Preclinical in vitro models of HNSCC and their role in drug discovery - an emphasis on the cancer microenvironment and microbiota DOI Creative Commons
Anne‐Sophie Becker, Sonja Oehmcke-Hecht,

Erik Dargel

et al.

Expert Opinion on Drug Discovery, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 21

Published: Dec. 15, 2024

Head and neck squamous cell carcinoma (HNSCC) is the seventh most common cancer worldwide. Treatment options patient outcomes have not improved significantly over past decades, increasing need for better preclinical models. Holistic approaches that include an intact functional immune compartment along with patient's individual tumor microbiome will help improve predictive value of novel drug efficacy.

Language: Английский

Current Evidence on the Relation Between Microbiota and Oral Cancer—The Role of Fusobacterium nucleatum—A Narrative Review DOI Open Access

Federica Chiscuzzu,

Claudia Crescio,

Simona Varrucciu

et al.

Cancers, Journal Year: 2025, Volume and Issue: 17(2), P. 171 - 171

Published: Jan. 7, 2025

Oral squamous cell carcinoma (OSCC) is one the most prevalent head and neck cancers represents a major cause of morbidity mortality worldwide. The main established risk factors for OSCC include tobacco alcohol consumption betel quid chewing, which may contribute alone or in combination with other environmental to carcinogenesis. oral microbiota emerging as key player establishment molecular cellular mechanisms that trigger promote carcinogenesis, including cavity. Among bacterial species found microbiota, Fusobacterium nucleatum, an anaerobic bacterium commonly biofilms periodontal pathogen, has gained attention due solid evidence implicating F. nucleatum colorectal cancer (CRC). been shown induce chronic inflammation, proliferation invasion while deploying immune evasion mechanisms. These experimental findings were first obtained vitro vivo models CRC are being confirmed studies on OSCC. In this review, we summarize recent role OSCC, discuss clinical implications terms prognosis provide overview involved. Moreover, identify research questions aspects require investigations clarify We anticipate field have significant impact diagnosis, management

Language: Английский

Citations

0
Dysbiosis of Oral Microbiome: A Key Player in Oral Carcinogenesis? A Critical Review DOI Creative Commons
K. Devaraja, Sadhna Aggarwal

Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 448 - 448

Published: Feb. 12, 2025

The oral cavity is known to harbor hundreds of microorganisms, belonging various genera, constituting a peculiar flora called the microbiome. change in relative distribution constituents this microbial flora, due any reason, leads dysbiosis. For centuries, dysbiosis has been linked etiopathogenesis several medical illnesses, both locally and systemically-. However, aided by recent advent bio-technological capabilities, reports have re-emerged that link carcinogenesis, numerous studies are currently exploring their association plausible mechanisms. Some proposed mechanisms dysbiosis-induced carcinogenesis (ODIC) include—a bacteria-induced chronic inflammatory state leading direct cellular damage, inflammatory-cytokine-mediated promotion proliferation invasion, release bacterial products carcinogenic, suppression local immunity alteration tumor microenvironment. actual interactions between these role not yet fully understood. This review provides comprehensive overview hypotheses implicated ODIC, along with corresponding molecular aberrations. Apart from discussing usual microbiome profile, also summarizes profiles ODIC. sheds light on potential clinical implications research prevention management cancer.

Language: Английский

Citations

0
Intratumoral Fusobacterium nucleatum is associated with better cancer-specific survival in head and neck cancer patients DOI Creative Commons
José Guilherme Datorre, Mariana Bisarro dos Reis, Bruna Pereira Sorroche

et al.

Journal of Oral Microbiology, Journal Year: 2025, Volume and Issue: 17(1)

Published: April 1, 2025

The oral microbiome, particularly Fusobacterium nucleatum (Fn), has been implicated in head and neck cancers (HNC), influencing local immunity Human Papillomavirus (HPV) status. Here, we evaluated the presence of Fn its association with HPV infection, TERT promoter (TERTp) mutations, patient outcomes. We analyzed 94 formalin-fixed paraffin-embedded (FFPE) tumor tissues from HNC patients previously for TERTp mutations. DNA was detected using droplet digital PCR (ddPCR), status determined via p16 immunohistochemistry pre-treatment samples. Associations between presence, clinicopathological features, HPV, mutation were assessed. Tumors primarily originated oropharynx (70.2%) cavity (29.8%). Tobacco alcohol use reported 87.2% 79.8% cases, respectively. present 59.6% higher prevalence oropharyngeal (62.1%) than (53.6%) tumors. No significant associations found TERTp, or However, positivity showed significantly improved cancer-specific survival (61.5% vs. 39.1%, p = 0.013), similar to HPV-positive (72.7% 42.7%, 0.014). correlates longer survival, highlighting potential as a prognostic marker.

