IOP Conference Series Earth and Environmental Science,
Journal Year:
2024,
Volume and Issue:
1428(1), P. 012012 - 012012
Published: Dec. 1, 2024
Abstract
Oxidative
stress
is
linked
to
various
diseases,
including
cancer
and
cardiovascular
disorders,
due
the
imbalance
between
reactive
oxygen
species
body’s
antioxidant
defenses.
The
use
of
natural
antioxidants
presents
a
sustainable
approach
mitigating
oxidative
damage,
aligning
with
Sustainable
Development
Goals
3
12.
This
study
evaluates
impact
repeated
oral
administration
Terminalia
catappa
aqueous
extract
(AETC)
on
activities
in
Wistar
rats
over
28
days.
enzymatic
non-enzymatic
concentration
endogenous
were
investigated
plasma
tissues
at
end
experiment.
Results
indicated
increased
renal
superoxide
dismutase,
hepatic
peroxidase,
erythrocyte
glutathione-S-transferase
activities.
Hepatic
reduced
glutathione
was
while
malondialdehyde
concentrations
reduced.
These
results
emphasise
AETC’s
tissue-specific
effects
its
potential
as
protective
agent
against
consolidating
ethnobotanical
leaves
tonic
for
health-improving
benefits
promoting
good
health
addition
advocating
ecofriendly
solutions.
Further
elucidatation
AETC
mechanisms
optimisation
therapeutic
applications
required.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Nov. 26, 2024
Nanotechnology
has
been
a
central
focus
of
scientific
investigation
over
the
past
decades
owing
to
its
versatile
applications.
The
synthesis
silver
nanoparticles
(AgNPs)
through
plant
secondary
metabolites
is
cost-effective
and
eco-friendly
approach.
present
study
employed
Brassica
carinata
microgreen
extracts
(BCME)
promote
reduction
nitrate
(AgNO
International Journal of Research in Medical Sciences,
Journal Year:
2025,
Volume and Issue:
13(2), P. 662 - 668
Published: Jan. 30, 2025
Background:
Dyslipidaemia
and
diabetes
mellitus
are
significant
risk
factors
for
cardiometabolic
disease.
This
study
evaluates
the
lipid-lowering
cardioprotective
effects
of
n-hexane
extract
Terminalia
catappa
nuts
(TCN)
in
hyperlipidaemic
hyperglycaemic
Wistar
rats.
Methods:
rats
were
divided
into
two
groups:
negative
control
induced
groups.
The
group
was
further
subdivided
positive
control,
standard
drug-treated,
TCN-treated
groups
with
200,
400,
800
mg/kg/day
six
weeks.
Serum
lipid
profiles
assessed
using
biochemical
methods
after
42
days
treatment
TCN.
Data
analysed
one-way
ANOVA
followed
by
Tukey’s
post-hoc
test
multiple
comparisons,
significance
set
at
p<0.05.
Results:
untreated
exhibited
elevations
total
cholesterol
(TC),
triglycerides
(TG),
low-density
lipoprotein
(LDL)
levels,
alongside
reductions
high-density
(HDL)
levels
(p<0.05).
Treatment
TCN
400
mg/kg
significantly
improved
profiles,
TC,
TG,
LDL
(p<0.001)
an
increase
HDL
compared
to
group.
At
mg/kg,
most
substantial
improvements
observed.
Similarly,
reduced
atherogenic
indices,
including
index
plasma
(AIP),
coefficient
(AC),
Castelli
indices
I
(CRI-I)
II
(CRI-II).
Improvements
dose-dependent,
greatest
doses
(p<0.001).
Conclusions:
demonstrates
conditions,
supporting
its
potential
as
a
natural
therapeutic
managing
cardiovascular
risks
metabolic
syndrome.
International Journal of Secondary Metabolite,
Journal Year:
2025,
Volume and Issue:
12(1), P. 166 - 180
Published: Jan. 19, 2025
The
study
focuses
on
the
five
medicinal
plants
used
by
local
people
residing
in
Calaanan,
Bongabon
Nueva
Ecija
Philippines.
aimed
to
investigate
using
DNA-based
identification,
phytochemical
screening,
and
antioxidant
analysis
of
plant’s
ethanolic
extract.
selected
were
initially
identified
a
taxonomist
molecularly
rbcL
gene
marker.
