Exploring the nonlinear relationship between serum uric acid to high-density lipoprotein cholesterol ratio and obesity in older adults: a cross-sectional study

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 13

Published: May 1, 2025

The prevalence of obesity, a common metabolic disorder, has been increasing annually, particularly in older adults. This trend poses significant socioeconomic burden. uric acid to high-density lipoprotein cholesterol ratio (UHR) was defined by dividing UA (mg/dL) HDL-C and multiplying 100%. According recent clinical research, UHR emerged as potential innovative indicator status evaluation, supported contemporary biomarker research. cross-sectional study investigated the association between index obesity among Americans. research employed nationally representative survey data Examine connection individuals aged 60 above. utilized from National Health Nutrition Examination Survey (NHANES) spanning 2011 2016. Individuals who were years old or included (n = 3,822). relationship levels (as measured body mass 30 kg/m2 greater waist-to-height (WHtR) ≥0.5) using weighted multivariable logistic regression analyses, with adjustments made for sociodemographic characteristics, behavioral patterns, covariates, adjusting sociodemographic, behavioral, covariates. Restricted cubic spline, ROC curves, threshold analysis, subgroup analysis also used. After full adjustment confounders, positively associated risk BMI (highest quartile vs. lowest quartile: OR 6.13, 95% CI 4.01-9.39; P-trend < 0.001) WHtR 20.21, 8.33-49.02; p-trend 0.001). In addition, restricted spline uncovered nonlinear dose-response (P 0.01), found inflection points -2.485 -2.503 WHtR. Subgroup analyses showed that Americans consistent across subgroups, demonstrating high reliability (all P-interaction > 0.05). AUC predicting calculated be 0.65 (95% 0.63-0.66). predicted men's (BMI) 0.67 0.65-0.70). an 0.69 0.67-0.72) females. 0.75 0.72-0.78). 0.76 0.72-0.80) males, 0.83 0.79-0.87) findings demonstrate notable positive correlation adults, this remaining evident following multiple confounding variables. These results imply systematic evaluation could serve effective strategy proactively detecting populations susceptible obesity-related disorders.

Language: Английский

Association of body roundness index with uterine fibroids in women of childbearing age: a cross-sectional analysis of NHANES 1999–2006

Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)

Published: May 3, 2025

Language: Английский