Association of oxidative balance score and all-cause and cardiovascular mortality in patients with hyperuricemia and gout

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 24, 2025

Background Hyperuricemia and gout are metabolic disorders associated with an increased risk of all-cause cardiovascular mortality. Oxidative stress plays a crucial role in their pathogenesis, dietary lifestyle modifications may offer protective benefits. The Balance Score (OBS), integrative measure oxidative balance, has been linked to chronic disease outcomes. However, its association mortality individuals hyperuricemia remains unclear. This study aims investigate the relationship between OBS patients gout, using data from National Health Nutrition Examination Survey (NHANES) 1999–2018. Methods A total 6,178 non-pregnant adults (aged 20–79 years) or were included NHANES. was calculated based on 16 components 4 factors, higher scores indicating greater antioxidant exposure. Mortality status ascertained through linkage Death Index (NDI) until December 31, 2019. Cox proportional hazards models used examine (CVD) mortality, adjusting for demographic, socioeconomic, clinical covariates. Sensitivity analyses conducted assess robustness, including stratified by smoking exclusion early deaths pre-existing CVD cases. Results During median follow-up 8.17 years (52,496 person-years), 970 recorded, 327 CVD-related deaths. Higher significantly lower risk. In fully adjusted model, each unit increase 2% reduction (HR 0.98, 95% CI 0.96–0.99) 3% 0.97, 0.95–0.99). Compared participants lowest quartile (Q1), those highest (Q4) had 47% 0.53, 0.40–0.69) 59% 0.41, 0.25–0.67). Kaplan-Meier survival analysis restricted cubic splines confirmed inverse, score-dependent (p-overall < 0.001). Stratified showed that inverse weaker current smokers, suggesting potential interactions pathways (p-interaction = 0.03). further supported robustness findings, cases yielding consistent results. Conclusion provides strong epidemiological evidence is gout. These findings highlight benefits antioxidant-rich diet healthy reducing among this population. Future longitudinal studies interventional trials warranted confirm these associations explore underlying biological mechanisms.

Language: Английский

Kidneys: uromodulin and hyperuricemia

KIDNEYS, Journal Year: 2025, Volume and Issue: 14(1)

Published: March 11, 2025

Background. Uromodulin (Umod) has a significant impact on the development and course of chronic kidney disease (CKD). For example, higher Umod level is associated with lar­ger size estimated glomerular filtration rate (eGFR). excretion known to be fractional excretions uric acid, chloride, sodium (markers volume overload), but relationship between hyperuricemia not yet fully understood. The purpose study: investigate blood acid levels in patients CKD stage I–III. Materials methods. A prospective randomized cohort ROLUNT (uROmoduLin, UbiquinoNe, glutaThione) study which 34 greater than 360 μmol/L participated was conducted 2021–2023. ­ROLUNT carried out at ­VETA-PLUS LLC Brovary Multidisciplinary Clinical Hospital, are clinical bases Department Nephrology Renal Replacement Therapy Shupyk National Healthcare University Ukraine. Results. results Spearman’s correlation showed that there large positive relationship: (FeUmod) risk index for terminal after 2 (QxMD2) 5 years (QxMD5); Charlson Comorbidity Index, creatinine (sCrea), urea nitrogen (BUN), (sUrea), low-density lipoprotein (LDL), total cholesterol (sChol), urine (uUmod)/eGFR according ­CKD-EPI formula (eGFRCKD), uUmod/urine (uCrea), urinary albumin (uAlb)/uCrea; uAlb/uUmod uAlb, uAlb/uCrea; daily uUmod (uUmod24) uUmod, uUmod/Umod (sUmod), body mass index; uUmod/sUmod uUmod24; uUmod/uCrea uAlb/uCrea, uUmod/eGFRCKD, FeUmod, sChol, LDL, very low density lipoprotein, percentage adipose tissue, sUrea, BUN, BUN/sCrea, sUrea/sCrea, QxMD2, QxMD5; uUmod/eGFRCKD uUmod/uCrea, sCrea, QxMD5. Conclusions. wide range effects only system makes it an important biomarker practice nephrologists doctors other specialties.

Language: Английский