Colchicine: Repositioning an “ancient” medicine in the 21st century DOI Creative Commons
Е. Л. Насонов, О. М. Драпкина

Rheumatology Science and Practice, Journal Year: 2024, Volume and Issue: 62(5), P. 445 - 464

Published: Oct. 31, 2024

The main indications for colchicine treatment until recently were gout, pericarditis, familial Mediterranean fever and some other auto-inflammatory diseases. expansion of (repositioning) the use in direction prevention cardiovascular complications should be considered as one major events medicine XXI century. Deciphering role inflammation most important mechanism development atherosclerosis has created prerequisites concept anti-inflammatory therapy atherosclerosis, which low-dose can take an place, complementing effects aspirin, statins antihypertensive therapy. analysis materials from randomized placebo-controlled studies indicates a decrease frequency patients with coronary heart disease (by 31%) who have suffered myocardial infarction 23%), well 33%), stroke, need revascularization mortality. low dose (0.5 mg/day) is approved by U.S. Food Drug Administration disease. It assumed that future will place pathology associated atherosclerotic vascular

Language: Английский

Colchicine: A Dual Therapeutic Target for Trichinellosis DOI Creative Commons
Enas Abdelhamed,

A A Taha,

Shereen M. Abdel Ghany

et al.

Acta Parasitologica, Journal Year: 2025, Volume and Issue: 70(1)

Published: Jan. 24, 2025

Abstract Purpose Trichinellosis affects around 11 million people globally. Treatments for this medical condition are limited by adverse effects and resistance, emphasising the importance of effective safe therapies. Consequentially, we sought to study colchicine’s synergistic with atorvastatin or acetazolamide in treatment Trichinella spiralis ( T. spiralis) -infected mice. Methods Seventy mice were evenly divided into two groups (a b) 35 each. During intestinal phase, group (a) began therapy on second day post-infection (dpi) lasted four days. Group (b) had weeks during muscle beginning 12th dpi. While other five infected received atorvastatin, colchicine, acetazolamide, a combination none, one no at all as negative control. The efficacy was assessed parasite count, histopathology scanning electron microscopy. Results Our data revealed that lowered adult worm larvae counts animals. Moreover, it restored normal muscular architecture, reduced edema, alleviated inflammation, demonstrated inflammatory infiltrate. Scanning microscopic examination adults verified our findings. Conclusion Adjuvant colchicine an antifibrotic can help treat trichinellosis reducing production fibrous tissue. This might enhance results enabling admission larvicidal medications and, result, number muscle, which together form basis pathology be debilitating patient.

Language: Английский

Citations

0
The Role of Cardiac Magnetic Resonance in mRNA COVID-19 Vaccine-Related Myopericarditis: An Evolutive Case Series DOI Creative Commons
Gisela Feltes, Violeta Sánchez, Esther Pérez David

et al.

Journal of Cardiovascular Development and Disease, Journal Year: 2024, Volume and Issue: 11(9), P. 259 - 259

Published: Aug. 25, 2024

Numerous cases of myocarditis related to mRNA vaccines for COVID-19 have recently been described, usually in young men. Long-term evolutive cardiac magnetic resonance imaging (CMR) data are lacking. We describe four consecutive vaccine-induced myocarditis. The pathological findings confirmed the diagnosis acute phase, showing edema, as well pericardial enhancement, with light effusion and late gadolinium enhancement (LGE), predominantly inferolateral wall. These highlight unique value patients suspected induced by RNAm a tool confirm diagnosis, avoiding other invasive techniques, long-term follow-up patients. Our iterative CMR demonstrated frequent LGE persistence.

Language: Английский

Citations

1
Repurposing existing drugs for the treatment ofCOVID-19/SARS-CoV-2: A review of pharmacological effects and mechanism of action DOI Creative Commons
Yutong Liang,

Xiaoxiao Quan,

Ruolan Gu

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(16), P. e35988 - e35988

Published: Aug. 1, 2024

Language: Английский

Citations

0
A Comprehensive Review of Colchicine: An Ancient Drug with Many Therapeutic Potentials DOI
Kholoud Elshiwy, Ghada Essam El-Din Amin,

Mohamed Nazmy Farres

et al.

International Journal of Pharmaceutical and Phytopharmacological Research, Journal Year: 2024, Volume and Issue: 14(4), P. 17 - 22

Published: Jan. 1, 2024

Language: Английский

Citations

0
Colchicine: Repositioning an “ancient” medicine in the 21st century DOI Creative Commons
Е. Л. Насонов, О. М. Драпкина

Rheumatology Science and Practice, Journal Year: 2024, Volume and Issue: 62(5), P. 445 - 464

Published: Oct. 31, 2024

The main indications for colchicine treatment until recently were gout, pericarditis, familial Mediterranean fever and some other auto-inflammatory diseases. expansion of (repositioning) the use in direction prevention cardiovascular complications should be considered as one major events medicine XXI century. Deciphering role inflammation most important mechanism development atherosclerosis has created prerequisites concept anti-inflammatory therapy atherosclerosis, which low-dose can take an place, complementing effects aspirin, statins antihypertensive therapy. analysis materials from randomized placebo-controlled studies indicates a decrease frequency patients with coronary heart disease (by 31%) who have suffered myocardial infarction 23%), well 33%), stroke, need revascularization mortality. low dose (0.5 mg/day) is approved by U.S. Food Drug Administration disease. It assumed that future will place pathology associated atherosclerotic vascular

Language: Английский

Citations

0