Role of Intermittent Fasting In Starving Cancer Cells

Lviv clinical bulletin, Journal Year: 2024, Volume and Issue: 3 (47), P. 96 - 109

Published: Sept. 30, 2024

Introduction. An absolute burden of over 35 million new cancer cases is predicted by 2050. Although significant progress has been made in the field oncology via use surgical removal, radiation treatment, chemotherapy, and introduction immunotherapy, overall rates survival prognoses for patients are still unsatisfactory. In last decade, intermittent fasting (IF) become increasingly popular weight control potential health benefits. Additionally, research primarily focused on investigating impact IF metabolism, mitochondrial function, stress responses, repair mechanisms, autophagy. The aim study. To make a literature review about role starving cells. Materials methods. This narrative involved comprehensive search through databases such as PubMed Google Scholar. Distinct keywords - ″intermittent fasting″, regimens″, ″calorie restriction″, ″oncology″, ″chemotherapy″ ″tumor microenvironment″ were used. Results. exhibits impacts immune system's ability to fight against tumors strengthening hematopoietic stem cells replenish themselves enhance immunosuppression. Under an program, certain tissues organs exhibit enhanced resilience various stressors. Emerging shows that effectiveness tolerance anticancer medicines, regulate carcinogenic influences, reprogram clock genes' rhythmic expression tumor environments, inhibit growth modifying natural processes like insulin signalling, heme oxygenase-1, prevent proliferation myeloid-derived suppressor priming microenvironment support drug delivery targets tumors. Cancer treatment notably shields normal while raising efficacy chemotherapy (CT) reducing CT-induced inflammation several immunological, biochemical, molecular mechanisms. Conclusions. Regularly practising more than one day may confer notable benefits protecting healthy deleterious effects radiation. synergistic therapeutic alongside suggests it enhances also chemotherapy-induced inflammation. While promise cancers, breast cancer, its other types remains uncertain, necessitating further personalized plans.

Language: Английский

Circadian rhythms in haematological malignancies: therapeutic potential and personalised interventions

EBioMedicine, Journal Year: 2024, Volume and Issue: 110, P. 105451 - 105451

Published: Nov. 19, 2024

Language: Английский

Intermittent fasting alters tumor burden, autophagy, and metabolites in chronic lymphocytic leukemia

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

ABSTRACT Emerging preclinical data suggests dietary interventions, including intermittent fasting, may play a key role in altering cancer progression. In feasibility trial monitoring cellular, clinical, and qualitative changes, ten patients with chronic lymphocytic leukemia followed time-restricted eating for three months, five six months. Seven of fifteen participants (47%) experienced decrease or stabilization malignant lymphocyte counts on eating, while accumulation slowed (33%) had no effect (20%). A reduction were accompanied by an unexpected decline cellular autophagy lymphocytes. Metabolite profiling identified microbial-derived bile acid metabolites, glycoursodeoxycholic, taurochenodeoxycholic, glycolithocholic ursodeoxycholic acid, short-chain fatty acids, dehydrolithocholic apocholic that changed eating. Participant quality life improved during These results connect shifts autophagy, tumor progression, life.

Language: Английский