Could Adverse Effects of Antibiotics Due to Their Use/Misuse Be Linked to Some Mechanisms Related to Nonalcoholic Fatty Liver Disease?

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(4), P. 1993 - 1993

Published: Feb. 6, 2024

Nonalcoholic fatty liver disease, recently re-named metabolic dysfunction-associated steatotic is considered the most prevalent disease worldwide. Its molecular initiation events are multiple and not always well-defined, comprising insulin resistance, chronic low-grade inflammation, gut dysbiosis, mitochondrial dysfunction, all of them acting on genetic epigenetic grounds. Nowadays, there a growing public health threat, which antibiotic excessive use misuse. This widespread antibiotics only in humans, but also animals has led to presence residues derived foods, such as milk dairy products. Furthermore, have been used for many decades control certain bacterial diseases high-value fruit vegetables. Recently, it emphasised that antibiotic-induced changes microbial composition reduce diversity alter functional attributes microbiota. These impact human flora, setting motion chain leads straight various alterations can ultimately contribute onset progression NAFLD.

Language: Английский

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The relationship between telomere length and aging-related diseases

Clinical and Experimental Medicine, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 5, 2025

The intensifying global phenomenon of an aging population has spurred a heightened emphasis on studies and disorders associated with aging. Cellular senescence are known to be caused by telomere shortening. Telomere length (TL) emerged as biomarker under intense scrutiny, its widespread use in investigations diseases tied advancing age. This review summarizes the current knowledge association between telomeres aging-related diseases, explores important contribution dysfunctional development progression these aims provide valuable insights for novel therapeutic strategies.

Language: Английский

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Exposure to ambient air pollution and metabolic dysfunction-associated fatty liver disease: Findings from over 2.7 million adults in Northwestern China

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 272, P. 116109 - 116109

Published: Feb. 15, 2024

Ambient air pollutants exposures may lead to aggravated Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD). However, there is still a scarcity of empirical studies that have rigorously estimated this association, especially in regions where pollution severe. To fill the literature gap, we conducted cross-sectional study involving 2711,207 adults living five southern Xinjiang Uyghur Autonomous Region 2021. Using Space-Time Extra-Trees model, assessed four-year (2017–2020) average concentrations particulate matter with aerodynamic diameter ≤1 µm (PM1), ≤2.5 (PM2.5), ≤10 (PM10), ozone (O3), sulfur dioxide (SO2), and carbon monoxide (CO), then assigned these values participants. Generalized linear mixed models were employed examine relationships between prevalence MAFLD, adjustment for multiple confounding factors. The odds ratios 95% confidence intervals MAFLD 2.002 (1.826–2.195), 1.133 (1.108–1.157), 1.034 (1.027–1.040), 1.077 (1.023–1.134), 2.703 (2.322–3.146) 1.033 (1.029–1.036) per 10 µg/m3 increase 4-year PM1, PM2.5, PM10, O3, SO2 CO exposures, respectively. robustness findings was confirmed by series sensitivities. In summary, long-term exposure ambient associated increased particularly males individuals unhealthy lifestyles.

Language: Английский

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The effect of healthy eating index-2015 in the associations of biological aging and non-alcoholic fatty liver disease: an interaction and mediation analysis

Journal of Health Population and Nutrition, Journal Year: 2025, Volume and Issue: 44(1)

Published: Jan. 24, 2025

The present study explored the association between biological aging (BA), healthy eating index-2015 (HEI-2015) and non-alcoholic fatty liver disease (NAFLD) in general population of United States. We used data from NHANES database 2017-2018 years to conduct study. Weighted multivariable logistic regression analysis, restricted cubic spline (RCS), subgroup analysis were performed analyze BA HEI-2015 with prevalence NAFLD mediation effect was also discussed. Additionally, generalized additive model conducted investigate ZJU index, BARD score, fibrosis score. There a total 2,421 individuals. RCS shown that positively correlated NAFLD, while negative risk. After adjusting for interfering factors, compared lowest quartiles HEI-2015, odds ratios 95% confidence intervals across (1.24 (0.84, 1.84), 2.07 (1.15, 3.73) 2.49 (1.16, 5.38)) (0.89 (0.66, 1.18), 0.87 (0.65, 1.16) 0.64 (0.46, 0.87)), respectively. linear positive score However, correlation existed Mediation showed could be mediated weakened by HEI-2015. gradually increases BA, but this can diet.

Language: Английский

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Dynamics of cellular plasticity in non-alcoholic steatohepatitis (NASH)

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2024, Volume and Issue: 1870(4), P. 167102 - 167102

Published: Feb. 28, 2024

Language: Английский

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Accelerometer-derived moderate-to-vigorous physical activity and incident nonalcoholic fatty liver disease

BMC Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Sept. 18, 2024

The liver effects of concentrated vs. more evenly distributed moderate-to-vigorous physical activity (MVPA) patterns remain unclear. We aimed to examine the association accelerometer-measured MVPA and different with outcomes.

