Innovative anti-fibrotic strategy using a bromelain containing mucoadhesive patch for effective collagen breakdown and cytotoxicity in oral submucous fibrosis DOI
Atul Anand Bajoria,

Nandita Parida,

Rekha Rani Kokkanti

et al.

Materials Today Communications, Journal Year: 2024, Volume and Issue: unknown, P. 111307 - 111307

Published: Dec. 1, 2024

Language: Английский

Aloe vera―An Extensive Review Focused on Recent Studies DOI Creative Commons
Alessia Catalano, Jessica Ceramella, Domenico Iacopetta

et al.

Foods, Journal Year: 2024, Volume and Issue: 13(13), P. 2155 - 2155

Published: July 8, 2024

Since ancient times,

Language: Английский

Citations

13
Expression and correlation of the long noncoding RNA PDIA3P and FAK/TGF-β pathway in oral submucous fibrosis rats DOI

Fu Zhu,

Y. Li,

Ribo Guo

et al.

Journal of Stomatology Oral and Maxillofacial Surgery, Journal Year: 2025, Volume and Issue: unknown, P. 102214 - 102214

Published: Jan. 1, 2025

Language: Английский

Citations

0
Epigallocatechin-3-gallate inhibits the collagen accumulation of oral submucous fibrosis induced by arecoline DOI Creative Commons
Ge Gao, Chih-Hung Lin,

Ruibo Li

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 31, 2025

Oral submucous fibrosis (OSF) is a chronic oral mucosal disease, which exerts profound impact on patients' daily life and currently lacks efficacious therapeutic interventions. Epigallocatechin-3-gallate (EGCG), the abundant polyphenol found in green tea, exhibits remarkable anti-fibrotic effects skin. However, research OSF regarding EGCG relatively limited. We aimed to investigate potential effect of against using an arecoline (ARE) -induced rat model primary fibroblasts. Primary fibroblasts (ROMF) were isolated identified. Optimal ARE concentrations established Cell Counting Kit-8. The extracellular matrix (ECM)-related protein expression was assessed through RT-qPCR Western blot techniques. Similarly, ARE-induced ECM changes ROMF evaluated. study also Sprague-Dawley rats, induced by ARE, with pathological characterized HE Masson's staining, further assessing ECM-related tissues methods. effectively suppressed components while concurrently improving process vitro vivo. results indicate that natural product increased improved process, indicating could be potentially novel candidate drug for treatment OSF.

Language: Английский

Citations

0
The effectiveness of interpositional grafts in surgical management of advanced oral submucous fibrosis (OSMF): a systematic review with meta-analysis DOI Creative Commons
Varsha Sunil Manekar, M. Kataria, P. S. Shetty

et al.

Journal of Oral Medicine and Oral Surgery, Journal Year: 2025, Volume and Issue: 31(1), P. 9 - 9

Published: Jan. 1, 2025

Background: The management of OSMF aims to alleviate the signs and symptoms, such as burning sensation release fibrotic bands assist oral opening. Surgical excision is best choice in treatment advanced OSMF. Interpositional grafts are used cover raw surgical defects following bands' excision. They can be local (tongue flap, palatal island buccal fat pad, nasolabial temporalis fascia flap) or distant (abdominal dermal graft, anterolateral thigh flap). This systematic review was conducted evaluate which type interpositional graft effective submucous fibrosis. Material method: A Literature search performed 12 electronic databases for articles published between 2000, August 31, 2023. Two reviewers independently reviewed articles. Ten (Non randomized controlled trial (NRCT)-5 (RCT)-5) were selected based on inclusion criteria. For NRCTs, Joanna Briggs Institute Critical Appraisal Checklist Quasi-Experimental Studies ROB b tool RCT risk bias. Results: studies exclusion It included; 5 NRCTs RCTs. Meta-analysis performed, mouth opening greater subjects treated with flap than other designs at sixth month 12th follow up. However, difference two groups statistically non-significant ( p = 0.19). Buccal Fat pad also shows successful results but not significant. Conclusion: observations this help enhance awareness among healthcare professionals, clinicians about recommending an cases making use its advantages.

Language: Английский

Citations

0
Tetrahedral framework nucleic acid-based delivery of microRNA-29b: A precision nanotherapeutic strategy for oral submucous fibrosis DOI
Xiao Fu, Mei Zhang,

Chen-Peng Chen

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 163736 - 163736

Published: May 1, 2025

Language: Английский

Citations

0
Formulation, in-vitro characterization and clinical evaluation of curcumin in-situ gel for treatment of oral submucosal fibrosis (OSF) DOI
Chunyu Zeng, Chunyu Zhang, Yuxin Zhang

et al.

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: 679, P. 125762 - 125762

Published: May 26, 2025

Language: Английский

Citations

0
Development of Epigallocatechin 3-gallate-Loaded Hydrogel Nanocomposites for Oral Submucous Fibrosis DOI Creative Commons
Chetan Hasmukh Mehta,

Varalakshmi Velagacherla,

Suman Manandhar

et al.

AAPS PharmSciTech, Journal Year: 2024, Volume and Issue: 25(4)

Published: March 22, 2024

Abstract Oral submucous fibrosis (OSF) is a chronic progressive disease associated with increased collagen deposition and TGF-β1 release. The current therapy management have been limited success due to low efficacy adverse drug reactions. This study aimed evaluate epigallocatechin 3-gallate (EGCG) encapsulated nanoparticles loaded mucoadhesive hydrogel nanocomposite (HNC) for OSF. Developed HNC formulations were evaluated their permeation behaviour using in vitro as well ex vivo studies, followed by evaluation of safety studies areca nut extract-induced OSF rats. condition OSF-induced rats was assessed mouth-opening biochemical markers. optimized polymeric exhibited the required particle size (162.93 ± 13.81 nm), positive zeta potential (22.50 2.94 mV) better strength (0.40 0.002 N), faster interactions positively charged surface negatively buccal mucosal membrane. significantly improved conditions reducing concentration without showing toxicity reverting fibroid mucosa normal. Hence, formulation can be further tested develop clinically alternate therapeutic strategy Graphical

Language: Английский

Citations

2
Hyaluronidase inhibits TGF-β-mediated rat periodontal ligament fibroblast expression of collagen and myofibroblast markers: An in vitro exploration of periodontal tissue remodeling DOI
Junlin Li,

Chen Chen,

Yunting Zeng

et al.

Archives of Oral Biology, Journal Year: 2024, Volume and Issue: 163, P. 105980 - 105980

Published: April 27, 2024

Language: Английский

Citations

2
A scientometric study on research trends and characteristics of oral submucous fibrosis DOI Creative Commons

Chengbin Wei,

Xuemin Shen, Wei Liu

et al.

Journal of Dental Sciences, Journal Year: 2024, Volume and Issue: 19(3), P. 1834 - 1839

Published: May 18, 2024

Oral submucous fibrosis (OSF) affecting populations is considered a public health issue in South/Southeast Asia. The purpose of this study was to analyze the scientometric characteristics and research trends OSF.

Language: Английский

Citations

2
Oral submucosal fibrosis: An updated molecular mechanism on pathogenesis and treatment modalities DOI

Vadivel Jayanth Kumar,

Devaraj Ezhilarasan,

Deepak Nallasamy Veeraiyan

et al.

Oral Diseases, Journal Year: 2024, Volume and Issue: 30(7), P. 4798 - 4799

Published: Feb. 20, 2024

Data sharing is not applicable to this article as no new data were created or analyzed in study.

Language: Английский

Citations

1