Weight Management Strategies to Reduce Metabolic Morbidity in Women With Polycystic Ovary Syndrome DOI Creative Commons
Michail Diakosavvas, Oyinlola Oyebode, Priya Bhide

et al.

Current Obesity Reports, Journal Year: 2025, Volume and Issue: 14(1)

Published: March 6, 2025

Polycystic Ovary Syndrome (PCOS) affects 10-15% of women reproductive age and is associated with a heightened risk metabolic morbidity, exacerbated by insulin resistance obesity. Current weight management strategies have limited effectiveness in reducing morbidity this subgroup. This review examines the potential Intensive Weight Management Programmes (IWMPs) Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) to reduce risks PCOS, drawing from studies both PCOS-specific related populations. IWMPs, including total diet replacement, achieve substantial sustained loss (5-15% over 1-5 years) individuals obesity type 2 diabetes, alongside improvements markers like blood pressure glycemic control. GLP-1 RAs, particularly semaglutide, similarly deliver significant (10-15% 1-2 benefits. While there data specifically targeting emerging suggest RAs can improve weight, sensitivity, menstrual regularity group. However, evidence for interventions PCOS remains insufficient. Women face unique challenges, resistance, compounded IWMPs are promising interventions, their populations Addressing research gap through targeted trials essential outcomes affected disorders.

Language: Английский

Effects of high-protein diets on the cardiometabolic factors and reproductive hormones of women with polycystic ovary syndrome: a systematic review and meta-analysis DOI Creative Commons
Fang Wang,

Pan Dou,

Wei Wei

et al.

Nutrition and Diabetes, Journal Year: 2024, Volume and Issue: 14(1)

Published: Feb. 29, 2024

The optimal dietary regimen for polycystic ovary syndrome (PCOS) has not been identified. High-protein diets (HPDs) are effective weight control in individuals with metabolic abnormalities, but no systematic meta-analyses have yet summarised the effects of HPDs on PCOS. Seven electronic databases were searched from inception to 30 April 2023, and studies comparing other anthropometrics, factors, hormonal profiles PCOS Data pooled using random-effects models expressed as weighted mean differences 95% confidence intervals. risk bias was assessed by Cochrane Collaboration tool. Eight trials involving 300 women included. Compared isocaloric balanced (BDs), significantly reduced fasting insulin (-2.69 μIU/mL, CI [-3.81, -1.57], P < 0.0001, I

Language: Английский

Citations

5
BMI and Polycystic Ovary Syndrome: Demographic Trends in Weight and Health DOI Open Access
Ipsita Mohapatra, Subha Ranjan Samantaray

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: March 3, 2024

Introduction Polycystic ovary syndrome (PCOS) is a common endocrine disorder that affects women in adolescence and reproductive age. The distribution of PCOS across different body mass index (BMI) categories can vary, research has shown associations between weight status. This study tries to evaluate the relation BMI attending clinic tertiary hospital eastern India. Methodology hospital-based cross-sectional was carried out gynecology outpatient department care center. population included all age group 15 45 years diagnosed as having using Rotterdam definition. various physical, clinical, biochemical parameters were measured compared among obese lean patients. Results discussion A total 143 study. mean 26.8 years. Among these, underweight normal patients categorized patients, 35 number (24.5%), overweight 108 (75.5%). All physical parameter measures like (mean = 28.05, SD 5.722), height 153.384, 6.679), 68.182, 11.501), waist circumference 95.135, 10.291), hip 101.47, 9.320), waist-to-hip ratio 0.940, 0.0831), neck 34.85, 2.445) significantly higher group. Menstrual irregularity more (p 0.02). There significant difference < 0.05) when fasting insulin, glucose, homeostatic model assessment insulin resistance (HOMA-IR) compared. strong link obesity, resistance, PCOS. Obesity exacerbate feature PCOS, leading increased levels androgens. Conclusion demographic essential for tailoring interventions treatments.

