Social and obstetric risk factors of antenatal depression: A cross-sectional study in China

World Journal of Psychiatry, Journal Year: 2025, Volume and Issue: 15(4)

Published: March 25, 2025

Antenatal depression is a disabling mental disorder among pregnant women and may cause adverse outcomes for both the mother offspring. Early identification intervention of antenatal can help to prevent outcomes. However, there have been few population-based studies focusing on association social obstetric risk factors with in China. To assess sociodemographic compare network structure depressive symptoms across different levels based large Chinese population. The cross-sectional survey was conducted Shenzhen, China from 2020 2024. assessed using version Edinburgh Postnatal Depression Scale (EPDS), score ≥ 13 indicating presence probable depression. χ 2 test binary logistic regression were used identify associated Network analyses investigate groups levels. Among 44220 women, prevalence 4.4%. An age ≤ 24 years, lower level education (≤ 12 years), low or moderate economic status, having history disorders, being first trimester, primipara, unplanned pregnancy, pregnancy without pre-pregnancy screening found be (all P < 0.05). Depressive symptom networks revealed robust interconnections between symptoms. EPDS8 ("sad miserable") EPDS4 ("anxious worried") showed highest nodal strength This study suggested that Several identified as are pivotal targets clinical alleviate burden high-risk crucial development implementation strategies improve overall quality life women.

Language: Английский

---

Major depression among pregnant women attending a tertiary teaching hospital in Northern Uganda assessed using DSM-V criteria

BMC Pregnancy and Childbirth, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 26, 2025

Abstract Background Major depression (MD) during pregnancy complicates maternal and neonatal outcomes. Despite its significant impact, there is a lack of evidence on the prevalence associated factors MD among pregnant women in Uganda. We assessed magnitude with attending antenatal care (ANC) at large teaching hospital Northern Methods Between June August 2023, we enrolled aged 18 years or older ANC clinic Gulu Regional Referral Hospital Data were collected using validated semi-structured questionnaire. was evaluated DSM-V criteria defined as having (1) least two weeks either persistent low mood excessive sadness, (2) plus additional symptoms from diagnostic criterion A, for total five symptoms, (3) caused distress problem significantly altered behaviour functionality. Modified Poisson regression analyses robust standard errors constructed to evaluate independently major depression. Adjusted ratio (aPR) whose 95% confidence interval (CI) did not include null value (0) p < 0.05 considered statistically significant. Results 329 participants, mean age 26.1± 5.5 years. Overall, 29.8% ( n = 98) had MD; 37 (11.2%) mild, 49 (14.9%) moderate, 12 (3.6%) severe MD. Having co-wife (aPR: 1.64, CI:1.09–2.45, 0.016), an arranged marriage 1.56, CI: 1.02–2.42, 0.042), partner’s income second quartile 2.14, 1.29–3.54, 0.003), experiencing physical violence 1.75, 1.09–3.81, 0.019), controlling behaviours partner 3.60, 1.79–7.26, 0.001), planned 0.53%, 955 0.35–0.81, 0.003) Conclusion Depression affects nearly one-third more prevalent co-wives, marriages, unplanned pregnancies, partners income, who experienced partner. These findings highlight urgent need targeted interventions, including prevention, screening, treatment services within Antenatal Care clinics. Implementing such measures crucial improving maternal, foetal, health outcomes region.

Language: Английский

---

The Potential Protective Role of Ascorbic Acid Against Testicular Toxicity Induced by Fluoxetine in Male Wistar Rats

Journal of Experimental Pharmacology, Journal Year: 2024, Volume and Issue: Volume 16, P. 441 - 453

Published: Nov. 1, 2024

Fluoxetine (FLX) is a Selective Serotonin Re-uptake Inhibitor (SSRI) commonly used as first-line treatment for depression, anxiety, and mood disorders. It can cause infertility in the male reproductive system through release of Reactive Oxygen Species (ROS). This study aimed to evaluate testiculo-protective potential ascorbic acid against fluoxetine-induced spermatotoxicity Wistar rats.

Language: Английский

---

Prevalence and Correlates of Perinatal Depression and Anxiety at Perinatal Clinics in Southwestern Uganda: A Cross-Sectional Study

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 23, 2024

Introduction Depression and anxiety during pregnancy after childbirth are a considerable global public health burden, but data on their magnitude - which is critical for effective intervention limited in Uganda. We investigated the prevalence risk factors perinatal depression among women who visited clinics southwestern Methods From June to August 2022, cross-sectional study was conducted attending at 20 different healthcare facilities Participants were chosen by multi-stage clustered sampling. To screen depression, Edinburgh Postnatal Scale used, while symptoms evaluated using Generalized Anxiety Disorder-7 Scale. Multivariate logistic regression performed identify anxiety. Results A total of 517 participants enrolled. The overall 10.6%, 1.7%. antepartum (APD) postpartum (PPD) 9.9% 10.8%, respectively, (APA) (PPA) 1.0% 3%. Adequate partner support protective against APD (p = 0.036), history stressful situations predicted 0.001). mental illness increased likelihood PPD 0.004). There no statistically significant Conclusion Perinatal highly prevalent primarily associated with psychosocial Thus, screening incorporation social strategies into routine care services may be beneficial.

Language: Английский

---

Prevalence and Determinants of Antenatal Depression Risk Among Urban Women Seeking Antenatal Clinical Care at a District Hospital in Ghana

Nursing Open, Journal Year: 2024, Volume and Issue: 11(12)

Published: Dec. 1, 2024

ABSTRACT Aim To determine the prevalence and factors associated with antenatal depression risk among pregnant women attending care at a district hospital in Kumasi, Ghana. Study Design This was hospital‐based cross‐sectional study. Methods A questionnaire used to collect data from 207 Manhyia District Hospital September 2020 November 2020. The Edinburgh Postnatal Depression Scale screen for risk. Factors were evaluated using logistic regression analysis. Results of 13.5% ( n = 28). most commonly reported intimate partner violence that contributed physical abuse (16.9%, 35). such as (AOR 3.36, 95% CI: 1.13–10.02), domestic 3.88, 1.01–15.00) self‐harm ideation 8.50, 2.44–29.63) increased odds study participants. Conclusion revealed low Extra attention should be given (domestic abuse) ideation. Also, screening all women, especially those factors, early diagnosis treatment are important health mother, fetus newborn.

Language: Английский

---