Language: Английский

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Physical frailty, genetic predisposition, and the risks of severe non‐alcoholic fatty liver disease and cirrhosis: a cohort study

Journal of Cachexia Sarcopenia and Muscle, Journal Year: 2024, Volume and Issue: 15(4), P. 1491 - 1500

Published: June 18, 2024

Abstract Background Frailty, defined as a phenotype of decreased physiological reserves and diminished ability to respond stressors, has been linked the development chronic diseases. Epidemiological evidence connecting frailty non‐alcoholic fatty liver disease (NAFLD) cirrhosis risks remain sparse. We aimed assess longitudinal associations with severe NAFLD in middle‐aged older adults further explore modification role genetic risk on these associations. Methods This study included total 398 386 participants from UK Biobank. Incident cases were ascertained through hospital records death registries. Frailty status was assessed by modified version phenotype, encompassing five key components: weight loss, tiredness, physical activity, gait speed, grip strength. Participants classified pre‐frailty if they met one or two criteria, three more. Genetic predisposition estimated score (GRS) categorized into high, intermediate, low levels according tertiles GRSs. Cox proportional hazards regression model employed estimate hazard ratios (HRs) 95% confidence intervals (CIs) for their Results The mean (standard deviation) age population 56.6 (8.03) years. 214 408 (53.8%) female; 14 924 (3.75%) criteria frailty, 170 498 (42.8%) pre‐frailty, 212 964 (53.5%) non‐frailty. Over median follow‐up 12.0 years, we documented 4439 incident 3323 cases, respectively. Compared non‐frailty, both (HR: 1.50; CI: 1.40–1.60) 1.98; 1.77–2.21) associated increased NAFLD. Similar observed cirrhosis, corresponding HRs (95% CIs) 1.00 (reference), 1.29 (1.20, 1.38), 1.90 (1.66, 2.18). Such consistent across all levels, no interactions between GRSs (all P ≥0.10). level risk, greatest increasement developing 3.36; 2.83–3.99) 2.81; 2.29–3.44) those high risk. Conclusions Our findings indicate that is significant predictor irrespective predisposition.

Language: Английский

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Leukocyte telomere length decreased the risk of mortality in patients with alcohol-associated liver disease

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 12, 2024

Background It is necessary to find latent indicators predict the survival of alcohol-associated liver disease (ALD) patients. Leukocyte telomere length (LTL) was regarded as an indicator prognosis in several diseases. However, relationships between LTL and well cause-specific mortality ALD patients were still unknown. Objective This study aimed at exploring underlying link risk with ALD. Methods The data gathered from National Health Nutrition Examination Survey (NHANES) 1999–2002. connection assessed by Cox regression models stratified analyses. non-linear relationship explored restricted cubic spline (RCS) analysis. Sensitivity analyses used evaluate robustness our findings. Results a negative factor for all-cause (all p -value < 0.05). cardiovascular (CVD)-related death decreased Q3 ( 0.001) Q4 levels compared Q1 group. Shorter resulted higher cancer-caused = 0.03) Q2 Longer improved especially elder trend or men 0.001). Moreover, there L-shaped correlations non-linearity 0.02), cancer-related Four sensitivity proved Conclusion Our research found that longer CVD mortality. older than 65 years men. might be useful biomarker among More prospective studies are needed assess relevance explore mechanisms them.

Language: Английский

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Accelerated biological aging, genetic susceptibility, and incident severe MASLD, liver cirrhosis and cancer

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: April 10, 2024

Background There is an explicit link between biological age (BA) and chronic liver disease (CLD). This study aimed to explore the association clinical biomarker-based BA potential interaction with genetic risk on incident CLD. Methods prospectively cohort was conducted in UK Biobank included 347,917 participants. We quantified BAs using KDM-BA PhenoAge algorithms constructed polygenic score (PRS) examine its interactions CLD risk. Results first identified acceleration for (KDM-BAaccel) (PhenoAgeAccel) were significantly associated prevalent severe metabolic dysfunction-associated steatotic (MASLD), as well cirrhosis cancer. Each SD increase KDM-BAaccel PhenoAgeAccel correlated 10% elevated of MASLD. Particularly, we observed deleterious effects advanced aging three CLDs males mostly stronger than females. In predicting MASLD, two indicators showed better performance chronological age, AUC values 0.526, 0.571 0.595 PhenoAgeAccel, respectively. Moreover, individuals highest PRS had developing although no significant additive multiplicative found. Additionally, participants who at a high level greatest 10-year absolute reduction MASLD (6.74 per 1000 person-years) if their decreased. Conclusion Our findings elucidate that relieving important preventing serious fatty liver-related diseases could offset adverse inherent

Language: Английский

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Effect of obesity and NAFLD on leukocyte telomere length and hTERT gene MNS16A VNTR variant

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Oct. 23, 2024

It is known that telomere length (TL) (evaluated with T/S ratio) shortened in the presence of obesity. In this study, we aimed to investigate how obesity adolescents and non-alcoholic liver disease (NAFLD) within obese group affect TL clinical significance human telomerase reverse transcriptase (hTERT) gene MNS16A VNTR variant terms NAFLD. Adolescents exogenous healthy controls (aged 10-19 years) who applied our adolescent outpatient clinic between May-October 2023 were included study. We performed upper abdominal ultrasonography NAFLD divided into two groups: those without hepatosteatosis (obese (-)) (+)). recorded body weight, height, waist circumference, blood pressure measurements measured ratio (telomere sequence copy number/gene single number) by Quantitative Polymerase Chain Reaction method. The groups compared using frequentist Bayesian methods. Eighty-three [63 NAFLD(+) 20 NAFLD(-)] 69 lean Pairwise comparisons revealed was significantly lower (-) than (+) control (p = 0.025, p 0.007, respectively). LL allele other alleles 0.022) slightly higher metabolic syndrome 0.072). hTERT-MNS16A-VNTR had a negative correlation among group. Patients ALT, GGT, HOMA-IR, ALT/AST. Diastolic significant ratio. shorter ones but obese. ALT level ALT/AST higher, hTERT adolescents. addition, there diastolic

Language: Английский

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