanning from January 2015 December 2024. analysis included 1,587 articles 1,464 385 61 countries or regions. China has largest number publications (449) citations (5,035). United States occupies leading position with an average 21.6. "Annals Surgical Oncology" most published journal 51 articles, "Journal Clinical references (4,465 references). Highly focus clinical trials guidelines cancer. In recent years, important keywords have been "artificial intelligence", "total therapy" "immunotherapy". This article provided review cancer, can provide reference subsequent results offered valuable insights that informed direction advancements.

Language: Английский

Citations

0
Worldwide burden and cross-regional health inequalities of high BMI-attributable colorectal cancer by gender from 1990 to 2021, with predictions through 2041 DOI Creative Commons
Jinhai Zhang, Jingge Yang

BMC Gastroenterology, Journal Year: 2025, Volume and Issue: 25(1)

Published: May 20, 2025

Language: Английский

Citations

0