Language: Английский

Citations

0
Metabolic targeting of regulatory T cells in oral squamous cell carcinoma: new horizons in immunotherapy DOI Creative Commons

Menglai Gan,

Naiming Liu, Wenting Li

et al.

Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)

Published: Dec. 19, 2024

Oral squamous cell carcinoma (OSCC) is a prevalent oral malignancy, which poses significant health risks with high mortality rate. Regulatory T cells (Tregs), characterized by their immunosuppressive capabilities, are intricately linked to OSCC progression and patient outcomes. The metabolic reprogramming of Tregs within the tumor microenvironment (TME) underpins function, key pathways such as tryptophan-kynurenine-aryl hydrocarbon receptor, PI3K-Akt-mTOR nucleotide metabolism significantly contributing suppressive activities. Targeting these offers novel therapeutic approach reduce Treg-mediated immunosuppression enhance anti-tumor responses. This review explores dependencies that sustain Treg function in OSCC, highlighting adaptations glycolysis, fatty acid oxidation, amino signaling pathway enable thrive challenging conditions TME. Additionally, discusses influence microbiome on evaluates potential strategies targeting pathways. Despite promising interventions, challenges selectivity, toxicity, heterogeneity, resistance mechanisms remain. concludes perspectives personalized medicine integrative approaches, emphasizing need for continued research translate findings into effective clinical applications treatment.

Language: Английский

Citations

2
Effects of intratumoral microbiota on tumorigenesis, anti-tumor immunity, and microbe-based cancer therapy DOI Creative Commons
Jingwei Zheng, Hao Chen

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: Sept. 26, 2024

Intratumoral microbiota (IM) has emerged as a significant component of the previously thought sterile tumor microenvironment (TME), exerting diverse functions in tumorigenesis and immune modulation. This review outlines historical background, classification, diversity IM, elucidating its pivotal roles oncogenicity, cancer development, progression, alongside influence on anti-tumor immunity. The signaling pathways through which IM impacts immunity, including reactive oxygen species (ROS), β-catenin, stimulator interferon genes (STING), other [NF-κB, Toll-like receptor (TLR), complement, RhoA/ROCK, PKR-like ER kinase (PERK)], are discussed comprehensively. Furthermore, we briefly introduce clinical implications emphasizing potential target for novel therapies, diagnostic biomarkers, prognostic indicators. Notably, microbe-based therapeutic strategies such fecal microbiome transplantation (FMT), probiotics regulation, bacteriotherapy, bacteriophage therapy, oncolytic virotherapy highlighted. These hold promise enhancing efficacy current treatments warrant further exploration settings.

Language: Английский

Citations

0
Oral Pathogens’ Substantial Burden on Cancer, Cardiovascular Diseases, Alzheimer’s, Diabetes, and Other Systemic Diseases: A Public Health Crisis—A Comprehensive Review DOI Creative Commons
Peter E. Murray, Jonathan Coffman, Franklin García‐Godoy

et al.

Pathogens, Journal Year: 2024, Volume and Issue: 13(12), P. 1084 - 1084

Published: Dec. 9, 2024

This review synthesizes the findings from 252 studies to explore relationship between oral pathogens associated with periodontitis, dental caries, and systemic diseases. Individuals diseases, such as are 1.7 7.5 times (average 3.3 times) more likely develop diseases or suffer adverse pregnancy outcomes, underscoring critical connection overall health. Oral conditions periodontitis caries represent a significant health burden, affecting 26–47% of Americans. The most important pathogens, ranked by publication frequency, include herpes virus, C. albicans, S. mutans, P. gingivalis, F. nucleatum, A. actinomycetemcomitans, intermedia, T. denticola, forsythia. disorders linked infections, similarly, cancer, respiratory, liver, bowel, fever, kidney, complications in pregnancy, cardiovascular bacteremia, diabetes, arthritis, autoimmune, bladder, dementia, lupus, Alzheimer’s Evidence supports efficacy periodontal treatments eliminating infections reducing severity substantial burden that have on Alzheimer’s, other poses public crisis.

Language: Английский

Citations

0
Preclinical in vitro models of HNSCC and their role in drug discovery - an emphasis on the cancer microenvironment and microbiota DOI Creative Commons
Anne‐Sophie Becker, Sonja Oehmcke-Hecht,

Erik Dargel

et al.

Expert Opinion on Drug Discovery, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 21

Published: Dec. 15, 2024

Head and neck squamous cell carcinoma (HNSCC) is the seventh most common cancer worldwide. Treatment options patient outcomes have not improved significantly over past decades, increasing need for better preclinical models. Holistic approaches that include an intact functional immune compartment along with patient's individual tumor microbiome will help improve predictive value of novel drug efficacy.

Language: Английский

Citations

0