Language: Английский

Citations

5
Food Cravings and Obesity in Women with Polycystic Ovary Syndrome: Pathophysiological and Therapeutic Considerations DOI Open Access
Katerina Stefanaki, Dimitrios S. Karagiannakis, Μelpomeni Peppa

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(7), P. 1049 - 1049

Published: April 3, 2024

Polycystic ovary syndrome (PCOS), the most common endocrine disorder in women of reproductive age, constitutes a metabolic frequently associated with obesity and insulin resistance (IR). Furthermore, PCOS often suffer from excessive anxiety depression, elicited by low self-esteem due to obesity, acne, hirsutism. These mood disorders are commonly food cravings binge eating. Hypothalamic signaling regulates appetite satiety, deteriorating consumption. However, hypothalamic function is incapable compensating for surplus PCOS, leading aggravation vicious circle. Hyperandrogenism, IR, reduced secretion cholecystokinin postprandially, leptin defined receptors' knockout hypothalamus have been implicated pathogenesis dysfunction dysregulation. Diet modifications, exercise, psychological medical interventions applied alleviate disorders, interrupting Cognitive-behavioral intervention seems be mainstay treatment, while role agents, such as GLP-1 analogs naltrexone/bupropion, has emerged.

Language: Английский

Citations

4
Enhancing angiogenesis and inhibiting apoptosis: evaluating the therapeutic efficacy of bone marrow mesenchymal stem cell-derived exosomes in a DHEA-induced PCOS mouse model DOI Creative Commons
Xiaojing Teng, Zhiyi Wang, Xiaolei Wang

et al.

Journal of Ovarian Research, Journal Year: 2024, Volume and Issue: 17(1)

Published: June 5, 2024

Polycystic Ovary Syndrome (PCOS) is a widespread endocrine disorder among women, characterized by symptoms like ovarian cysts, hormonal imbalance, and metabolic issues. This research evaluates the therapeutic potential of Bone Marrow Mesenchymal Stem Cell-derived exosomes (BMSC-Exo) in treating PCOS within mouse model.

Language: Английский

Citations

4
Effects of dietary approaches to prevent hypertension and enhance cardiovascular health DOI Creative Commons
Arumugam Vignesh,

Thomas Cheeran Amal,

A. Shanmugam

et al.

Discover Food, Journal Year: 2025, Volume and Issue: 5(1)

Published: Jan. 11, 2025

Hypertension (HT) significantly impacts cardiovascular health (CVH) by exerting chronic stress on arteries and the heart, leading to severe complications. This review explores intricate relationship between dietary choices high blood pressure (BP). Dietary are crucial in both development management of BP. Excessive sodium intake is a well-documented risk factor for HT, strategies reduce salt consumption can mitigate its adverse effects. Processed packaged foods also pose risks due hidden other unhealthy ingredients, making healthier alternatives essential. Potassium plays vital role managing BP, with potassium-rich supporting balanced diet. Saturated trans fats contribute elevated fat recommended. sugar negatively affects sugars popular requiring practical reduction. Alcohol caffeine influence moderate advised avoid potential risks. The Mediterranean diet offers holistic, evidence-based approach enhancing CVH, advice meal plans flavourful health-promoting regimen.

Language: Английский

Citations

0
Efeito de medidas não farmacológicas no controle de sinais e sintomas em pacientes com síndrome dos ovários policísticos DOI Creative Commons
A. Oliveira,

Carolyne Stephany de Oliveira Gouvea,

Clarisse Bezri Hermont

et al.

Contribuciones a las Ciencias Sociales, Journal Year: 2025, Volume and Issue: 18(1), P. e14650 - e14650

