Effects of Dietary Habits on Markers of Oxidative Stress in Subjects with Hashimoto’s Thyroiditis: Comparison Between the Mediterranean Diet and a Gluten-Free Diet
Nutrients,
Journal Year:
2025,
Volume and Issue:
17(2), P. 363 - 363
Published: Jan. 20, 2025
Background:
The
Mediterranean
diet
(MedD)
exerts
anti-inflammatory
and
anti-oxidant
effects
that
are
beneficial
in
autoimmune
thyroid
diseases
(ATD).
Recently,
a
gluten-free
(GFD)
has
been
proposed
for
non-celiac
patients
with
Hashimoto’s
thyroiditis
(HT),
but
its
usefulness
is
under
debate.
present
pilot
study
evaluates
the
of
these
two
dietary
regimes,
focus
on
redox
homeostasis,
HT.
Patients
Methods:
45
euthyroid
HT
(30
F;
median
age
42
years)
were
randomly
assigned
to
different
regimes:
MedD
(n
=
15),
GFD
15)
free
(FD,
n
15).
Thyroid
function
tests,
autoantibodies,
oxidative
stress
markers
(Advanced
glycation
end
products,
AGEs;
glutathione
peroxidase
(GPx),
thioredoxin
reductase
(TRxR),
total
plasma
antioxidant
activity
(TEAA)
measured
at
baseline
after
12
weeks.
Results:
In
group,
significantly
lower
values
AGEs
higher
GPX,
TRX
TEAA
action
detected
(p
<
0.05)
weeks
compared
baseline,
FD
groups,
which
parameters
did
not
change
>
0.05).
No
significant
differences
serum
levels
TSH,
FT4,
Ab-Tg,
Ab-TPO
found
any
group.
Conclusions:
This
confirms
protective
effect
against
stress,
while
does
influence
and/or
autoimmunity/function
parameters.
Language: Английский
Multi-metal mixture exposure and cognitive function in urban older adults: The mediation effects of thyroid hormones
Zhuoqi Zhu,
No information about this author
Juanhua Li,
No information about this author
Peng Yang
No information about this author
et al.
Ecotoxicology and Environmental Safety,
Journal Year:
2025,
Volume and Issue:
290, P. 117768 - 117768
Published: Jan. 1, 2025
Language: Английский
Serum CD5L Responds Positively to Selenium and Coenzyme Q10 Supplementation with Relation to Thyroid Hormones, Mortality, and Health-Related Quality-of-Life—A Sub-Analysis of a Double-Blind Randomised Placebo-Controlled Trial in Elderly Low in Selenium
Antioxidants,
Journal Year:
2025,
Volume and Issue:
14(3), P. 366 - 366
Published: March 20, 2025
The
Cluster
of
Differentiation
5-like
protein
(CD5L)
is
produced
by
tissue-resident
macrophages.
It
an
innate
immune
mediator
with
a
multitude
functions,
such
as
binding
invading
microorganisms
and
oxidised
LDL,
it
associated
clinical
conditions,
i.e.,
atherosclerosis
inflammation.
circulating
CD5L
level
has
been
reported
to
correlate
selenium
status
thyroid
hormone
activity.
In
order
test
this
hypothesis,
we
analysed
in
serum
samples
from
randomized
controlled
trial
(RCT)
coenzyme
Q10
supplementation
examined
associations
between
hormones,
health-related
quality-of-life
(Hr-QoL),
mortality
elderly
population
low
selenium.
Circulating
levels
hormones
were
determined
359
community-living
individuals
enrolled
RCT
at
inclusion
after
48
months
(179
received
Q10,
180
placebo).
Hr-QoL
was
recorded
both
time-points
using
Short
Form
36.
Pre-intervention
plasma
low,
mean
67
µg/L.
correlated
positively
free
tri-iodothyronine
(fT3)
showed
inverse
relation
stimulating
(TSH).
Low
concentrations
the
placebo
group
increased
cardiovascular
during
10
years
follow-up,
impaired
months.
Selenium
significantly
fT3
levels,
association
better
health
outcome.
data
indicate
that
responds
supplementation,
correlates
status,
associates
positive
indices.
observed
effect
may
be
due
selenium-dependent
deiodinase
isozyme
expression
converts
thyroxine
(T4)
T3
locally
supports
activities.
Whether
are
direct
or
local
activity
unclear
should
further
investigated.
Language: Английский
Circulating Glutathione Peroxidase-3 in Elderly—Association with Renal Function, Cardiovascular Mortality, and Impact of Selenium and Coenzyme Q10 Supplementation
Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(12), P. 1566 - 1566
Published: Dec. 19, 2024
Low-selenium
status
was
associated
with
impaired
renal
function,
which
improved
after
selenium
and
coenzyme
Q10
supplementation
in
an
RCT.
Here,
we
evaluated
serum
glutathione
peroxidase-3
(GPx3)
its
relation
to
selenium,
selenoprotein
P
(SELENOP),
mortality,
the
impact
of
supplementation,
are
all
important,
especially
elderly
individuals.
In
total,
383
study
participants
(197
receiving
yeast
186
on
a
placebo)
were
evaluated.
We
applied
benchmark
dose
modelling
determine
GPx3
saturation,
ANCOVA,
Kaplan–Meier,
multivariate
Cox
proportional
regression
analyses
for
mortality
evaluations.
Selenium
activity
modestly
correlated.
comparison
SELENOP,
levelled
off
at
much
lower
value,
100
vs.
150
µg
Se/L.
but
not
SELENOP.
Supplementation
increased
glomerular
function
by
≈23%
increase
GPx3.
Being
low
displayed
twice
risks
both
placebos
active
treatments.
At
<100
µg/L,
dependent
function.
As
is
reduced
elderly,
appropriate
marker
status.
Low
risk
independent
Language: Английский
A novel frameshift mutation in ADCK1 identified in a case of chronic fatigue syndrome successfully treated with oral 5-ALA/SFC
Immunological Medicine,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 5
Published: Dec. 26, 2024
Chronic
Fatigue
Syndrome
(CFS)
is
a
complex
disorder
characterized
by
prolonged,
unexplained
fatigue
and
challenging
diagnosis.
We
report
the
case
of
35-year-old
Japanese
woman
with
CFS
who
had
experienced
chronic
since
age
11
years.
Despite
treatment
modafinil,
methylphenidate,
levocarnitine,
ubiquinone,
symptoms
persisted.
Introduction
oral
5-aminolevulinic
acid
sodium
ferrous
citrate
(5-ALA/SFC)
led
to
significant
improvements
in
daily
activities,
mobility,
psychosocial
functioning.
Genetic
analysis
revealed
novel
heterozygous
frameshift
deletion
ADCK1
(p.Asn280fs),
gene
related
mitochondrial
function,
which
was
confirmed
using
cDNA
sequencing.
deficiency
has
been
associated
developmental
disabilities,
dysfunction,
increased
reactive
oxygen
species
levels,
apoptosis
Drosophila
muscle
cells.
This
supports
hypothesis
that
mutations
contribute
dysfunction
pathogenesis.
The
patient's
clinical
improvement
5-ALA/SFC
ubiquinone
suggests
their
potential
for
addressing
dysfunction.
Further
functional
familial
analyses
are
required
confirm
role
this
mutation
CFS.
highlights
importance
considering
CFS,
therapeutic
benefits
ubiquinone.
Language: Английский