Relationship between dietary flavan-3-ols intake and mortality in metabolic syndrome population; a large cohort study DOI Creative Commons
Wanjia Zhang, Qian Zhou, Weiqing Yang

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: April 10, 2025

Metabolic syndrome (MetS) is a global health concern linked to increased mortality. Diets rich in plant-derived compounds, such as polyphenols, have shown potential benefits for MetS. Among these, flavan-3-ols, class of commonly occurring polyphenolic are known their antioxidant and anti-inflammatory properties. Therefore, we hypothesize that flavan-3-ols intake negatively associated with mortality risk MetS population. This study analyzed NHANES data (2007-2008, 2009-2010, 2017-2018). Flavan-3-ol monomer were obtained from the USDA Flavonoid FNDDS databases. Associations assessed using Cox regression, survival differences compared Kaplan-Meier curves, non-linear trends examined restricted cubic splines. Subgroup analyses conducted explore effect modifications. Over median follow-up period 114 months, 1,856 participants survived, while 329 deaths recorded. In Model 3, highest tertile (T3) flavan-3-ol exhibited 33% lower all-cause those lowest (T1) (HR = 0.67, 95%CI: 0.49-0.92). For monomers, hazard ratios ranged 0.55 higher levels epigallocatechin 0.71 gallocatechin. curves indicated significant status across dietary groups. However, no association was found between cardiovascular risk. Additionally, spline (RCS) analysis did not reveal any relationship, interaction effects observed subgroup analysis. Higher

Language: Английский

Vitamin D deficiency in overweight patients: current strategies and practical aspects DOI
Т. Л. Каронова, В. В. Салухов, Larisa Dzeranova

et al.

Problems of Endocrinology, Journal Year: 2025, Volume and Issue: 71(1), P. 92 - 98

Published: Jan. 27, 2025

On September 27, 2024, a discussion-based working meeting on the issue of vitamin D deficiency in patients with overweight and obesity was held Vladikavkaz.The aimed to evaluate relationship between deficiency, overweight, associated comorbidities, as well explore modern strategies practical approaches for managing such endocrinology practice. The resolution developed by its participants, comprising leading endocrinologists.

Language: Английский

Citations

0
Relationship between dietary flavan-3-ols intake and mortality in metabolic syndrome population; a large cohort study DOI Creative Commons
Wanjia Zhang, Qian Zhou, Weiqing Yang

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: April 10, 2025

Metabolic syndrome (MetS) is a global health concern linked to increased mortality. Diets rich in plant-derived compounds, such as polyphenols, have shown potential benefits for MetS. Among these, flavan-3-ols, class of commonly occurring polyphenolic are known their antioxidant and anti-inflammatory properties. Therefore, we hypothesize that flavan-3-ols intake negatively associated with mortality risk MetS population. This study analyzed NHANES data (2007-2008, 2009-2010, 2017-2018). Flavan-3-ol monomer were obtained from the USDA Flavonoid FNDDS databases. Associations assessed using Cox regression, survival differences compared Kaplan-Meier curves, non-linear trends examined restricted cubic splines. Subgroup analyses conducted explore effect modifications. Over median follow-up period 114 months, 1,856 participants survived, while 329 deaths recorded. In Model 3, highest tertile (T3) flavan-3-ol exhibited 33% lower all-cause those lowest (T1) (HR = 0.67, 95%CI: 0.49-0.92). For monomers, hazard ratios ranged 0.55 higher levels epigallocatechin 0.71 gallocatechin. curves indicated significant status across dietary groups. However, no association was found between cardiovascular risk. Additionally, spline (RCS) analysis did not reveal any relationship, interaction effects observed subgroup analysis. Higher

Language: Английский

Citations

0