Characterization of rectus femoris lesions in knee osteoarthritis at different stages and the effect of ultrasound-guided acupotomy DOI Creative Commons
Wenying Yu, Jing Liu,

Ze-Hao Lin

et al.

Frontiers in Physiology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 23, 2025

Introduction Chronic injury to the rectus femoris muscle induces and exacerbates progression of knee osteoarthritis (KOA). However, lesion characteristics in KOA at different stages have not been fully characterized. The aim this study was analyze pattern investigate mechanism by which ultrasound-guided acupotomy operations can prevent control KOA. Methods Early, middle, late-stage rabbit models were constructed using modified Videman method. Ultrasonography used record elastic modulus cross-sectional area muscle, morphology observe ultramicroscopic changes assess degree fibrosis. Additionally, performed on model KOA, alterations key molecular markers fibrosis determined Western Blot qPCR methods. Results As disease progressed, rabbits gradually increased, decreased, increased. In contrast, improved after intervention. Conclusion These findings highlight gradual increase elasticity, decrease area, increased as progressed. Ultrasoundguided shown a protective effect cartilage delay ameliorating pathological muscle. may involve reducing chronic protecting joint homeostasis attenuating

Language: Английский

Characterization of rectus femoris lesions in knee osteoarthritis at different stages and the effect of ultrasound-guided acupotomy DOI Creative Commons
Wenying Yu, Jing Liu,

Ze-Hao Lin

et al.

Frontiers in Physiology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 23, 2025

Introduction Chronic injury to the rectus femoris muscle induces and exacerbates progression of knee osteoarthritis (KOA). However, lesion characteristics in KOA at different stages have not been fully characterized. The aim this study was analyze pattern investigate mechanism by which ultrasound-guided acupotomy operations can prevent control KOA. Methods Early, middle, late-stage rabbit models were constructed using modified Videman method. Ultrasonography used record elastic modulus cross-sectional area muscle, morphology observe ultramicroscopic changes assess degree fibrosis. Additionally, performed on model KOA, alterations key molecular markers fibrosis determined Western Blot qPCR methods. Results As disease progressed, rabbits gradually increased, decreased, increased. In contrast, improved after intervention. Conclusion These findings highlight gradual increase elasticity, decrease area, increased as progressed. Ultrasoundguided shown a protective effect cartilage delay ameliorating pathological muscle. may involve reducing chronic protecting joint homeostasis attenuating

Language: Английский

Citations

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