Creative Education Studies, Journal Year: 2024, Volume and Issue: 12(12), P. 261 - 267
Published: Jan. 1, 2024
Language: Английский
Organoids, Journal Year: 2024, Volume and Issue: 3(4), P. 247 - 265
Published: Oct. 3, 2024
Tooth and periodontal organoids from stem progenitor cells represent a significant advancement in regenerative dentistry, offering solutions for tooth loss diseases. These organoids, which mimic the architecture function of real organs, provide cutting-edge platform studying dental biology developing therapies. Recent methodologies have been developed to optimize conditions organoid production, advancing medicine, disease modeling, developmental studies. The integration bioengineering strategies with culture techniques enhances both our understanding therapeutic potential these organoids. Additionally, factors such as extracellular matrix, growth factors, systems profoundly influence formation maturation. This review explores various approaches generating emphasizing pivotal role cells.
Language: Английский
Citations
2
Dentistry Journal, Journal Year: 2024, Volume and Issue: 12(5), P. 145 - 145
Published: May 16, 2024
The present systematic review was performed to assess the application of orally derived stem cells in periodontal regenerative therapy, and because this, following PICO question proposed: “In patients with periodontitis, can adjunctive use provide additional clinical radiographic benefits for regeneration?”. Randomized studies were electronically manually searched up until December 2023. Quantitative analyses aim evaluating mean differences (MDs) between treatment control groups terms attachment level (CAL) gain, probing pocket depth (PPD) reduction, gingival recession (GR), bone gain (RBG) using random effect models. A total seven selected review. Meta-analyses excluding a high risk bias highlighted non-statistically significant result when compared CAL [MD = 1.05; 95% CI (−0.88, 2.97) p 0.29] PPD reduction 1.32; (−0.25, 2.88) 0.10]. same also applied GR −0.08; (−0.79, 0.63) 0.83] RBG 0.50; 1.88) 0.48]. Based on heterogeneity, there is not enough evidence consider mesenchymal as preferential approach treatment, standard procedures.
Language: Английский
Citations
1
Stem Cells Translational Medicine, Journal Year: 2024, Volume and Issue: 13(10), P. 1028 - 1039
Published: Aug. 24, 2024
The potential of stem cells, for example upper periodontal ligament cells from the maxilla (u-PDLSC) and mandible (l-PDLSC), adipose-derived mesenchymal (AD-MSC), bone marrow-derived (BM-MSC), with respect to remodeling orthodontic treatment is great importance. In this work, we focus on comprehensive adaptability different cell types mechanical forces aim better understanding behavior refine a new mechanistic approach investigate remodeling. We comprehensively analyze observe distinct morphological proliferation changes under compression in dependence type. signaling extracellular signal-regulated kinase (ERK) protein B, also called AKT, their respective phosphorylation shows diverse responses compression. Additionally, vascular endothelial growth factor hepatocyte secretion were reduced stress all types, cell-specific variations. Osteoprotegerin was compression, particularly u-PDLSC. At least, soluble receptors NF-kB-ligand patterns among pressure observed, providing crucial insights into metabolism. These findings offer deeper stimuli, highlighting roles remodeling, wound healing, tissue regeneration regenerative medicine contexts. Our results underscore u-PDLSC, l-PDLSC, AD-MSC regeneration, showing notable resilience indicating its promising role further investigation research. While these are encouraging, research essential fully comprehend mechanism cell-based therapies.
Language: Английский
Citations
1
Journal of Oral and Maxillofacial Surgery Medicine and Pathology, Journal Year: 2024, Volume and Issue: 36(5), P. 665 - 671
Published: Feb. 28, 2024
Language: Английский
Citations
0
Journal of Applied Pharmaceutical Science, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Periodontitis presents as a sustained deterioration of the periodontium, ultimately resulting in tooth loss. Lumbricus rubellus, taxonomically recognized species commonly called earthworm, is significant component natural constituents. This extraordinary organism exhibits intrinsic characteristics that confer antibacterial and anti-inflammatory capabilities. Nevertheless, it essential to acknowledge only restricted subset these pharmaceutical compounds has undergone meticulous scrutiny through clinical trials despite potential effectiveness L. rubellus treatment periodontitis. The present investigation utilizes Scopus database conduct bibliometric examination antioxidant diverse strains rubellus. evaluation performed utilization RStudio VOSviewer applications. Consequently, 55 papers were encompassed within ultimate dataset. Moscow State University widely acknowledged highly productive academic institution with global contributions. Mihara H extensively author highest level productivity. scholarly publication by et al. 1991 significantly impacted respective scientific discipline. These results provide insights stimulate research collaborations reveal open issues about context periodontitis therapy.
Language: Английский
Citations
0
Dentistry, Journal Year: 2024, Volume and Issue: unknown
Published: May 29, 2024
Gingival tissue engineering aims to regenerate damaged or diseased gingival tissues by applying biomaterials, growth factors, and stem cells. This chapter explores advancements strategies in engineering. It begins introducing the goals anatomy/physiology of gingiva. Biomaterial selection design for scaffolds delivery methods bioactive molecules stimulate are discussed. Stem cells highlighted their role regeneration - isolation, characterization, differentiation. Strategies like cell-based approaches, scaffold-free techniques, hybrids combining cells, scaffolds, factors outlined. Preclinical clinical studies assessing treatment safety/efficacy evaluate outcomes reviewed. Challenges around improving cell viability, integration, function examined. Future directions focus on addressing these challenges. Ethical considerations regulatory aspects addressed ensure responsible translation into practice. provides insights current state prospects regenerative approaches engineering, including potential impact disease oral health promotion.
Language: Английский
Citations
0
Journal of Oral Rehabilitation, Journal Year: 2024, Volume and Issue: 51(12), P. 2664 - 2674
Published: Sept. 23, 2024
Dental pulp stem cells (DPSCs) have been extensively used for tissue regeneration owing to their notable capabilities. Insulin-like growth factor-binding protein 5 (IGFBP5) regulates osteogenic differentiation of mesenchymal (MSCs); however, the underlying regulatory mechanisms require further investigation.
Language: Английский
Citations
0
Creative Education Studies, Journal Year: 2024, Volume and Issue: 12(12), P. 261 - 267
Published: Jan. 1, 2024
Language: Английский
Citations
0