These
as
Scoparia
dulcis,
Vachellia
fernasiana,
Centella
asiatica,
Sapindus
saponaria,
Ocimum
tenuiflorum.
extracts
underwent
Fourier
Transform
Infrared
spectroscopy
(FTIR)
determine
functional
group
present
each
plant
further
led
Thin
Layer
Chromatography
(TLC)
unveil
presence
absence
secondary
metabolites.
profiles
revealed
essential
oils,
phenols,
fatty
acids,
anthraquinones,
anthrones,
coumarins,
flavonoids,
tannins.
results
from
demonstrated
chemical
diversity
plant,
prompting
investigations
into
its
various
bioactive
properties.
Further,
subjected
2,2'diphenyl-1-1picrylhydrazyl
(DPPH)
radical
scavenging
assay
1000ppm
concentration
crude
extracts,
range
22.71%
79.01%
activity
compared
control
which
is
at
83.56%.
Collectively,
this
reveals
accurate
identity,
profile,
plants.
International Journal of Research in Medical Sciences,
Journal Year:
2025,
Volume and Issue:
13(3), P. 1004 - 1011
Published: Feb. 28, 2025
Background:
Hyperlipidaemia
and
hyperglycaemia
significantly
impair
pancreatic
function
glucose
metabolism,
necessitating
therapeutic
interventions.
This
study
investigated
the
effects
of
n-hexane
extract
Terminalia
catappa
nut
(TCN)
on
homeostasis
histology
in
hyperlipidaemic
hyperglycaemic
Wistar
rats.
Methods:
rats
were
divided
into
six
groups:
negative
control,
positive
standard
drug
control
(atorvastatin
metformin),
TCN-treated
groups
(200,
400,
800
mg/kg).
Fasting
blood
(FBG),
insulin
levels,
HOMA
indices
measured,
tissue
was
histologically
examined.
Data
analysed
using
one-way
ANOVA
followed
by
Tukey's
post-hoc
test
for
multiple
comparisons,
with
significance
set
at
p<0.05.
Results:
TCN
treatment
produced
dose-dependent
improvements
metabolism.
The
mg/kg
group
exhibited
significant
reductions
FBG
(4.56±0.03
mmol/l)
resistance
(HOMA2-IR:
1.30±0.10)
near-normal
levels
(11.85±1.20
μU/ml),
comparable
to
control.
Beta-cell
(HOMA2%B)
improved
progressively
TCN,
dose
achieving
values
similar
(118±4.00).
Histologically,
displayed
intact
islets
Langerhans
organized
acinar
cells.
Conversely,
showed
severe
necrosis,
inflammation,
disrupted
islets.
demonstrated
histological
recovery,
near-complete
restoration
architecture.
Conclusions:
improves
homeostasis,
enhances
beta-cell
function,
restores
integrity
conditions.
These
findings
highlight
potential
as
an
adjunct
managing
metabolic
disorders.
Asian Journal of Chemistry,
Journal Year:
2025,
Volume and Issue:
37(4), P. 758 - 764
Published: March 29, 2025
A
relationship
between
humans
and
nature
began
with
our
ancestral
reliance
on
natural
resources
for
survival
health.
This
has
profoundly
influenced
the
field
of
pharmacology
through
discovery
utilization
product
drugs,
demonstrating
enduring
importance
in
medicine
ongoing
exploration
its
therapeutic
potential.
study
investigates
pharmacological
potential
ethanolic
extract
Ceylon
almond
kernel
(Terminalia
catappa),
highlighting
antioxidant
(IC50
=
21.68
±
1.97
µg/mL),
anti-inflammatory
180.14
3.99
µg/mL)
α-amylase
inhibitory
147.77
4.74
activities.
It
also
showed
antibacterial
activity
against
various
pathogens
minimal
UV
protection
(SPF
5.27
0.63).
These
results
suggest
that
could
be
a
promising
source
pharmaceutical
applications
drug
development.
