The Crosstalk Between Endothelial Cells, Smooth Muscle Cells, and Macrophages in Atherosclerosis

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(4), P. 1457 - 1457

Published: Feb. 10, 2025

Atherosclerosis (AS) is a chronic inflammatory vascular disease closely tied to cellular metabolism. Recent genome-wide association study data have suggested the significant roles of endothelial cells, smooth muscle and macrophages in regression exacerbation AS. However, impact crosstalk metabolic derangements on progression AS vaguely understood. In this review, we analyze three cell types We also summarize between two them, associated molecules consequences involved. addition, emphasize potential therapeutic targets highlight importance three-cell co-culture model extracellular vesicles AS-related research, providing ideas for future studies.

Language: Английский

P2Y6 Receptor: A Promising Therapeutic Target for Atherosclerosis

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177513 - 177513

Published: March 1, 2025

Language: Английский