How to proceed with easily recrystallizing secnidazole in designing polyelectrolyte complex-based films for periodontitis treatment? DOI Creative Commons
Joanna Potaś, Radosław A. Wach, Karolina Jurkiewicz

et al.

European Journal of Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: 209, P. 107115 - 107115

Published: April 30, 2025

Secnidazole is a second generation 5-nitroimidazole with high potential for application in anaerobic periodontal infections therapy. In this study, the process of developing drug-loaded films composed oppositely charged chitosan and pectin intra-pocket administration presented. Due to limitations layer-by-layer technique receiving systems type, which resulted from spontaneous crystallization secnidazole at stage drying, new preparation method was developed. For purpose, drug cocrystallization as well two-step drying procedure were implemented order minimize crystals growth during solvent evaporation. Through visual assessment, mechanical strength measurements scanning electron microscopy imaging, most promising secnidazole-chitosan cocrystals-loaded selected further physicochemical (via differential calorimetry, Fourier transform infrared spectroscopy, X-ray powder diffraction, optical microscopy) pharmaceutical (in vitro release, antimicrobial swelling tests) analyses. The impact utilized polymeric composition polyelectrolyte complex structures form (crystalline/amorphous) on performance observed. increased temperature enhanced secnidazole-polymers miscibility, desirable loading improvement also significantly prolonged release artificial saliva.

Language: Английский

The Impact of Probiotics on Oral Cancer: Mechanistic Insights and Therapeutic Strategies DOI Creative Commons

Lakshmi Nandhana S S,

D. Maheswary,

Sujith Sri Surya Ravi

et al.

Oral Oncology Reports, Journal Year: 2025, Volume and Issue: unknown, P. 100715 - 100715

Published: Jan. 1, 2025

Language: Английский

Citations

2
How to proceed with easily recrystallizing secnidazole in designing polyelectrolyte complex-based films for periodontitis treatment? DOI Creative Commons
Joanna Potaś, Radosław A. Wach, Karolina Jurkiewicz

et al.

European Journal of Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: 209, P. 107115 - 107115

Published: April 30, 2025

Secnidazole is a second generation 5-nitroimidazole with high potential for application in anaerobic periodontal infections therapy. In this study, the process of developing drug-loaded films composed oppositely charged chitosan and pectin intra-pocket administration presented. Due to limitations layer-by-layer technique receiving systems type, which resulted from spontaneous crystallization secnidazole at stage drying, new preparation method was developed. For purpose, drug cocrystallization as well two-step drying procedure were implemented order minimize crystals growth during solvent evaporation. Through visual assessment, mechanical strength measurements scanning electron microscopy imaging, most promising secnidazole-chitosan cocrystals-loaded selected further physicochemical (via differential calorimetry, Fourier transform infrared spectroscopy, X-ray powder diffraction, optical microscopy) pharmaceutical (in vitro release, antimicrobial swelling tests) analyses. The impact utilized polymeric composition polyelectrolyte complex structures form (crystalline/amorphous) on performance observed. increased temperature enhanced secnidazole-polymers miscibility, desirable loading improvement also significantly prolonged release artificial saliva.

Language: Английский

Citations

0