Retinol-Binding Protein 4 and Visfatin Levels in Patients with Periodontitis and Obesity/Overweight: A Systematic Review and Meta-Analysis DOI Creative Commons
Yuwei Zhang, Ru Jia, Yifei Zhang

et al.

Current Issues in Molecular Biology, Journal Year: 2023, Volume and Issue: 45(12), P. 9838 - 9850

Published: Dec. 7, 2023

Prior studies demonstrated an equivocal conclusion about the association between level of retinol-binding protein 4 (RBP4)/visfatin and periodontitis patients with obesity. The aim our study (Prospero ID: CRD42023469058) was to systematically review available articles linking biofluid levels RBP4/visfatin comorbidity Clinical trials were screened in accordance specific inclusion criteria from seven databases up November 2023. A quality assessment performed Newcastle–Ottawa Scale ROBINS-I tools for observational interventional trials, respectively. standard mean difference (SMD) a 95% confidence interval (CI) related RBP4 recorded; other indicators visfatin measured via (MD) corresponding CI, Fisher’s Z transformation reveal using Review Manager 5.4. current evidence based on five two studies. All them included systematic review, six meta-analysis. Statistical analysis indicated that there no significant circulating obesity or without, who labeled as OP NP, respectively (155 OP-107 NP: SMD = 1.38; CI: −0.18–2.94, p 0.08), well periodontal healthy normal weight, labelled NnP (116 OP-79 NnP: 6.76; −5.34–18.87, 0.27). Meanwhile, higher serum found than NP (86 OP-45 MD 4.21; 2.65–5.77, < 0.00001)/NnP (164 OP-88 13.02; 7.34–18.70, 0.00001) group. In addition, positive observed body mass index/clinical attachment loss (CAL). And, then, parameters, including probing depth, CAL, plaque index, metabolic total cholesterol, triglycerides, fasting blood glucose, low-density lipoprotein cholesterol. Here, not independently obesity, while significantly associated Notably, parameters/metabolic parameters firmly suggested severity obese status elevated With more rigorous longitudinal research, exact causations affected by could be disentangled. might novel, enlightening prospective bio-indexes targeted treatment comorbidities.

Language: Английский

Cytokines in gingivitis and periodontitis: from pathogenesis to therapeutic targets DOI Creative Commons

Nicole Neurath,

Marco Kesting

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 26, 2024

Chronic inflammatory processes in the oral mucosa and periodontitis are common disorders caused by microflora microbial biofilms. These factors activate both innate adaptive immune systems, leading to production of pro-inflammatory cytokines. Cytokines known play a crucial role pathogenesis gingivitis have been proposed as biomarkers for diagnosis follow-up these diseases. They can stromal cells, local inflammation tissue damage. This damage include destruction periodontal ligaments, gingiva, alveolar bone. Studies reported increased levels cytokines, such interleukin-1beta (IL-1beta), tumor necrosis factor (TNF), IL-6, IL-17, IL-23, patients with periodontitis. In experimental models periodontitis, TNF IL-23/IL-17 axis pivotal disease pathogenesis. Inactivation pathways through neutralizing antibodies, genetic engineering or IL-10 function has demonstrated reduce activity. review discusses cytokines particular emphasis on their mediating destruction. It also explores new therapeutic interventions that offer potential research clinical therapy chronic

Language: Английский

Citations

16
Association between periodontitis and inflammatory comorbidities: The common role of innate immune cells, underlying mechanisms and therapeutic targets DOI

Qibing Wu,

Weijia Zhang,

Yaqiong Lu

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 128, P. 111558 - 111558

Published: Jan. 23, 2024

Language: Английский

Citations

15
Effect of Adiponectin on the Expression of Selected Cytokines in Periodontal Ligament Cells DOI Creative Commons
Małgorzata Kozak, Agata Poniewierska-Baran, Michał Czerewaty

et al.

