Natural Antimicrobial Peptides and Their Synthetic Analogues for Effective Oral Microflora Control and Oral Infection Treatment—The Role of Ceragenins in the Development of New Therapeutic Methods DOI Creative Commons
Michał Czarnowski, Urszula Wnorowska,

Milena Łuckiewicz

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(12), P. 1725 - 1725

Published: Dec. 20, 2024

Oral diseases, both acute and chronic, of infectious or non-infectious etiology, represent some the most serious medical problems in dentistry. Data from literature increasingly indicate that changes oral microbiome, therefore, overgrowing pathological microflora, lead to a variety oral-localized conditions such as caries, gingivitis, periodontitis. In recent years, compelling research has been devoted use natural antimicrobial peptides therapeutic agents possible treatment diseases. This review focuses on potential ceragenins (CSAs), which are lipid analogs peptides, molecules for development new methods prevention Studies date ceragenins, with their spectrum multidirectional biological activities, including antimicrobial, tissue regeneration-stimulating, anti-inflammatory, immunomodulatory properties, strong candidates further formulations. However, many beneficial properties require confirmation experimental reproducing environment fully determine application potential. Their transition practical also requires more advanced testing these clinical trials, have only conducted limited numbers date.

Language: Английский

Construction and Characterization of Polyethylene Glycol/Sodium Alginate Hydrogel Loaded With Zirconia Nanoparticles: Potential Antibacterial and Antibiofilm Agent to Inhibit Dental Caries In Vitro and In Vivo DOI Creative Commons

Layth L. Hamid,

Roqaya S. Zakir,

Nur indah noviyanti Rahman

et al.

Microscopy Research and Technique, Journal Year: 2025, Volume and Issue: unknown

Published: March 21, 2025

Biofilm formation on tooth surfaces is a primary contributor to dental caries and periodontal diseases. Streptococcus mutans recognized for its role in biofilm production, significantly influencing the development of caries. Key virulence factors associated with S. biofilms include acid tolerance, synthesis exopolysaccharides (EPS). This study presents novel approach by focusing loading biosynthesized zirconia nanoparticles (ZrO2 NPs) onto polyethylene glycol/sodium alginate (PEG/SA) hydrogel nanocomposite, evaluating their effects biofilm-forming ability both vivo vitro. ZrO2 NPs were using Citrus aurantifolia (C. aurantifolia) extract incorporated into PEG/SA beads through sol-gel process. The PEG/SA/ZrO2 nanocomposite was confirmed diverse analyzes, including UV-visible spectroscopy, particle size measurement, morphology examination, spectral analysis, thermal gravimetric analysis (TGA) hemolysis studies. average approximately 26 nm, while exhibited highly porous, sheet-like surface structure. In vitro results demonstrated inhibition zones 30 28 mm against mutans, respectively, minimum inhibitory concentration (MIC) 12.5 mg/mL. growth curve indicated complete decline an 87% reduction when treated beads. SEM revealed that cells appeared lysed or crumpled, losing characteristic coccal shape after exposure Additionally, images effective prevention attachment teeth encapsulated hydrogel, altering mature developed treatment. Finally, incorporation hydrogels demonstrates significant potential as strategy inhibiting may serve promising topical agent reducing Further studies could explore long-term efficacy clinical applications this oral health care.

Language: Английский

Citations

0
A scientometric study on research trends and characteristics of halitosis DOI Creative Commons
Xiaole Liu, Ye Zhang, Qingqing Liu

et al.

Journal of Dental Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
In Silico Optimization of a Streptomyces sp. Antimicrobial Peptide Against Oncobacteria in Oral Squamous Cell Carcinoma DOI Open Access
Zarin Taj,

Vannamathi Marisamy,

Indranil Chattopadhyay

et al.

Peptide Science, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 12, 2024

ABSTRACT Oral squamous cell carcinoma (OSCC) is a major public health concern, accounting for more than 90% of all oral malignancies. Pathogenic bacteria, such as Streptococcus mutans , Fusobacterium nucleatum and Porphyromonas gingivalis are closely linked to OSCC promote chronic inflammation, key factor in the tumor microenvironment. The increasing incidence malignancies necessitates development antimicrobial peptides (AMPs) with enhanced anticancer activity targeted therapeutics against bacteria mitigate their impact on OSCC. A total 182 Streptomyces genus‐derived AMPs were collected analyzed silico determine potent antibacterial characteristics. Fourteen tested 3D structural alignment prediction validation, most efficient peptide was determined be sAMP2. genome‐based analysis sourced from globisporus C‐1027 conducted explore its evolutionary significance. cell‐penetrating sAMP2 optimized make it stable better able target host cellular receptors. Mut_sAMP2 found interact bacterial virulence proteins DEX S. LPS F. KGP P. OSCC‐associated (TNFα, IL‐6, IL‐8, p38, p53, E‐cadherin, Jak‐1, PAR2) greater binding affinity. treated OECM‐1 cells showed reduced survival by cytotoxicity IC50 5.4 μg/mL. To best our knowledge, computational study first significantly new effective cancer sp. derived broad spectrum potential evaluating combat progression oncobacteria.

Language: Английский

Citations

0
Natural Antimicrobial Peptides and Their Synthetic Analogues for Effective Oral Microflora Control and Oral Infection Treatment—The Role of Ceragenins in the Development of New Therapeutic Methods DOI Creative Commons
Michał Czarnowski, Urszula Wnorowska,

Milena Łuckiewicz

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(12), P. 1725 - 1725

Published: Dec. 20, 2024

Oral diseases, both acute and chronic, of infectious or non-infectious etiology, represent some the most serious medical problems in dentistry. Data from literature increasingly indicate that changes oral microbiome, therefore, overgrowing pathological microflora, lead to a variety oral-localized conditions such as caries, gingivitis, periodontitis. In recent years, compelling research has been devoted use natural antimicrobial peptides therapeutic agents possible treatment diseases. This review focuses on potential ceragenins (CSAs), which are lipid analogs peptides, molecules for development new methods prevention Studies date ceragenins, with their spectrum multidirectional biological activities, including antimicrobial, tissue regeneration-stimulating, anti-inflammatory, immunomodulatory properties, strong candidates further formulations. However, many beneficial properties require confirmation experimental reproducing environment fully determine application potential. Their transition practical also requires more advanced testing these clinical trials, have only conducted limited numbers date.

Language: Английский

Citations

0