Transcutaneous electrical acupoint stimulation for hypertension complicated by anxiety or sleep disorders: a pilot randomized controlled trial

Complementary Therapies in Medicine, Journal Year: 2025, Volume and Issue: 89, P. 103138 - 103138

Published: Jan. 31, 2025

Language: Английский

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Rethinking Depression—Beyond Neurotransmitters: An Integrated Psychoneuroendocrineimmunology Framework for Depression’s Pathophysiology and Tailored Treatment

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2759 - 2759

Published: March 19, 2025

It is known that the effectiveness of drug treatment for depression, ammine deficit based, largely unsatisfactory. In this review, we examine proposal a precision therapy has emerged and received strong push by identification role inflammation in depression. However, psychiatry risks being caught reductionist trap searching molecular switch resets whole system switches off disease. This an illusion since human complex depression systemic variable disorder. study, show inadequacy paradigm, and, at same time, illustrate superiority paradigm centered on psychoneuroendocrineimmunology (PNEI). According to PNEI disease being, caused different sources working together: psychological, biological, behavioral. means knowing biological psychological history subject, identifying relational crisis factors, building personalized treatments targeting those factors with tools medicine psychology, which are not reducible combination drugs psychotherapy. Our presents shift both theoretical practical, enables clinicians assess patients experiencing unified way treat them integrated manner.

Language: Английский

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Treatment of Insomnia With Traditional Chinese Medicine Presents a Promising Prospect

Phytotherapy Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 18, 2025

ABSTRACT Insomnia, a prevalent sleep disorder, significantly impacts global health. While Western medications provide temporary relief, their risks of dependency and cognitive impairment have spurred the search for safer alternatives. Traditional Chinese Medicine (TCM) offers promising approach to treating insomnia by focusing on harmonizing balance Yin Yang functions internal organs. This review explores recent research advances in TCM treatment, integrating classical theories with modern scientific understanding key pathological mechanisms, including neurotransmitter regulation (GABA, monoamines), immune‐inflammatory responses, HPA axis, interactions gut microbiota. Growing clinical evidence supports effectiveness prescriptions treatments like acupuncture improving quality, particularly when combined enhance efficacy reduce dependency. However, also has its limitations. Future directions should focus modernizing applications, addressing comorbidities associated insomnia, exploring role microbiota, optimizing medicinal edible homologous products. By traditional knowledge cutting‐edge technologies, holds great potential advancing personalized effective globally.

Language: Английский

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A surface-based cross-sectional fMRI study on brain function differences between comorbid mild or moderate depression and insomnia

Frontiers in Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: May 13, 2025

Background The mechanisms of Comorbid mild or moderate depression and insomnia (CmiDaI CmoDaI) are complex, stratification remains poorly understood. Methods Resting-state fMRI data were collected from 32 patients with CmiDaI, CmoDaI, 30 healthy controls (HCs). Data analyzed using a surface-based computational method to examine differences in amplitude low-frequency fluctuations (ALFF) functional connectivity (FC) across the brain. Results Significant ALFF found left dorsolateral prefrontal cortex (DLPFC) between CmiDaI CmoDaI. Compared showed increased DLPFC, decreased FC DLPFC right superior temporal gyrus, supramarginal gyrus (SMG) inferior frontal (IFG). Correlation analysis suggests lower correlated more severe insomnia. Lower IFG was associated depression, while SMG Conclusion Our findings suggest that reduced may serve as potential biomarker distinguish offer insights for two disorders’ treatments.

Language: Английский

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The central regulatory effects of acupuncture in treating primary insomnia: a review

Frontiers in Neurology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 10, 2024

Chronic insomnia has the potential to significantly impact physical well-being, occupational performance, and overall quality of life. This review summarizes clinical basic research on central regulatory mechanism acupuncture in treating primary (PI), aiming explore effectiveness possible PI. The currently available drugs for exhibit notable adverse effects tend induce dependence. Empirical evidence from investigations demonstrated that a favorable safety profile while substantially enhancing sleep individuals diagnosed with combination medication been shown augment therapeutic efficacy reducing dosage mitigating occurrence unwanted effects. A current alterations PI patients revealed exerts influence functional activity brain regions implicated cognitive emotional processes. Additionally, found metabolite levels circadian clock gene expression enhance inflammatory responses energy metabolism. Notably, single intervention had modulatory effect similar cumulative acupuncture. trials have limited scale, focused objective. With continuous progress research, extensive randomized controlled high can be combined various neuroimaging technology modalities. Moreover, different targets pathways explored through research. may serve understanding fundamental nervous system mechanisms involved

Language: Английский

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Study Protocol for a Randomized Controlled Trial: Evaluating the Impact of Acupuncture on Menstrual Regulation and Pregnancy Enhancement in Patients with DOR Using Rs-fMRI to Assess Brain Functional Networks

Journal of Multidisciplinary Healthcare, Journal Year: 2024, Volume and Issue: Volume 17, P. 5425 - 5434

Published: Nov. 1, 2024

Resting-state functional magnetic resonance imaging (rs-fMRI) is a noninvasive way to evaluate brain physiological activity by detecting blood oxygen level fluctuations. Diminished ovarian reserve (DOR) indicates aging. Before 40, patients may have menstrual abnormalities, poor reproduction, and assisted reproductive results. Without treatment, it can cause early failure. Studies shown that acupuncture ameliorate sex hormones antral follicle count (AFC) in DOR patients.

Language: Английский

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