Biology, Journal Year: 2025, Volume and Issue: 14(4), P. 321 - 321

Published: March 21, 2025

Periodontitis is a disease caused by bacterial infection that causes chronic inflammation. The pathogenesis of periodontitis mediated several mediators, including chemokines, cytokines, metalloproteinases, and adipokines. Adiponectin an adipokine influences metabolic processes numerous immunological processes. In this study, we investigated the effect adiponectin on expression in periodontal ligament selected cytokines involved periodontitis. Human cells (hPDLCs) were stimulated with then analyzed for (TNF-α, IL-1, IL-6, IL-8, IL-10, IL-17, IL-18) cell cultures at mRNA level supernatants protein level. samples after 12, 24, 48 h stimulation. We found no significant TNF-α gene For statistically increase IL-1 was 12 stimulation, while differences not 24 h. IL-6 Stimulating significantly increased TNF-α, IL-8 levels There IL-18 levels. results our study suggest may cells.

Language: Английский

Citations

0
The Influence of Diet and Physical Activity on Periodontal Health: A Narrative Review DOI Creative Commons
Giuseppe Balice, Michele Paolantonio, Giovanna Murmura

et al.

Dentistry Journal, Journal Year: 2025, Volume and Issue: 13(5), P. 200 - 200

Published: April 30, 2025

Periodontal diseases, including gingivitis and periodontitis, are chronic inflammatory conditions that compromise the supporting structures of teeth, often leading to tooth loss contributing systemic comorbidities. Increasing evidence underscores critical role modifiable lifestyle factors, particularly diet physical activity, in influencing periodontal health. This narrative review critically evaluates current body literature regarding impact dietary constituents activity on periodontium, with a focus molecular mechanisms, key biomarkers, clinical implications. It aims provide deeper understanding complex interactions between nutrition, exercise, health potential implications for management preventive strategies.

Language: Английский

Citations

0
Molecular mechanisms of obesity predisposes to atopic dermatitis DOI Creative Commons

Dao-hui Shang,

Shengnan Zhao

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 4, 2024

Obesity is a prevalent metabolic disease that reduces bacterial diversity, colonizes the epidermis with lipophilic bacteria, and increases intestinal pro-inflammatory species, all of which lead to impaired epithelial barriers. Adipose tissue secretes immunomodulatory molecules, such as adipokines, leptin, adiponectin, alters morphology adipocytes macrophages well modulates T cell differentiation peripheral Th2-dominated immune responses. Atopic dermatitis (AD) obesity have similar pathological manifestations, including inflammation insulin leptin resistance. This review examines major mechanisms between AD, focus on effect skin gut microbiota, responses mediated by toll like receptor (TLR) signaling pathway, changes in cytokine levels (TNF-a, IL-6, IL-4, IL13). Moreover, we describe potential effects adipokines AD finally PPAR-γ suppresses regulates type 2 immunity.

Language: Английский

Citations

3
Periodontal Treatment During the Blanking Period Improves the Outcome of Atrial Fibrillation Ablation DOI Creative Commons
Shunsuke Miyauchi, Kazuhisa Ouhara, Tomoaki Shintani

et al.

Journal of the American Heart Association, Journal Year: 2024, Volume and Issue: 13(8)

Published: April 10, 2024

Background Periodontitis has not been recognized as a modifiable risk factor for atrial fibrillation (AF). This prospective nonrandomized study investigated whether periodontal treatment improves the AF ablation outcome. Methods and Results We prospectively enrolled 288 patients scheduled to undergo initial radiofrequency catheter ablation. Each patient underwent inflamed surface area (PISA; quantitative index of inflammation) measurement. All eligible were recommended receive within blanking period, 97 consented. During mean follow‐up period 507±256 days, 70 (24%) recurrences documented. Patients who exhibited had higher PISA than those did (456.8±403.5 versus 277.7±259.0 mm 2 , P =0.001). These categorized into high‐PISA (>615 ) low‐PISA (<615 groups according receiver operating characteristic analysis recurrence (area under curve, 0.611; sensitivity, 39%; specificity, 89%). A high PISA, well female sex, duration, left volume, statistically significant predicter (hazard ratio [HR], 2.308 [95% CI, 1.234–4.315]; =0.009). In with showed significantly fewer ( =0.01, log‐rank test). The adjusted HR was 0.393 (95% 0.215–0.719; =0.002). Conclusions may serve AF. is hallmark recurrence, outcome, especially poor condition.

