Investigating the Effect of Capsaicin Oral Solution in the Treatment of Burning Mouth in Patients: A Randomized Clinical Trial
Research Square (Research Square),
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 31, 2025
Abstract
Background
Burning
mouth
syndrome
is
one
of
the
most
prevalent
complications
oral
cavity
with
unclear
etiology,
which
has
led
to
offering
inconclusive
treatments.
Due
limited
studies
on
effects
solution
form
capsaicin
BMS,
this
study
was
conducted
aim
investigating
effect
in
treatment
burning
patients.
Methods
In
double-blind
clinical
trial
study,
22
eligible
female
patients
suffering
from
were
randomly
divided
into
2
case
and
control
groups.
group,
subjects
dissolved
10
drops
1
tablespoon
water
swished
times
a
day
for
minute
their
30
days.
The
same
way
consumption
prescribed
group
that
used
placebo
solution.
Vitamin
B
zinc
supplements
also
given
both
groups,
amount
assessed
by
visual
analog
scale,
non-stimulating
saliva
determined
Schirmer's
test,
xerostomia
quality
life
recorded
standard
questionnaires
days
0
intervention.
Results
findings
research
exhibited
variables
mouth,
xerostomia,
saliva,
show
significant
difference
before
after
intervention
(p
value
<
0.05).
However,
there
no
prominent
between
groups
at
regarding
4
mentioned
>
Conclusions
It
concluded
use
twice
days,
along
vitamin
supplements,
cannot
improve
sensation,
levels
compared
placebo.
Nonetheless,
it
observed
all
parameters
slightly
improved
Trial
registration
study’s
protocol
followed
Declaration
Helsinki
approved
ethics
committee
Islamic
Azad
University
Faculty
Dentistry,
Tehran,
Iran
(IR.IAU.DENTAL.REC.1400.155)
01/10/2022,
subscribed
Iranian
registry
trials
(IRCT20220117053748N1).
available
https//irct.behdasht.gov.ir/trial/61360.
Language: Английский
Cancer treatment-related xerostomia: basics, therapeutics, and future perspectives
European journal of medical research,
Journal Year:
2024,
Volume and Issue:
29(1)
Published: Nov. 30, 2024
Xerostomia,
generally
addressed
as
dry
mouth,
poses
significant
challenges
to
patients'
quality
of
life,
particularly
in
the
context
cancer
treatment.
Although
various
medications
and
interventions,
including
salivary
substitutes
stimulants,
muscarinic
agonists,
antineoplastic
detoxifying
agents,
anti-inflammatory
superoxide
dismutase
mimetics,
mesenchymal
stem
cells,
submandibular
gland
transfer,
intensity-modulated
radiation
therapy,
dose
fractionation,
transcutaneous
electrical
nerve
stimulation,
hyperbaric
oxygen
photobiomodulation,
acupuncture,
nutritional
have
been
proposed
for
this
condition,
no
approved
or
definite
treatments
are
currently
available.
Moreover,
evidence
supporting
efficacy
interventions
remains
limited
subject
controversy
terms
safety,
efficacy,
optimal
protocol.
This
review
provides
a
comprehensive
insight
into
treatment-related
xerostomia,
underlying
its
pathophysiology,
etiology,
clinical
manifestation,
therapeutic
options,
providing
guide
clinicians
adopt
patient-tailored
approach
xerostomia
offering
vision
on
current
ongoing
future
studies
field.
Language: Английский
Dental manifestations of antitumor therapy: literature review and practical recommendations
Russian Journal of Dentistry,
Journal Year:
2024,
Volume and Issue:
28(4), P. 399 - 411
Published: July 3, 2024
Anticancer
therapy
is
associated
with
a
wide
range
of
systemic
symptoms,
including
oral
pathologies,
such
as
dry
mouth,
mucositis,
masticatory
spasm,
osteoradionecrosis,
dental
caries,
opportunistic
infections,
dysphagia,
hypogeusia,
dysgeusia,
and
hyposalivation.
Dental
professionals
are
the
most
qualified
experts
in
diagnosis
treatment
well
their
prevention
control
cancer
patients
receiving
radiation
or
chemotherapy.
The
aim
review
was
to
assess
domestic
international
literature
on
primary
complications
anticancer
therapy.
also
aimed
highlight
importance
care
improving
quality
life
these
patients,
provide
practical
guidelines
for
managing
complications.
search
performed
using
electronic
databases
PubMed,
eLIBRARY.RU,
Google
Scholar.
yielded
55
sources,
which
were
included
review.
may
result
significant
hyposalivation,
changes
taste,
pain.
These
symptoms
can
affect
various
functions
cavity
oropharynx,
causing
mouth
difficulties
chewing
swallowing,
impairs
nutrition.
Moreover,
they
speech,
hygiene,
denture
treatment,
appearance,
all
be
detrimental
health,
social
emotional
wellbeing.
side
effects
reduce
compliance
therapy,
affecting
outcomes,
overall
costs.
When
examining
professional
must
consider
prescribed
potential
long-term
similar
those
bisphosphonates.
As
result,
patient
will
continue
receive
necessary
any
new
problems
identified
early.
Language: Английский
Transdermal pilocarpine on the skin over salivary glands to increase salivation: an in vivo study
Natsuko Ishida,
No information about this author
Ayano Katsura,
No information about this author
Koichi Takagaki
No information about this author
et al.
BMC Oral Health,
Journal Year:
2024,
Volume and Issue:
24(1)
Published: Aug. 2, 2024
Hyposalivation
is
treated
using
oral
cholinergic
drugs;
however,
systemic
side
effects
occasionally
lead
to
discontinuation
of
treatment.
We
aimed
investigate
the
transdermal
pilocarpine
on
salivary
gland
skin
saliva
secretion
and
safety
in
rats.
Pilocarpine
was
administered
rats
orally
(0.5
mg/kg)
or
topically
(5
mg/body).
Saliva
volume,
number
sweat
dots,
fecal
weight
were
measured
along
with
concentration
plasma
submandibular
tissues.
volume
significantly
increased
0.5
h
after
administration
0.5,
3,
12
topical
administration.
Fecal
dots
1
administration;
no
changes
observed
application.
The
tissues
group
higher
than
that
at
application
persistently
without
inducing
sweating
diarrhea.
Transdermal
applied
over
glands
may
be
an
effective
safe
treatment
option
for
hyposalivation.
Language: Английский