Role of long noncoding RNAs in diabetes-associated peripheral arterial disease DOI Creative Commons
Alonso Tapia, Xuejing Liu, Naseeb Kaur Malhi

et al.

Cardiovascular Diabetology, Journal Year: 2024, Volume and Issue: 23(1)

Published: July 24, 2024

Abstract Diabetes mellitus (DM) is a metabolic disease that heightens the risks of many vascular complications, including peripheral arterial (PAD). Various types cells, but not limited to endothelial cells (ECs), smooth muscle (VSMCs), and macrophages (MΦs), play crucial roles in pathogenesis DM-PAD. Long non-coding RNAs (lncRNAs) are epigenetic regulators important cellular function, their dysregulation DM can contribute PAD. This review focuses on developing field lncRNAs emerging linking We studies investigating role processes contributing DM-PAD, those ECs, VSMCs, MΦ. By examining intricate molecular landscape governed by these relevant cell types, we hope shed light EC dysfunction, inflammatory responses, remodeling Additionally, provide an overview research approach methodologies, from identifying disease-relevant characterizing functions context also discuss potential leveraging diagnosis therapeutics for Collectively, this provides summary lncRNA-regulated DM-PAD highlights translational lncRNA biology tackle increasingly prevalent complex disease. Graphical

Language: Английский

Review on the role of nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome pathway in diabetes: mechanistic insights and therapeutic implications DOI
Abhishek Satheesan, Janardanan Kumar,

K.V. Leela

et al.

Inflammopharmacology, Journal Year: 2024, Volume and Issue: 32(5), P. 2753 - 2779

Published: Aug. 19, 2024

Language: Английский

Citations

6
A compendium of noncoding RNAs as biomarkers in Type 2 Diabetes Mellitus DOI Creative Commons

Akella Sita Manjusha,

Angel Mendonca,

Thanikes Manikandan

et al.

Journal of Pharmaceutical and Biomedical Analysis Open, Journal Year: 2025, Volume and Issue: unknown, P. 100057 - 100057

Published: Jan. 1, 2025

Language: Английский

Citations

0
Crosstalk between microRNA and inflammation; critical regulator of diabetes DOI

Amr Ali Mohamed Abdelgawwad El-Sehrawy,

Mohammed H. Mohammed,

Omar Dheyauldeen Salahdin

et al.

Experimental Cell Research, Journal Year: 2025, Volume and Issue: 447(1), P. 114507 - 114507

Published: March 7, 2025

Language: Английский

Citations

0
Role of long noncoding RNAs in diabetes-associated peripheral arterial disease DOI Creative Commons
Alonso Tapia, Xuejing Liu, Naseeb Kaur Malhi

et al.

Cardiovascular Diabetology, Journal Year: 2024, Volume and Issue: 23(1)

Published: July 24, 2024

Abstract Diabetes mellitus (DM) is a metabolic disease that heightens the risks of many vascular complications, including peripheral arterial (PAD). Various types cells, but not limited to endothelial cells (ECs), smooth muscle (VSMCs), and macrophages (MΦs), play crucial roles in pathogenesis DM-PAD. Long non-coding RNAs (lncRNAs) are epigenetic regulators important cellular function, their dysregulation DM can contribute PAD. This review focuses on developing field lncRNAs emerging linking We studies investigating role processes contributing DM-PAD, those ECs, VSMCs, MΦ. By examining intricate molecular landscape governed by these relevant cell types, we hope shed light EC dysfunction, inflammatory responses, remodeling Additionally, provide an overview research approach methodologies, from identifying disease-relevant characterizing functions context also discuss potential leveraging diagnosis therapeutics for Collectively, this provides summary lncRNA-regulated DM-PAD highlights translational lncRNA biology tackle increasingly prevalent complex disease. Graphical

Language: Английский

Citations

1