A negative correlation of low estimated glucose disposal rate with significant liver fibrosis in adults with NAFLD and obesity: results from NHANES 2017–2020 DOI Creative Commons
Xuecheng Tong, Kai Liu, Junying Xu

et al.

BMC Gastroenterology, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 29, 2025

Abstract Background and aim Nonalcoholic fatty liver disease (NAFLD) with fibrosis is associated liver-related mortality cardiovascular disease. Estimated glucose disposal rate (eGDR), which an insulin resistance–related index, related to the caused by NAFLD. This study aimed investigate predictive value of eGDR for in patients Methods The data from National Health Nutrition Examination Survey 2017–2020.03 were analyzed present study. NAFLD was diagnosed using controlled attenuation parameter (CAP) tests FibroScan ® model 502 V2 Touch. Results 1585 individuals analyzed, including 224 significant 1361 nonsignificant fibrosis. Individuals older had higher CAP values lower eGDRs (both P < 0.01). A negative correlation found between stiffness degrees (odds ratio: 0.643, 95% confidence interval: 0.643–0.726, 0.001); also after adjusting age, sex, ethics ( 0.001). For participants obesity overweight, negatively correlated CAP, body mass index (BMI), waist circumference, C-reactive protein level, white blood cell (WBC) count (all 0.05). multivariate analysis revealed that eGDR, BMI, aspartate aminotransferase (AST), WBC platelet (PLT) counts 0.05) independent risk factors incorporating AST, WBC, PLT AUROC 0.822, superior conventional noninvasive scoring systems, AST-to-PLT ratio fibrosis-4 gamma-glutamyl transpeptidase Conclusion Low obesity, a demonstrated strong evaluation.

Language: Английский

A negative correlation of low estimated glucose disposal rate with significant liver fibrosis in adults with NAFLD and obesity: results from NHANES 2017–2020 DOI Creative Commons
Xuecheng Tong, Kai Liu, Junying Xu

et al.

BMC Gastroenterology, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 29, 2025

Abstract Background and aim Nonalcoholic fatty liver disease (NAFLD) with fibrosis is associated liver-related mortality cardiovascular disease. Estimated glucose disposal rate (eGDR), which an insulin resistance–related index, related to the caused by NAFLD. This study aimed investigate predictive value of eGDR for in patients Methods The data from National Health Nutrition Examination Survey 2017–2020.03 were analyzed present study. NAFLD was diagnosed using controlled attenuation parameter (CAP) tests FibroScan ® model 502 V2 Touch. Results 1585 individuals analyzed, including 224 significant 1361 nonsignificant fibrosis. Individuals older had higher CAP values lower eGDRs (both P < 0.01). A negative correlation found between stiffness degrees (odds ratio: 0.643, 95% confidence interval: 0.643–0.726, 0.001); also after adjusting age, sex, ethics ( 0.001). For participants obesity overweight, negatively correlated CAP, body mass index (BMI), waist circumference, C-reactive protein level, white blood cell (WBC) count (all 0.05). multivariate analysis revealed that eGDR, BMI, aspartate aminotransferase (AST), WBC platelet (PLT) counts 0.05) independent risk factors incorporating AST, WBC, PLT AUROC 0.822, superior conventional noninvasive scoring systems, AST-to-PLT ratio fibrosis-4 gamma-glutamyl transpeptidase Conclusion Low obesity, a demonstrated strong evaluation.

Language: Английский

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