Excessive Weight Gain During Pregnancy Increased Ponoxarase 1 Level in Neonatal Cord Blood
Antioxidants,
Journal Year:
2025,
Volume and Issue:
14(1), P. 105 - 105
Published: Jan. 17, 2025
Maternal
obesity
is
increasingly
recognized
as
a
risk
factor
for
adverse
fetal
outcomes,
primarily
through
its
association
with
heightened
oxidative
stress.
This
study
aimed
to
evaluate
stress
markers
in
umbilical
cord
blood
of
neonates
born
obese
mothers.
Sixty-three
pregnant
women,
who
were
normal
weight
at
the
start
pregnancy
but
classified
term,
included.
Umbilical
samples
collected
immediately
post-delivery
and
analyzed
serum
(total
oxidant
status
(TOS),
total
antioxidant
(TAS),
paraoxanase
(PON),
aryl
esterase,
thiol,
catalase
activities).
Protein
interaction
networks
generated
using
Cytoscape
(v3.10.3),
overlapping
proteins
further
functional
annotations
ShinyGO
(0.80).
The
top
ten
significantly
enriched
pathways
identified
false
discovery
rate
(FDR)
threshold
<0.05.
Significant
associations
found
between
maternal
BMI
change
paraoxonase
1
(PON1)
levels
blood,
while
no
correlation
was
observed
other
status)
status,
catalase).
Additionally,
analysis
showed
significant
relationship
gestational
age,
not
demographic
or
clinical
features.
A
24
common
protein
interactors
associated
PON1,
obesity,
identified.
Functional
annotation
revealed
enrichment
oxidoreductase
activities,
along
involved
insulin
resistance,
AGE-RAGE
signaling,
atherosclerosis.
may
specifically
affect
PON1
activity,
potentially
serving
compensatory
response
neonates,
suggesting
possible
biomarker
stress-related
metabolic
disturbances
mothers,
implications
monitoring
managing
outcomes
populations.
Language: Английский
Expression of Dlx-5 and HLX Proteins in Odontogenic Cysts
Life,
Journal Year:
2025,
Volume and Issue:
15(2), P. 301 - 301
Published: Feb. 14, 2025
Odontogenic
cysts,
commonly
detected
during
routine
examinations
involving
head
and
neck
imaging
such
as
orthopantomograms
computed
tomography
(CT),
are
classified
into
two
groups:
developmental
inflammatory.
Radicular
which
belong
to
the
inflammatory
group,
originate
from
odontogenic
epithelium,
while
dentigerous
cysts
of
origin
observed
a
result
peri-coronal
expansion
fluid
in
dental
follicle.
The
diagnosis
identification
rely
on
clinical,
radiographic,
histological
evaluations.
This
study
aimed
demonstrate
expression
Dlx-5
HLX
proteins
radicular
cysts.
A
total
40
were
obtained
patients
who
visited
private
oral
health
clinics
Bingöl
Diyarbakır
provinces.
After
undergoing
procedures,
stained
using
Masson's
Trichrome
immunohistochemistry
techniques.
As
result,
epithelium
was
found
be
keratinized
stratified
squamous,
with
hyaline
(Rushton)
bodies
located
within
epithelium.
Dentigerous
other
hand,
consisted
non-keratinized
squamous
rete
ridges
hyperplastic
areas,
cell
infiltrations.
immunoreactivity
induced
by
epithelial
connective
tissue
cells
stronger
than
that
HLX.
positive
suggests
these
may
play
potential
role
pathogenesis
Furthermore,
it
considered
might
help
reveal
behavioral
differences
between
Language: Английский
The Impact of Postoperative Albumin Levels on Furosemide Efficacy in Infants with Congenital Heart Disease
Life,
Journal Year:
2024,
Volume and Issue:
14(12), P. 1679 - 1679
Published: Dec. 18, 2024
Postoperative
fluid
overload
is
associated
with
increased
mortality
and
morbidity
in
infants
congenital
heart
disease
(CHD).
Loop
diuretics,
such
as
furosemide,
are
commonly
used
to
prevent
the
postoperative
period.
This
study
aimed
investigate
effect
of
albumin
levels
on
efficacy
furosemide
after
surgery
CHD.
From
1
January
2017
31
December
2022,
levels,
total
doses,
three-day
diuresis
were
retrospectively
analyzed
186
patients
aged
0–1
years
who
underwent
cardiopulmonary
bypass
at
Pediatric
Intensive
Care
Unit,
Diyarbakır
Gazi
Yaşargil
Training
Research
Hospital.
Demographic
clinical
parameters,
along
urine
output
first
6
h,
24
24–48
48–72
h
postoperatively,
recorded.
Patients
divided
into
two
groups
based
their
levels:
normal
(≥30
g/dL)
hypoalbuminemia
(<30
g/dL).
A
common
protein
interaction
network
for
was
constructed
using
Cytoscape
software
(version
3.10.2).
Of
patients,
79
(42.5%)
male
107
(57.5%)
female,
a
median
age
97.5
days
(range
1–360
days).
Furosemide
doses
higher
hypoalbuminemic
2
compared
normoalbuminemic
patients.
On
day
1,
more
prevalent
oliguria,
whereas
normoalbuminemia
significantly
normouria
polyuria.
oliguria
than
those
lower
polyuria
normouria.
positive
correlation
observed
between
2.
Additionally,
existed
postoperatively.
positively
correlated
Mortality
risk
2,
well
Network
analysis
revealed
that
directly
involved
furosemide’s
target
network,
six
other
proteins
within
network.
Diuresis
We
suggest
effectiveness
reduced
because
it
cannot
bind
sufficient
levels.
The
effective
management
may
enhance
improve
outcomes
Language: Английский