ABSTRACT
With
the
increasing
concern
over
environmental
pollution
caused
by
synthetic
packaging,
there
is
a
growing
demand
for
sustainable,
biodegradable,
and
functional
materials
in
food
industry.
In
this
study,
antioxidant,
antimicrobial,
physicochemical,
mechanical
properties
of
electrospun
edible
films
based
on
sumac
extract
polyvinyl
alcohol
were
investigated.
The
demonstrated
clear
colorimetric
response
to
pH
changes,
shifting
from
red
acidic
yellow
alkaline
conditions,
making
them
suitable
packaging
freshness
monitoring.
film
containing
30%
(P‐SE
30%)
exhibited
strong
antimicrobial
activity
against
Escherichia
coli
(17.01
mm)
Staphylococcus
aureus
(18.02
mm),
along
with
acceptable
antioxidant
(46.32%).
10%
showed
best
strength
(0.034
MPa).
Moreover,
moisture
content
(4.3%)
water
vapor
permeability
(9.49
g
mm/m
2
Pa)
significantly
reduced.
Also,
physicochemical
(SEM,
FT‐IR,
X‐ray,
thickness,
Opacity,
mechanical)
improved
compared
control
sample.
general,
study
demonstrates
potential
reinforced
as
smart
solution
enhancing
safety.
Asian Journal of Fisheries and Aquatic Research,
Journal Year:
2024,
Volume and Issue:
26(7), P. 67 - 79
Published: July 8, 2024
This
study
aimed
to
evaluate
the
effectiveness
of
Terminalia
catappa
(L)
leaf
flour
extract
in
controlling
Motile
Aeromonas
Septicemia
(MAS)
disease
caused
by
A.
hydrophila
common
carp
larvae.
The
research
method
used
this
is
an
experimental
using
a
complete
randomized
design
(RAL).
consists
2
stages;
vitro
and
vivo
tests
T.
extract.
In
test,
5
different
doses;
treatments
consisted
0
(negative
control),
20,
40,
80,
100
g
L-1
Stroptomycinsulphate
0.005
(positive
control).
3
best
doses
were
selected
based
on
diameter
zone
inhibition;
60,
L-1,
with
positive
(using
untreated
sample
(without
extract),
each
replicates.
results
showed
that
can
significantly
increase
fish's
immune
response,
resistance,
survival.
Duncan's
further
test
dose
treatment
revealed
response
survival
rate
compared
F
G
treatments.
Deleted Journal,
Journal Year:
2024,
Volume and Issue:
7(1)
Published: Dec. 18, 2024
Plants
are
used
in
the
manufacture
of
pharmaceuticals,
cosmetics,
and
food
supplements.
In
this
study,
we
extracted
secondary
metabolites
from
leaves
Ziziphus
robertsoniana
Beentje
using
methanol
water.
The
extracts
were
evaluated
for
their
antimicrobial
properties
by
disk
diffusion
assay,
antioxidant
activities
2,
2-diphenyl-1-picryl-hydrazyl-hydrate
scavenging
activity
ferricyanide
reduction
assay.
functional
groups
compounds
determined
Fourier
transform
infrared
spectroscopy
gas
chromatography-mass
spectroscopy.
screening
revealed
presence
saponins,
tannins,
flavonoids
alkaloids
compounds,
that
linked
to
various
biological
activities.
crude
showed
inhibition
concentration
(IC50)
values
47.88
33.59
µg/ml
aqueous
respectively.
exhibited
dependent
ferric
reducing
power.
Methanolic
extract
had
inhibitory
against
Escherichia
coli,
Pseudomonas
aeruginosa,
Staphylococcus
aures
Bacillus
subtillis
with
zones
between
6
11
mm
as
compared
which
P.
aeruginosa
at
50
100
mg/ml
5.7
8.7
no
any
other
three
bacterial
strains.
Both
effect
on
Candida
albicans
25,
50,
mg/ml.
minimum
ranged
25,000
3125
0.5
0.03125
ciprofloxacin.
These
findings
demonstrate
beneficial
Z.
can
be
formulation
new
products
