Risk factors and related miRNA phenotypes of chronic pain after thoracoscopic surgery in lung adenocarcinoma patients

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(3), P. e0297742 - e0297742

Published: March 14, 2024

Chronic postsurgical pain may have a substantial impact on patient's quality of life, and has highly heterogenous presentation amongst sufferers. We aimed to explore the risk factors relating chronic related miRNA phenotypes in patients with lung adenocarcinoma after video-assisted thoracoscopic lobectomy identify potential biomarkers. Our prospective study involved total 289 early invasive undergoing lobotomy follow-up period 3 months surgery. Blood was collected day before surgery for detection patient information including operation duration, duration continuous drainage chest, leukocyte count operation, postoperative scores were recorded. Using clinical biochemical each patient, screened. found that associated higher body mass index; greater preoperative history pain; longer tube retention duration; numerical rating scale one, two, three days surgery; changes expression, namely lower expression 146a-3p 550a-3p 3613-3p peripheral blood (p < 0.05). Of these factors, index, pain, average score 550a-3P independent development pain. Identification individual markers aid selection appropriate preventive control measures.

Language: Английский

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The Impact of Different Regional Anesthesia Techniques on the Incidence of Chronic Post-surgical Pain in Patients Undergoing Video-Assisted Thoracoscopic Surgery: A Network Meta-analysis

Pain and Therapy, Journal Year: 2024, Volume and Issue: 13(6), P. 1335 - 1350

Published: Sept. 6, 2024

Language: Английский

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Comparison between thoracic epidural analgesia VS patient controlled analgesia on chronic postoperative pain after video-assisted thoracoscopic surgery: A prospective randomized controlled study

Journal of Clinical Anesthesia, Journal Year: 2024, Volume and Issue: 100, P. 111685 - 111685

Published: Nov. 27, 2024

Language: Английский

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Nomogram prediction of chronic postsurgical pain in patients with lung adenocarcinoma after video-assisted thoracoscopic surgery: A prospective study

Frontiers in Surgery, Journal Year: 2022, Volume and Issue: 9

Published: Nov. 9, 2022

Chronic postsurgery pain (CPSP) refers to persistent or repeated around the incision after surgery. Different from acute postoperative pain, persistence of CPSP seriously affects quality life patients. has a considerable global impact due large surgical volumes. Although development video-assisted thoracoscopy (VATS) reduced risk CPSP, it still patients’ life. Clinical recognition at an early stage is limited; therefore, we aimed develop and validate nomogram identify significant predictive factors associated with VATS in patients lung adenocarcinoma. We screened 137 invasive adenocarcinoma among 312 undergoing VATS. In this prospective study, were divided into ( n = 52) non-CPSP 85) groups according occurrence CPSP. Relevant information was collected 1 day before surgery 1–3 days surgery, followed up by telephone 3 months Data on clinical characteristics peripheral blood leukocyte miRNAs used establish for predicting using least absolute shrinkage selection operator (LASSO) regression methods. The area under curve (AUC) determine ability nomograms. model subjected correction decision analyses. Four variables—body mass index (BMI), history chronic miR 550a-3p, visual analog scale (VAS) score 2 (VAS2d)—were selected LASSO build nomogram. demonstrated adequate calibration discrimination prediction model, AUC 0.767 (95% confidence interval: 0.679–0.856). plot showed best fit between predictions practical observations, suggesting that use proposed predict beneficial. A consisting BMI, VAS2d predicted

Language: Английский

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Transitional Pain Medicine; New Era, New Opportunities, and New Journey

Anesthesiology Clinics, Journal Year: 2023, Volume and Issue: 41(2), P. 383 - 394

Published: April 8, 2023

Language: Английский

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