Published: Jan. 16, 2025

Introdução: A síndrome dos ovários policísticos (SOP) é uma condição endócrina prevalente, afetando cerca de 10% das mulheres em idade reprodutiva, segundo a Sociedade Brasileira Endocrinologia e Metabologia (SBEM). Embora o tratamento farmacológico seja amplamente utilizado, existe lacuna no conhecimento sobre as contribuições intervenções não farmacológicas na qualidade vida pacientes. Objetivo: Avaliar influência manejo clínico da SOP. Metodologia: Revisão integrativa feita partir buscas literatura nas bases dados “PubMed” “Scielo”. 12 trabalhos foram incluídos avaliação criteriosa relacionada ao tema proposto. Resultados: As farmacológicas, como suplementação coenzima Q10 vitamina E, aliadas mudanças estilo vida, demonstraram melhorar parâmetros metabólicos, hormonais emocionais com Discussão: Intervenções dietas específicas exercícios aeróbicos, mostraram benefícios significativos gestão SOP, incluindo melhora perfil lipídico, redução insulina marcadores inflamatórios, reequilíbrio hormonal. Exercícios HIIT também contribuíram para melhorias saúde mental vida. abordagem desses aspectos demonstrou impactos positivos tanto físicos quanto psicológicos, destacando importância estratégias personalizadas condição. Conclusão: SOP demanda um integrado, envolvendo, além terapia farmacêutica, alimentação baixo índice glicêmico, prática regular alimentar. Além disso, apoio psicológico fundamental lidar os síndrome. combinação dessas significativamente pacientes Entretanto, ainda necessário mais pesquisas validar tais resultados..

Citations

0
Comparing the Effect of Heat Therapy and Mitochondrial-Targeted Antioxidants in Polycystic Ovarian Syndrome Phenotype Induced by Junk Food Consumption DOI
Shaimaa Nasr Amin, Iman Aolymat, Sara Adel Hosny

et al.

Reproductive Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 17, 2025

Language: Английский

Citations

0
Anxiety and Depression in Polycystic Ovary Syndrome: An Analysis Using the Hospital Anxiety and Depression Scale (HADS) in Women from a Low-Income Country DOI

Daiane Oliveira Simão,

André Soares Santos, V Vieira

et al.

Experimental and Clinical Endocrinology & Diabetes, Journal Year: 2025, Volume and Issue: 133(02), P. 105 - 107

Published: Jan. 22, 2025

Polycystic ovary syndrome (PCOS) is a complex disease and the most common endocrine condition that affects women of reproductive age. Its prevalence ranges from 5% to 20%, characterized by hyperandrogenism, menstrual irregularities, presence polycystic dysfunctional ovaries [1] [2] [3] [4] [5] [6].

Language: Английский

Citations

0
Changing trends in the global burden of polycystic ovarian syndrome-related infertility over the past 30 years: retrospective data analysis of the global burden of disease study 2019 DOI Creative Commons

Ming Huo,

Yixiang Wang,

Xianbin Yuan

et al.

BMC Women s Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 23, 2025

Language: Английский

Citations

0
Impact of #PCOSweightloss: A global X hashtag analysis study of weight loss narratives in the PCOS community DOI Creative Commons

Munaza Afaq,

Kumar Vashisht,

Areen Al-Dhoon

et al.

Digital Health, Journal Year: 2025, Volume and Issue: 11

Published: Jan. 1, 2025

Social media plays a significant role in fostering communities around health and wellness. The hashtag #PCOSweightloss has become pivotal forum on the platform X, where individuals exchange experiences, share information, motivate each other concerning weight loss strategies connected with Polycystic Ovary Syndrome (PCOS). This study aims to analyze trends of X gain insights into social metrics, including overall reach, key themes, potential influence management practices PCOS. Fedica research analytics tool (https://fedica.com) was utilized automatically evaluate quantitatively posts containing from July 1st, 2017 2023. During defined period, 1570 users shared 12,200 gathering 2,967,001 views. highest number originated United States (38.6%), followed by India (30.6%) Kingdom (10.6%). Top co-occurring hashtags associated included #PCOS, #healthyfood, #pcosmood #diabetes. Physicians were contributors discourse, contributing 30% ten most engaging 20% top influencers. Sentiment analysis revealed predominant neutral sentiment (98%), while 1% positive negative sentiments. Our affirms substantial presence PCOS discourse X. involvement physicians is particularly noteworthy, as it emphasizes importance expert-guided discussions online discourse. On background geographical variances challenge wider audience due limited follower counts many participants, there clear opportunity for further community engagement outreach. prevailing tone showcases engaged primarily an informational exchange, setting stage more profound novel strategies.

Language: Английский

Citations

0