Chili pepper: A delve into its nutritional values and roles in food-based therapy

Food Chemistry Advances, Journal Year: 2025, Volume and Issue: 6, P. 100928 - 100928

Published: Feb. 16, 2025

Language: Английский

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Linear pyranocoumarins are potential dazzling dancers between nature, chemistry, and clinical application

Phytomedicine Plus, Journal Year: 2025, Volume and Issue: unknown, P. 100785 - 100785

Published: March 1, 2025

Language: Английский

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Capsicum in Clinical Biochemistry: Insights into its Role in Health and Disease

Indian Journal of Clinical Biochemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 25, 2025

Language: Английский

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Soluble Receptor of Advanced Glycation End Products and Cardiometabolic Markers in Children

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: April 3, 2025

Background The soluble receptor for advanced glycation end products (sRAGE) is a proposed obesity biomarker, but its role in childhood has not been fully elucidated. This study aimed to evaluate the association between sRAGE levels and cardiometabolic factors children according body mass index (BMI). Introduction cross-sectional included 124 aged 6-9 years, categorized as normal weight (n=72) overweight or with (n=52). Anthropometric clinical measurements weight, height, BMI, waist circumference (WC), neck circumference, systolic diastolic blood pressure (SBP DBP). Fasting samples were collected measure glucose, lipid profile, uric acid (UA), using standardized methods. We also calculated triglyceride-glucose (TyG), visceral adiposity (VAI), triglyceride-to-HDL-C (TG:HDL-C) ratio. Results Children who obese exhibited lower compared normal-weight group (p= 0.02) higher WC, NC, UA, HDL-C, TG, SBP, DBP, TyG, TG:HDL-C ratio, VAI than (p<0.01). No differences creatinine, cholesterol found. Finally, showed correlations BMI (r=-0.358, p=0.03), WC (r=-0.242, p=0.00), HDL-cholesterol (r=0.207, p=0.01). Conclusions presented risk markers, including TG: HDL-C TyG index, score, group.

Language: Английский

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The Advanced Glycation End-Products (AGE)–Receptor for AGE System (RAGE): An Inflammatory Pathway Linking Obesity and Cardiovascular Diseases

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3707 - 3707

Published: April 14, 2025

The AGE (advanced glycation end-products)–RAGE (receptor for AGE) system is a pro-inflammatory pathway that contributes to the pathogenesis of obesity and obesity-related cardiovascular disorders (CVD). Circulating soluble form RAGE (sRAGE) has been suggested as potential biomarker CVD related obesity. In this study, we aim (1) summarize current knowledge about role in onset progression CVD, (2) discuss AGE–RAGE promoting linking (3) highlight available strategies reducing activation associated beneficial effects.

Language: Английский

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Relationship between sRAGE and obesity in individuals with type 1 diabetes during a median follow-up of 6.3 years

Diabetologia, Journal Year: 2025, Volume and Issue: unknown

Published: April 29, 2025

Abstract Aims/hypothesis Soluble receptor for advanced glycation end products (sRAGE) has been inversely linked to obesity, which is defined by excess of total body fat. However, fat accumulation also relevant health. In this study, we investigated associations between sRAGE and obesity in individuals with type 1 diabetes over 6.3 years follow-up. Methods The study included 3886 adults from the FinnDiane study. Serum concentrations were determined ELISA. Central was on basis waist/height ratio (WHtR), general BMI. Kruskal–Wallis test used assess differences baseline BMI, WHtR concentrations, comparing groups stratified albuminuria status. Changes BMI calculated time Wilcoxon rank comparisons. Linear regression, adjusted sex, age, HbA 1c , assessing association measures at baseline, changes time. Results Over a median follow-up years, changed Δ 0.76 kg/m 2 (IQR −0.39 2.07; p <0.001) 0.019 −0.007 0.05; <0.001). change observed 67% individuals, 68% them. Baseline associated ( r =0.07, β −0.174; =0.16, −0.179; overall cohort. These relationships remained consistent across subgroups status, including no, moderate severe (all not or Conclusions/interpretation both central as represented WHtR, independent kidney disease, suggesting biomarker obesity. year Future research longer merited understand how correlates accumulation. Graphical

Language: Английский

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Mechanistic Insights into the Anti-Obesity Actions of Coumarins: Therapeutic Potential and Future Directions

Obesity Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 100620 - 100620

Published: May 1, 2025

Language: Английский

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