Evaluation of Triglyceride-Glucose (TyG) Index in Individuals Living with HIV Under Antiretroviral Therapy (ART)
Abstract
Introduction:
Fasting
triglyceride-glucose
(TyG)
index,
which
indirectly
evaluates
insulin
resistance,
is
an
important
risk
parameter
in
various
diseases,
especially
cardiovascular
diseases
(CVD).
There
are
very
limited
number
of
studies
evaluating
TyG
index
individuals
living
with
HIV,
where
the
incidence
these
increased.
This
study
was
conducted
to
determine
change
during
first
year
antiretroviral
therapy
and
relationship
between
CD4/CD8
ratio.
Methods
Data
patients
HIV
who
were
followed
up
2011
2024
retrospectively
analyzed.
348
ART-naive,
non-diabetic
completed
their
follow-up
under
ART
included
study.
calculated
according
formula
Ln
[fasting
triglyceride
(mg/dL)
x
fasting
glucose
(mg/dL)/2].
Patients
TG
values
>150
mg/dl
at
time
diagnosis
constituted
hypertriglyceridemic
(HTG)
group,
≤150
non-hypertriglyceridemic
(NHTG)
group.
Results
Hypertriglyceridemia
detected
146
(42%)
our
initial
evaluation
diagnosis.
No
correlation
found
lymphocyte
subgroups
(p
>
0.05).
However,
a
positive
linear
CD8
+
T
cell
count
percentage
(r
=
0.192,
p
<
0.001;
r
0.118,
0.001,
respectively)
negative
ratio
(r=-0.092,
0.007)
ART.
did
not
show
any
significant
months
after
starting
NHTG
while
it
decreased
statistically
significantly
HTG
group
0.001).
Conclusion
The
decrease
control
immune
activation
promising
as
parameter.
Therefore,
data
from
new
prospective
needed
analyze
conditions
such
CVD
metabolic
syndrome
that
will
occur
longer
term
Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown
Published: March 31, 2025
Language: Английский