Radiomics and radiogenomics: extracting more information from medical images for the diagnosis and prognostic prediction of ovarian cancer
Military Medical Research,
Journal Year:
2024,
Volume and Issue:
11(1)
Published: Dec. 14, 2024
Abstract
Ovarian
cancer
(OC)
remains
one
of
the
most
lethal
gynecological
malignancies
globally.
Despite
implementation
various
medical
imaging
approaches
for
OC
screening,
achieving
accurate
differential
diagnosis
ovarian
tumors
continues
to
pose
significant
challenges
due
variability
in
image
performance,
resulting
a
lack
objectivity
that
relies
heavily
on
expertise
professionals.
This
challenge
can
be
addressed
through
emergence
and
advancement
radiomics,
which
enables
high-throughput
extraction
valuable
information
from
conventional
images.
Furthermore,
radiomics
integrate
with
genomics,
novel
approach
termed
radiogenomics,
allows
more
comprehensive,
precise,
personalized
assessment
tumor
biological
features.
In
this
review,
we
present
an
extensive
overview
application
radiogenomics
diagnosing
predicting
tumors.
The
findings
indicate
artificial
intelligence
methods
based
accurately
differentiate
between
benign
malignant
tumors,
as
well
classify
their
subtypes.
Moreover,
these
are
effective
forecasting
survival
rates,
treatment
outcomes,
metastasis
risk,
recurrence
patients
OC.
It
is
anticipated
advancements
will
function
decision-support
tools
managing
while
contributing
precision
medicine.
Language: Английский
Long-term prognostic significance of ascites cytology in ovarian cancer cases in which R0 resection was achieved in the initial surgery: a multi-institutional retrospective cohort study
Japanese Journal of Clinical Oncology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 20, 2025
Abstract
Background
In
ovarian
cancer
(OvCa),
achieving
complete
resection
(RO)
in
initial
surgery
is
crucial
for
improving
prognosis.
However,
patients
with
undetected
microscopic
metastasis
post-RO
often
have
poorer
outcomes.
This
study
explores
prognostic
factors
OvCa
who
underwent
RO
surgery,
focusing
on
the
role
of
ascites
cytology
as
an
indicator
peritoneal
metastasis.
Methods
We
analyzed
data
from
975
cases
Tokai
Ovarian
Tumor
Study
Group
database
(1986–2019).
Excluding
without
chemotherapy
or
distant
metastasis,
we
examined
using
Cox
regression
analysis.
Propensity
score
(PS)
methods
balanced
cytology-positive
and
-negative
groups,
subgroup
analysis
clinical
stage
volume.
Results
Multivariate
identified
FIGO
III
positive
poor
overall
progression-free
survival.
After
PS
adjustment,
also
shortened
intervals
post-recurrence,
especially
lymph
node
Subgroup
revealed
a
more
substantial
impact
early-stage
cases.
Conclusion
The
present
results
suggest
that
R0
status,
presence
tumor
cells
independent
negative
factor
may
be
micro-metastasis.
Language: Английский
Transforming treatment paradigms: Focus on personalized medicine for high‐grade serous ovarian cancer
CA A Cancer Journal for Clinicians,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 19, 2025
Abstract
High‐grade
serous
ovarian
cancer
(HGSOC)
is
the
most
common
and
aggressive
subtype
of
cancer,
accounting
for
approximately
70%
all
cases
contributing
significantly
to
high
mortality
rates
associated
with
this
disease.
Because
asymptomatic
nature
early
stage
disease,
patients
are
diagnosed
at
advanced
stages
when
has
already
spread
into
abdominal
cavity,
requiring
complex
intensive
surgical
chemotherapeutic
interventions
followed
by
maintenance
therapies.
Although
a
minority
well
defined
genetic
syndromes,
specific
risk
factors
clear
etiology
in
many
remain
elusive.
HGSOC
tumors
characterized
frequency
somatic
gene
copy
number
alterations,
often
defects
homologous
recombination
repair
DNA.
All
attempts
introduce
an
effective
screening
date
have
been
unsuccessful.
This
review
elucidates
complexities
surrounding
encompasses
its
etiology,
epidemiology,
classification,
pathogenesis,
current
array
treatment
strategies.