Language: Английский

Citations

2
Interplay between periodontitis and chronic kidney disease DOI
Iain Chapple, Josefine Hirschfeld, Paul Cockwell

et al.

Nature Reviews Nephrology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 10, 2024

Language: Английский

Citations

2
Association between Periodontal Disease and Obesity: Umbrella Review DOI Creative Commons
Heber Arbildo‐Vega, Fredy Hugo Cruzado-Oliva, Franz Tito Coronel Zubiate

et al.

Medicina, Journal Year: 2024, Volume and Issue: 60(4), P. 621 - 621

Published: April 11, 2024

Objective: Determine the association between periodontal disease (PD) and obesity through an umbrella review. Materials Methods: A search for information until March 2024 was carried out in following electronic databases: PubMed, Cochrane library, Scopus, SciELO, Web of Science, Google Scholar, Proquest Dissertations Theses, OpenGrey. We included studies that were systematic reviews (SR) with or without meta-analysis, time language restrictions, evaluated primary associated PD obesity. Literary narrative reviews, rapid intervention studies, observational preclinical basic research, summaries, comments, case reports, protocols, personal opinions, letters, posters excluded. The AMSTAR-2 tool used to determine quality overall confidence studies. Results: preliminary yielded a total 419 articles, discarding those did not meet selection criteria, leaving only 14 articles. All reported obesity, OR RR ranging from 1.1 1.46 1.64 2.21, respectively. Conclusions: Based on results conclusions SR high level, is

Language: Английский

Citations

1
Role of circulating microparticles and cytokines in periodontitis associated with diabetes DOI Creative Commons

Bárbara Adelungue Cassiano,

Ana Luíza Pereira Assunção Silveira,

Yeon‐Jung Kim

et al.

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Aug. 26, 2024

Background Periodontitis is a chronic inflammatory condition that affects the supporting tissues of teeth, and can lead to serious complications such as tooth loss systemic health problems, including diabetes, which have bidirectional relationship with periodontitis. Circulating microparticles originate from different cell types after stimuli activation or apoptosis. Interleukins are related processes in regulation immune response, inflammation, growth. This study aimed evaluate circulating well interleukins plasma, at baseline 1 month end non-surgical periodontal treatment. Methods Samples were collected 45 patients, moderate severe periodontitis diabetes ( N = 25) without 20). Microparticles evaluated platelet-poor plasma by flow cytometer. Cytokine levels enzyme immunoabsorption assay (ELISA). Results Higher pro-inflammatory cytokines found group compared non-diabetic both A higher IL-6/IL-10 ratio was patients T0 T1, whereas an increased IFN-γ/IL-10 only T1 comparison diabetes. In it verified positive correlations between IL-10 IL-6 IFN-γ negative correlation PMP, T0; contrast, TNF-α PMP. Besides, T0, evidenced IL-6, EMP, PMP addition, observed IFN-γ, IL-10, EMP this group. Conclusion The results suggest modulatory effect associated treatment, status participants study.

Language: Английский

Citations

1
Research progress on the potential correlation between polycystic ovary syndrome and periodontal disease DOI Creative Commons

H. Zhang,

Xiaoping Lin

Journal of International Medical Research, Journal Year: 2024, Volume and Issue: 52(11)

Published: Nov. 1, 2024

Over the past few years, correlation between periodontal disease (PD) and polycystic ovary syndrome (PCOS) has attracted widespread attention owing to increased incidence of these diseases. Several studies have suggested a possible link two. In this narrative review, we examined epidemiology, common risk factors, pathological mechanisms PCOS PD investigate potential association Evidence from literature indicates that can interact with each other. Common such as microbial homeostasis imbalance dysbiosis, along multiple hormone inflammatory mediators, well responses oxidative stress ferroptosis, are all associated pathogenesis both Further needed clarify specific interaction PD, which could future directions in management combined multidisciplinary treatment.

Language: Английский

Citations

1