Enhancing the efficacy of Zinc Oxide Nanoparticles by Beta-carotene conjugation for improved anti-microbial and anti-tumor therapy for Dental Application DOI
Mohammed Rafi Shaik, Siva Prasad Panda, Shaik Althaf Hussain

et al.

Pharmaceutical Development and Technology, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 34

Published: Dec. 31, 2024

The increasing prevalence of dental pathogens and oral cancer calls for new therapeutic agents. Nanoparticle (NPs) based tumor therapy enables precise targeting controlled drug release, improving anti-cancer treatment efficacy while reducing systemic toxicity. Zinc oxide NPs (ZnO NPs) are notable in nanomedicine their exceptional physicochemical biological properties. This study synthesizes characterizes beta-carotene-coated ZnO (BT-ZnO potential antimicrobial applications, demonstrating significant against cells. Scanning Electron Microscopy, EDAX, UV, FTIR, XRD, Zeta analysis prepared BT-ZnO revealed uniform flower-like crystalline structures with intricate morphology an average particle size 38.06 nm. FTIR spectra identified various functional groups, suggesting a complex organic compound coated NPs. measurements showed pH-dependent surface charge variations, which crucial understanding colloidal stability. activity was potent pathogens, minimum inhibitory concentration (MIC) values 50 µg/mL highlighting inhibition. Molecular docking studies demonstrated strong binding affinities BT to key receptor proteins pathogens. exhibited antioxidant 68%, comparable ascorbic acid, anti-inflammatory effects 75.1% at 100 µg/mL. Cytotoxicity assays indicated concentration-dependent suppression KB cell proliferation, decreasing viability 37.19%, gene expression elevated P53 expression, apoptotic response. These multifaceted properties underscore the as integrated approach healthcare oncology.

Language: Английский

Production of novel theranostic nano-vector based on superparamagnetic iron oxide nanoparticles/miR-497 targeting colorectal cancer DOI Creative Commons
Asmaa M. Elfiky, May Eid, May A. El‐Manawaty

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 4, 2025

Colorectal cancer (CRC) is a serious public health concern worldwide. Immune checkpoint inhibition medication likely to remain crucial part of CRC clinical management. This study aims create new super paramagnetic iron oxide nano-carrier (SPION) that can effectively transport miRNA specific cell lines. In addition, evaluate the efficiency this nano-formulation as therapeutic candidate for CRC. Bioinformatics tools were used select promising tumor suppressor (mir-497-5p). Green route, using Fusarium oxyporium fungal species, manipulated synthesis SPION@Ag@Cs nanocomposite carrier miR-497-5p. That specifically targets suppression PD1/PDL1 and CTLA4pathways colorectal therapy. UV/visible FTIR spectroscopy, Zeta potential MTT confirm allocation miR-497 on its cytotoxicity against Immunofluorescence was employed transfection cells with miR-497@NPs, down- regulation CTLA4 in HT29, Caco2 On other hand, PDL1 showed significant increase lines (HT-29 Caco-2) response mir497-5p@Nano treatment. The data suggest mir-497 -loaded could be good CTLA4in human Consequently, targeting miR-497/CTLA4 axis immunotherapy treatment strategy

Language: Английский

Citations

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Antibacterial and photocatalytic potential of piperine-derived zinc oxide nanoparticles against multi-drug-resistant non-typhoidal Salmonella spp. DOI Creative Commons
Varsha Unni, Padikkamannil Abishad,

Bibin Mohan

et al.

BMC Microbiology, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 25, 2025

Abstract Background Drug-resistant pathogens and industrial dye wastes have emerged as critical global public health concerns, posing significant risks to human animal health, well environmental sustainability. Green synthesized nano absorbents were found be a viable strategy for treating drug-resistant in wastewater. Hence, this study endeavored the synthesis of piperine-driven nano-zinc oxide (ZnONPs) evaluated them antibacterial, antibiofilm, photocatalytic disinfection potential against multi-drug resistant (MDR) foodborne strains non-typhoidal Salmonella (NTS). Besides, degradation ZnONPs when exposed UV, sunlight, LED lights their antioxidant capacity assessed. Results Initially, silico analysis piperine revealed drug-likeliness with minimal toxicity strong interaction between OmpC motifs spp. UV spectroscopy prominent absorption peak at 340 nm, while PXRD confirmed hexagonal wurtzite structure by exhibiting peaks 30°, 35.6°, 41.3°, 43.6°, 44.3°, 48°, 53°, 58°, 59.2°, which corresponded lattice planes (102), (110), (103), (200), (112), (004), (104), (210), (211). Additionally, TEM images demonstrated predominantly spherical crystalline SAED pattern. The minimum inhibitory concentration bactericidal values (µg/mL) 62.50 125, respectively. observed safe hemolysis (less than 2%) chicken RBCs, no cytopathic effects MTT assay using HEK cell lines. NPs variably stable (high-end temperatures, proteases, cationic salts, diverse pH), tested towards commensal gut lactobacilli. vitro time-kill kinetic indicated that MDR-NTS eliminated after co-incubating 6 h. studies exhibited complete bacterial elimination under visible light 4 Interestingly, significantly inhibited biofilm formation crystal violet staining ( P < 0.001) 24 48 dose-dependent reducing power 2,2′- azinobis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS •+ ) exhibited. Moreover, degraded methylene blue, violet, rhodamine-B different sources (sunlight, light, LED). Conclusions This sustainable one-pot method synthesizing from piperine, might used antibacterial candidate antioxidant, properties eco-friendly implications wastewater treatment.