Understanding
molecular
underpinnings
crucial
development
targeted
therapies
personalized
multimodal
approaches
centralized
therapeutic
structures.
also
examines
importance
tumor
microenvironment.
In
addition,
authors'
objective
underscore
critical
placing
patient's
perspective
diversity
forefront
strategies,
thereby
fostering
genuinely
participatory
decision‐making
process
ultimately
improving
patient
quality
life.
Language: Английский
Impact of Intraoperative Blood Transfusions on Survival Rates in Ovarian Cancer Patients
Cancer Control,
Journal Year:
2025,
Volume and Issue:
32
Published: April 1, 2025
Introduction
Ovarian
cancer
remains
a
leading
cause
of
gynecologic
cancer-related
mortality
worldwide.
Identifying
perioperative
factors
that
influence
survival
outcomes
is
essential
for
optimizing
care.
This
study
evaluates
the
impact
such
as
intraoperative
blood
transfusions
and
hospital
length
stay
(LOS)
on
rates
in
ovarian
patients
undergoing
surgical
debulking.
Methods
retrospective
analyzed
charts
314
who
underwent
surgery
at
single
institution
between
2010
2018.
Patients
were
grouped
based
status:
“Live”
or
“Death”.
Variables
included
demographics,
tumor
size,
comorbidity,
anesthesia
time,
estimated
loss,
transfusion,
readmission,
length,
survival.
Statistical
analyses
log-rank
tests
mean
estimations:
chi-square
Mann-Whitney
U-test.
Significance
was
set
P
<
.05.
Results
The
follow-up
50.5
months
(95%
CI,
47.8-53.2).
Prolonged
LOS
(>3
days)
significantly
associated
with
reduced
(47.4
vs
52.4
months,
=
.015).
requiring
had
poorer
(42.0
95%
36.3-47.7
53.1
50.3-55.9,
.001).
“Death”
group
experienced
greater
longer
surgical/anesthesia
times,
higher
fluid
requirements.
Conclusion
stays
are
worse
surgery.
These
findings
underscore
importance
optimization
strategies,
including
minimizing
transfusion
requirements
reducing
through
enhanced
recovery
protocols.
Language: Английский
Overall survival in ovarian cancer patients after cytoreductive surgery. A systematic review and meta-analysis
Qiaoying Chen
No information about this author
Current Problems in Surgery,
Journal Year:
2024,
Volume and Issue:
61(9), P. 101542 - 101542
Published: June 26, 2024
Language: Английский
Current and future trends of acupuncture as an adjuvant therapy in cancer: A bibliometric and visual analysis
Rui Shang,
No information about this author
Ting Pan,
No information about this author
Fengyang Wang
No information about this author
et al.
Medicine,
Journal Year:
2024,
Volume and Issue:
103(29), P. e38663 - e38663
Published: July 19, 2024
Background:
Acupuncture,
as
one
of
the
representatives
complementary
therapies,
is
often
used
an
adjunctive
therapy
in
treatment
cancer
and
related
complications
with
beneficial
results.
Methods:
We
selected
Web
Science
Core
Collection
(WOSCC)
database
data
source
searched
to
obtain
relevant
literatures
on
application
acupuncture
treatment.
The
literature
was
analyzed
using
CiteSpace
(version
6.1.R6)
VOSviewer
1.6.20).
Results:
A
total
592
publications
were
included,
overall
upward
trend
number
publications.
There
135
countries
or
institutions
involved,
China
most
published
country.
1888
institutions,
Memorial
Sloan
Kettering
Cancer
Center
institution
3067
authors
there
obvious
collaborations
between
authors.
190
journals,
J
Clin
Oncol
cited
journal.
frequently
occurring
keywords
breast
management,
but
also
other
topics
such
quality
life,
chemotherapy,
complementary.
Conclusion:
Acupuncture
gaining
increasing
attention
programs.
Currently,
research
focuses
alleviate
cancer-induced
comorbid
symptoms,
pain
insomnia.
Future
gradually
shifting
toward
spiritual
care,
Colorectal
Surgery,
systematic
review.
Language: Английский