Vitamin A family suppresses periodontitis by restoring mitochondrial metabolic reprogramming in macrophages through JAK-STAT pathway

Frontiers in Genetics, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 28, 2025

Objective Mitochondrial metabolic reprogramming in macrophages is crucial the development and progression of inflammation. Given vitamin A’s antioxidant properties its therapeutic effects on inflammation, this study aims to elucidate how A influences mitochondrial inflammatory states, specifically periodontitis, through genetic bioinformatics experimental methods. Method The utilized GSE16134 dataset from Gene Expression Omnibus (GEO) database, focusing human periodontitis. Vitamin A-targeted genes (ATGs) were identified analyzed using CIBERSORT explore their role Cluster analysis revealed two phenotypes associated with ATGs, showing differential expression like COX1, IL-1β , STAT3 immune activation patterns. Weighted Co-expression Network Analysis (WGCNA) 145 markers correlated ATG-guided Machine learning models, combined Set Variation (GSVA), five key ( RGS1, ACAT2, KDR, TUBB2A, TDO2 ) linked Cell Type-Specific Enrichment (CSEA) highlighted as critical reprogramming, validated by external datasets an AUC 0.856 GSE10334 0.750 GSE1730678. Experimental validation showed suppressing endoplasmic reticulum stress altering dynamics, well influencing inflammation via pathway RAW 264.7 cells. Results 13 differentially expressed ATGs strong correlations particularly plasma cells, macrophages, dendritic neutrophils, mast Two identified, differing gene activation. WGCNA machine models GSVA CSEA analyses JAK-STAT macrophage involvement reprogramming. data confirmed dynamics pathway. Conclusion demonstrates that effect periodontitis mediated pathway-guided macrophages. It identifies immune-related identifiers risk.

Language: Английский

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The Role of Vitamin B Complex in Periodontal Disease: A Systematic Review Examining Supplementation Outcomes, Age Differences in Children and Adults, and Aesthetic Changes

Nutrients, Journal Year: 2025, Volume and Issue: 17(7), P. 1166 - 1166

Published: March 27, 2025

Background and Objectives: Among nutritional factors implicated in periodontal health, the vitamin B complex-particularly folate (vitamin B9), cobalamin (B12), thiamine (B1), riboflavin (B2)-has gained attention for its role immunomodulation tissue repair. This systematic review aims to synthesize current evidence on whether adequate complex intake or status is associated with improved outcomes. Methods: A search was performed PubMed, Scopus, Web of Science observational studies investigating relation disease indicators. Articles were screened according PRISMA guidelines, five met inclusion criteria. Results: Five included. In older adults, each standard deviation increase serum an approximate 26% reduction odds ratio (OR = 0.74, 95% confidence interval (CI) 0.58-0.93). young adult women, inadequate (B2) pyridoxine (B6) correlated higher community index (CPI) scores (p < 0.05). a large NHANES-based cohort, insufficient (B1) yielded 33% likelihood severe periodontitis 0.05), while protective 0.90). Another dose-response analysis (n 8959) indicated up 30% risk moderate B1 intake, but no extra benefit excessive intake. Finally, UK Biobank 9476) showed that those highest quartile "high micronutrient" dietary pattern-including vitamins B6 folate-had 24% lower self-reported 0.76, CI 0.65-0.90) compared lowest quartile. Conclusions: Across diverse populations, intake-especially folate-was consistently linked worse

Language: Английский

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Micronutrients and the Periodontium: A Narrative Review

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: April 4, 2025

This is a comprehensive narrative assessment of micronutrient relevance for periodontal health. The periodontium crucial and intricate structure that supports the tooth within alveolar bone. Composed four tissues with distinct embryological origins- bone, cementum, gingiva, ligament - plays fundamental role in maintaining dento-alveolar function homeostasis. Periodontitis gaining attention due to its widespread occurrence worldwide. inflammatory condition disrupts balance between host immune response microbial virulence factors. Connective tissue production defenses require proteins Vegetable support health by promoting repair function, while excessive dietary fats can exacerbate inflammation increase risk disease (PD). Inflammation further compounded animal fats, which contribute PD. Omega-3 fatty acids are well-known their anti-inflammatory effects, help reduce inflammation. Adequate intake essential minerals vitamins required Vitamins K, D, A oral epithelial integrity, facilitating bone development, supporting overall maintenance. Inadequate calcium (Ca²⁺) magnesium (Mg²⁺) levels have been associated severe Antioxidants such as vitamin C alleviate tissues. As recognized dental professionals, nutritional status considerable an individual's developing

Language: Английский

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The Impact of Nutritional Components on Periodontal Health: A Literature Review