Language: Английский

Citations

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Dual-action steroid derivatives with anti-inflammatory and antioxidant potency: An in vitro study DOI

Beatrice Di Marco,

Filippo Marchetti, Stefania Costa

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 186, P. 117940 - 117940

Published: March 20, 2025

Language: Английский

Citations

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Synergistic effects of copper oxide-stigmasterol nanoparticles: a novel therapeutic strategy for oral pathogen biofilms and oral cancer DOI Creative Commons
Shaik Althaf Hussain,

Rym Ghimouz,

Siva Prasad Panda

et al.

Materials Technology, Journal Year: 2025, Volume and Issue: 40(1)

Published: March 21, 2025

Oral pathogen biofilms contribute to chronic infections, while oral cancer remains a significant health threat, emphasizing the need for effective therapeutic strategies. This study investigates fabrication, characterization, and potential of copper oxide-stigmasterol nanoparticles (CuO-SS NPs) biofilm disruption treatment. The antimicrobial activity CuO-SS NPs was evaluated against pathogens, including S. aureus, mutans, E. faecalis, C. albicans. In cell studies, exhibited concentration-dependent cytotoxicity, reducing viability from 88% at 15 µg/mL 29.33% 120 µg/mL, comparable doxorubicin (24.3%). significantly upregulated apoptosis markers (Caspase-3, Caspase-8, FasL) by 4.05, 1.4, 3.1 fold, respectively. These results highlight as dual-purpose infections cancer.

Language: Английский

Citations

0
Vine tea (Ampelopsis grossedentata) ameliorates chronic alcohol-induced hepatic steatosis, oxidative stress, and inflammation via YTHDF2/PGC-1α/SIRT3 axis DOI

Qihan Luo,

Jiang Qiu,

Minxia Chen

et al.

Food Research International, Journal Year: 2025, Volume and Issue: unknown, P. 116321 - 116321

Published: March 1, 2025

Language: Английский

Citations

0
Enhanced levofloxacin degradation via peroxodisulfate activation using a magnetic MnFe2O4/pumice catalyst: Mechanisms, toxicity assessment, and degradation pathways DOI
Siyu Yang, Lei Wang,

jianping Qiu

et al.

Journal of Water Process Engineering, Journal Year: 2025, Volume and Issue: 72, P. 107533 - 107533

Published: March 25, 2025

Language: Английский

Citations

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Enhanced photocatalytic performance of CeO2/ZnO/TiO2nanocomposite: Role of reduced bandgap and core-shell heterojunction morphology DOI
S.M. Fathima Khyrun, S.M. Fathima Khyrun, Suresh Sagadevan

et al.

Optical Materials, Journal Year: 2025, Volume and Issue: unknown, P. 116990 - 116990

Published: March 1, 2025

Language: Английский

Citations

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The novel Piperine derivative YL-1-9 exhibits anti-breast Cancer effects by inducing apoptosis via the p53/p21 pathway DOI
Chunxiao Zhou,

Jiayun Wang,

Lili Zhou

et al.

Bioorganic & Medicinal Chemistry Letters, Journal Year: 2025, Volume and Issue: unknown, P. 130231 - 130231

Published: April 1, 2025

Language: Английский

Citations

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Advantageous development of PbS/ZnS nanocomposite photocatalysts from underutilized ionic precursors of solar paints DOI
Imran Majeed, Faizan Raza, Syed Imran Abbas Shah

et al.

Inorganic Chemistry Communications, Journal Year: 2025, Volume and Issue: unknown, P. 114540 - 114540

Published: April 1, 2025

Language: Английский

Citations

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Piperine and its nanoformulations: A mechanistic review of their anti-cancer activities DOI

Mahsa Ghasemi,

M. Hossein Nowroozzadeh, Fereshteh Ghorat

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 187, P. 118075 - 118075

Published: April 23, 2025

Language: Английский

Citations

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