Dynamic In Vitro PK/PD Infection Models for the Development and Optimisation of Antimicrobial Regimens: A Narrative Review DOI Creative Commons
Yalew Molla, Jason Roberts, Fekade B. Sime

et al.

Antibiotics, Journal Year: 2024, Volume and Issue: 13(12), P. 1201 - 1201

Published: Dec. 10, 2024

The antimicrobial concentration–time profile in humans affects activity, and as such, it is critical for preclinical infection models to simulate human-like dynamic profiles maximal translatability. This review discusses the setup, principle, application of various vitro PK/PD commonly used development optimisation treatment regimens. It covers models, including one-compartment model, hollow fibre biofilm bladder aspergillus model. summarises mathematical methods simulation pharmacokinetic single or multiple antimicrobials when using serial parallel configurations systems. Dynamic offer reliable pharmacokinetic/pharmacodynamic data help define initial dosing regimens new that can be developed further clinical trials. They also existing antimicrobials, especially presence emerging resistance. In conclusion, replicate interactions occur between microorganisms exposures human body generate highly predictive efficacy. are particularly useful strategies against antimicrobial-resistant pathogens.

Language: Английский

Dynamic In Vitro PK/PD Infection Models for the Development and Optimisation of Antimicrobial Regimens: A Narrative Review DOI Creative Commons
Yalew Molla, Jason Roberts, Fekade B. Sime

et al.

Antibiotics, Journal Year: 2024, Volume and Issue: 13(12), P. 1201 - 1201

Published: Dec. 10, 2024

The antimicrobial concentration–time profile in humans affects activity, and as such, it is critical for preclinical infection models to simulate human-like dynamic profiles maximal translatability. This review discusses the setup, principle, application of various vitro PK/PD commonly used development optimisation treatment regimens. It covers models, including one-compartment model, hollow fibre biofilm bladder aspergillus model. summarises mathematical methods simulation pharmacokinetic single or multiple antimicrobials when using serial parallel configurations systems. Dynamic offer reliable pharmacokinetic/pharmacodynamic data help define initial dosing regimens new that can be developed further clinical trials. They also existing antimicrobials, especially presence emerging resistance. In conclusion, replicate interactions occur between microorganisms exposures human body generate highly predictive efficacy. are particularly useful strategies against antimicrobial-resistant pathogens.

Language: Английский

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