Nutrients, Journal Year: 2024, Volume and Issue: 16(22), P. 3901 - 3901

Published: Nov. 15, 2024

Periodontitis is a chronic inflammatory disease driven by the accumulation of bacterial plaque and host's immune response, leading to destruction periodontal tissues. Nutrition, particularly intake micronutrients with anti-inflammatory antioxidant properties, plays crucial role in maintaining health. This review explores impact various micronutrients-vitamins (A, B, C, D, E), minerals (calcium, iron, zinc, potassium, copper, manganese, selenium), omega-3 fatty acids-on prevention management. Deficiencies these nutrients can exacerbate tissue damage impairing responses, promoting oxidative stress, reducing bone regeneration capabilities. While certain populations may be more vulnerable deficiencies, such as those following Western diets or living low- middle-income countries, even developed nations, suboptimal nutrient associated worse outcomes. Although some studies suggest that supplementation specific benefit therapy, evidence remains inconclusive, necessitating further randomized clinical trials. underscores importance considering nutritional guidance treatment protocols highlights need for tailored recommendations based on recent findings.

Language: Английский

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Potential Associations Between Vitamin Intake and Leukemia: A Cross-Sectional Study

Nutrition and Cancer, Journal Year: 2024, Volume and Issue: 76(10), P. 1001 - 1007

Published: July 24, 2024

The present study assessed potential associations between vitamin intake and leukemia in a national sample of adults the United States. A total 5520 participants were included this cross-sectional to investigate relationship (including vitamins A, C, D, E) leukemia. Results revealed negative C E leukemia, whereas D not statistically significant. For compared with first tertile, odds ratio (OR) corresponding 95% confidential interval (CI) was 0.90 (0.75-0.95) for second tertile 0.82 (0.61-0.90) third (

Language: Английский

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Low folate biomarker concentrations are associated with increase the risk and severity of periodontitis in adults: A cross–sectional study based on the National Health and Nutrition Examination Survey 2009–2014

Nutrition Research, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

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Impact of Tocopherol Supplementation on Clinical Parameters of Periodontal Disease: A Systematic Review and Meta-Analysis

Journal of Personalized Medicine, Journal Year: 2024, Volume and Issue: 14(10), P. 1039 - 1039

Published: Sept. 28, 2024

Background and Objectives: The significance of periodontal disease as a public health issue prompts the exploration effective treatments, including potential use tocopherol (Vitamin E) due to its anti-inflammatory antioxidant properties. Materials Methods: PICO statement (Population, Intervention, Comparator, Outcome) was follows: In patients with disease, does supplementation compared no or insufficient Vitamin E intake improve clinical outcomes such gingival inflammation, pocket depth, attachment levels? This study searched through PubMed, Scopus, Web Science up June 2024 focused on studies involving human subjects various forms analyzing impact dietary supplementary intake. Primary evaluated included improvements in levels, data synthesis conducted according PRISMA (Preferred Reporting Items for Systematic Reviews Meta-Analyses) guidelines. Quality assessment risk bias were meticulously performed observational randomized controlled trials. Results: meta-analysis incorporated 8 that used extraction, totaling 12,832 patients, revealing heterogeneous response supplementation, pooled odds ratio efficacy reducing severity at about 0.97 (95% CI: 0.96–0.98). Noteworthy findings indicated statistically significant increase loss depth ratios ranging from 1.15 9.33 when insufficient. However, considerable heterogeneity (I2 = 88.35%) underscores variations tocopherol’s effectiveness across different populations designs. Conclusions: While shows modest benefit managing particularly levels variability emphasizes necessity more research establish standardized treatment protocols dosages.

Language: Английский

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Evaluating the Protective Role of Vitamin A Supplementation in Periodontal Health: A Comprehensive Systematic Review and Meta-Analysis

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(16), P. 4775 - 4775

Published: Aug. 14, 2024

Background: Recent studies suggest a potential role for vitamin A supplementation in improving periodontal health, though evidence remains inconclusive. This systematic review and meta-analysis aimed to evaluate the protective of on focusing outcomes such as gingival inflammation, pocket depth reduction, alveolar bone preservation. Methods: literature search was conducted PubMed, Scopus, Web Science up until May 2024, adhering strict inclusion criteria that required involve human participants diagnosed with diseases assess impact through dietary intake or supplementation. excluded not explicitly focused those lacking clear, quantifiable outcomes. The risk bias assessed using Newcastle–Ottawa Scale observational Cochrane Collaboration’s tool randomized controlled trials. Meta-analysis performed synthesize data quantify effectiveness health Results: total six were included final analysis 50,722 participants. revealed pooled odds ratio (OR) 0.97 (95% CI: 0.94–1.00) association between indicating slight effect. Notably, two high-quality reported ORs 0.92 0.85–1.00) 0.83 0.69–1.00), respectively, suggesting reduction disease sufficient levels. However, high heterogeneity (I2 = 86.93%) across indicates variability outcomes, possibly influenced by demographic lifestyle factors. Conclusions: Vitamin may offer marginal effect against disease, although results vary significantly different populations study designs. Further research is needed clarify these relationships explore mechanisms which influences considering degree observed heterogeneity.

Language: Английский

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