Cerebral Blood Flow Changes and Their Spatial Correlations With GABAa and Dopamine‐D1 Receptor Explaining Individual Differences in Chronic Insomnia and the Therapeutic Effects of Acupuncture DOI Creative Commons
Liyong Yu, Lili Yang, Xiaoqin Chen

et al.

Human Brain Mapping, Journal Year: 2025, Volume and Issue: 46(4)

Published: March 1, 2025

ABSTRACT This study integrated neuroimaging and neurochemistry data to explore brain mechanisms in chronic insomnia disorder (CID) the neuromodulatory effects of acupuncture. We analyzed a cross‐sectional arterial spin labeling (ASL) dataset ( N = 197) CID patients healthy controls identify cerebral blood flow (CBF) changes. Additionally, longitudinal ASL 44) examined CBF changes after 4‐week acupuncture treatment or on waitlist. then assessed impact 19 neurotransmitter receptors/transporters these alterations. In comparisons, exhibited increased cortical areas decreased subcortical regions, correlating with severity. enhanced alleviated symptoms, not observed waitlist group. The left putamen was identified as an overlapping region involved both CID‐related post‐treatment Moreover, patterns induced by negatively correlated abnormal patients, were significantly associated GABAa dopamine‐D1 receptor densities. decrease could potentially serve neural biomarker for CID, while may alleviate symptoms increasing this region, through modulation D1 expressions.

Language: Английский

Cerebral Blood Flow Changes and Their Spatial Correlations With GABAa and Dopamine‐D1 Receptor Explaining Individual Differences in Chronic Insomnia and the Therapeutic Effects of Acupuncture DOI Creative Commons
Liyong Yu, Lili Yang, Xiaoqin Chen

et al.

Human Brain Mapping, Journal Year: 2025, Volume and Issue: 46(4)

Published: March 1, 2025

ABSTRACT This study integrated neuroimaging and neurochemistry data to explore brain mechanisms in chronic insomnia disorder (CID) the neuromodulatory effects of acupuncture. We analyzed a cross‐sectional arterial spin labeling (ASL) dataset ( N = 197) CID patients healthy controls identify cerebral blood flow (CBF) changes. Additionally, longitudinal ASL 44) examined CBF changes after 4‐week acupuncture treatment or on waitlist. then assessed impact 19 neurotransmitter receptors/transporters these alterations. In comparisons, exhibited increased cortical areas decreased subcortical regions, correlating with severity. enhanced alleviated symptoms, not observed waitlist group. The left putamen was identified as an overlapping region involved both CID‐related post‐treatment Moreover, patterns induced by negatively correlated abnormal patients, were significantly associated GABAa dopamine‐D1 receptor densities. decrease could potentially serve neural biomarker for CID, while may alleviate symptoms increasing this region, through modulation D1 expressions.

Language: Английский

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