Epigenetic variation in light of population genetic practice

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 25, 2025

The evolutionary impact of epigenetic variation depends on its transgenerational stability and source - whether genetically determined, environmentally induced, or due to spontaneous, genotype-independent mutations. Here, we evaluate current approaches for investigating an independent role epigenetics in evolution, pinpointing methodological challenges. We further identify opportunities arising from integrating data with population genetic analyses natural populations. Efforts advance quality, study design, statistical treatment are encouraged consolidate our understanding the heritable variation, quantify autonomous potential enrich additional layer information.

Language: Английский

Regulatory and evolutionary impact of DNA methylation in two songbird species and their naturally occurring F1 hybrids

BMC Biology, Journal Year: 2024, Volume and Issue: 22(1)

Published: May 28, 2024

Regulation of transcription by DNA methylation in 5'-CpG-3' context is a widespread mechanism allowing differential expression genetically identical cells to persist throughout development. Consequently, differences can reinforce variation gene among cells, tissues, populations, and species. Despite surge studies on methylation, we know little about the importance population differentiation speciation. Here investigate regulatory evolutionary impact five tissues two Ficedula flycatcher species their naturally occurring F

Language: Английский

Generic and Queryable Data Integration Schema for Transcriptomics and Epigenomics studies

Computational and Structural Biotechnology Journal, Journal Year: 2024, Volume and Issue: 23, P. 4232 - 4241

Published: Nov. 19, 2024

Language: Английский