Exosomal communication: a pivotal regulator of bone homeostasis and a potential therapeutic target DOI Creative Commons

Qian-Yun Ye,

Yan Cui, Haoyu Wang

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 23, 2024

Bone homeostasis encompasses two interrelated aspects: bone remodeling and cartilage metabolism. Disruption of can lead to the development metabolic diseases such as osteoporosis osteoarthritis. The maintenance is a complex process that does not solely rely on functions tissue itself. In fact, an isolated entity; it closely connected other tissues in body via exosomes. Within this interconnectivity, exosomes derived from both non-bone cells interfere with each other, forming regulatory network. Therefore, cell origin guiding principle, we have delineated network exosomes, elaborated specific roles mechanisms common types (cells within skeletal microenvironment, stem extra-osseous tissues, vascular-derived cells, muscle-derived neurogenic cells) formation, resorption, We also discussed challenges faced field exosome research related homeostasis, unveiled critical role maintaining proposed could serve highly valuable therapeutic targets for diseases.

Language: Английский

Extracellular Vesicles and Exosomes in the Control of the Musculoskeletal Health DOI Creative Commons
Fabio Penna,

Lorena Garcia‐Castillo,

Paola Costelli

et al.

Current Osteoporosis Reports, Journal Year: 2024, Volume and Issue: 22(2), P. 257 - 265

Published: March 1, 2024

The present review will highlight recent reports supporting the relevance of extracellular vesicles to musculoskeletal system in health and disease. Preserving is important maintain a good quality life, bone-muscle crosstalk crucial this regard. This latter largely mediated by released different cell populations residing muscle bone, which deliver cargoes, microRNAs, proteins being most relevant ones, target cells. Extracellular could be exploited as therapeutic tools, view their resistance destruction biological fluid possibility functionalized according need. are recognized players cross-talk. Additional studies however required refine use biomarkers early alterations system, potential tools.

Language: Английский

Citations

3
Bone Regeneration Revolution: Pulsed Electromagnetic Field Modulates Macrophage-Derived Exosomes to Attenuate Osteoclastogenesis DOI Creative Commons
Martina Trentini, Ugo D’Amora, Alfredo Ronca

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 8695 - 8707

Published: Aug. 1, 2024

In the process of bone regeneration, a prominent role is played by macrophages involved in both initial inflammation and regeneration/vascularization phases, due to their M2 anti-inflammatory phenotype. Together with osteoclasts, they participate degradation matrix if inflammatory does not end. this complex scenario, recently, much attention has been paid extracellular communication mediated nanometer-sized vesicles, high information content, called exosomes (EVs). Considering these considerations, purpose present work demonstrate how presence pulsed electromagnetic field (PEMF) can positively affect through EVs.

Language: Английский

Citations

3
Exosomal non-coding RNAs: Emerging insights into therapeutic potential and mechanisms in bone healing DOI Creative Commons

Huixin Shi,

Yang Yang,

Hao Xing

et al.

Journal of Tissue Engineering, Journal Year: 2024, Volume and Issue: 15

Published: Jan. 1, 2024

Exosomes are nano-sized extracellular vesicles (EVs) released by diverse types of cells, which affect the functions targeted cells transporting bioactive substances. As main component exosomes, non-coding RNA (ncRNA) is demonstrated to impact multiple pathways participating in bone healing. Herein, this review first introduces biogenesis and secretion elucidates role cargo ncRNAs, mediating intercellular communication. Subsequently, potential molecular mechanism exosomes accelerating healing elucidated from following four aspects: macrophage polarization, vascularization, osteogenesis osteoclastogenesis. Then, we systematically introduce construction strategies based on modified regeneration field. Finally, clinical trials for challenges exosome-based therapies biomedical field briefly introduced, providing solid theoretical frameworks optimization methods application orthopedics.

Language: Английский

Citations

3
Exosomes secreted from M2-polarized macrophages inhibit osteoclast differentiation via CYLD DOI
Ziyan Guo, Nannan Yin, Xiaofei Li

et al.

Tissue and Cell, Journal Year: 2024, Volume and Issue: 93, P. 102645 - 102645

Published: Nov. 30, 2024

Language: Английский

Citations

0
M2-like macrophage-derived exosomes inhibit osteoclastogenesis via releasing miR-1227-5p DOI Creative Commons

Shan Chen,

Jian Liu, Lilei Zhu

et al.

Immunobiology, Journal Year: 2024, Volume and Issue: 230(1), P. 152861 - 152861

Published: Dec. 7, 2024

Macrophages play a pivotal role in regulating inflammatory response periodontitis, condition characterized by excessive osteoclast differentiation. This study aimed to investigate whether exosomes derived from M2 macrophages regulate differentiation and identify the underlying molecular mechanisms. Exosomes were isolated used treat osteoclasts. Osteoclastogenesis was assessed using tartrate-resistant acid phosphatase staining reverse transcription-quantitative polymerase chain reaction (RT-qPCR). The mechanism evaluated microarray analysis, RT-qPCR, dual-luciferase reporter RNA pull-down assay. results showed that inhibited receptor activator of nuclear factor κ-B ligand (RANKL)-induced Additionally, miR-1227-5p expression osteoclasts increased after treatment with exosomes, inhibition counteracted suppressive effects on osteoclastogenesis. Moreover, OSCAR is target miR-1227-5p. In conclusion, exosomal suppresses differentiation, potentially via targeting OSCAR. These findings provide new insights into pathogenesis periodontitis.

Language: Английский

Citations

0
Exosomal communication: a pivotal regulator of bone homeostasis and a potential therapeutic target DOI Creative Commons

Qian-Yun Ye,

Yan Cui, Haoyu Wang

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 23, 2024

Bone homeostasis encompasses two interrelated aspects: bone remodeling and cartilage metabolism. Disruption of can lead to the development metabolic diseases such as osteoporosis osteoarthritis. The maintenance is a complex process that does not solely rely on functions tissue itself. In fact, an isolated entity; it closely connected other tissues in body via exosomes. Within this interconnectivity, exosomes derived from both non-bone cells interfere with each other, forming regulatory network. Therefore, cell origin guiding principle, we have delineated network exosomes, elaborated specific roles mechanisms common types (cells within skeletal microenvironment, stem extra-osseous tissues, vascular-derived cells, muscle-derived neurogenic cells) formation, resorption, We also discussed challenges faced field exosome research related homeostasis, unveiled critical role maintaining proposed could serve highly valuable therapeutic targets for diseases.

Language: Английский

Citations

0