Maternal Serum and Cord Blood Leptin Concentrations in African Newborns: Relationship to Birth Weight and Gender DOI Open Access
Maria Antonietta Castaldi, Salvatore Giovanni Castaldi, Maurizio Guida

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 515 - 515

Published: Jan. 30, 2025

Background: Leptin, a protein predominantly produced by adipocytes, plays crucial role in regulating energy balance, inflammation, immunity, and fetal growth. During pregnancy, maternal serum leptin levels increase, peaking the second trimester, with placental production contributing to this rise. Leptin has also been identified tissues, its concentration umbilical cord blood correlates birth weight. This study aimed evaluate concentrations rural Burundian women living marginal nutritional conditions, investigate potential gender differences levels. Methods: We analyzed data from 38 healthy singleton pregnancies (20 male 18 female newborns) delivered at Hôpital Autonome de Ngozi, Burundi. were measured samples. Results: Our results revealed that neonatal significantly higher compared newborns, consistent findings other populations. positively correlated weight Kaup index, while did not show such associations. Conclusions: Despite challenging environment African setting, our suggest leptin’s growth regulation may transcend status. The difference observed could be linked genetic or epigenetic factors rather than fat content reproductive hormones. supports notion an important regulator of development, even malnourished populations, underscores need for further research elucidate mechanisms pregnancy.

Language: Английский

Maternal Serum and Cord Blood Leptin Concentrations in African Newborns: Relationship to Birth Weight and Gender DOI Open Access
Maria Antonietta Castaldi, Salvatore Giovanni Castaldi, Maurizio Guida

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 515 - 515

Published: Jan. 30, 2025

Background: Leptin, a protein predominantly produced by adipocytes, plays crucial role in regulating energy balance, inflammation, immunity, and fetal growth. During pregnancy, maternal serum leptin levels increase, peaking the second trimester, with placental production contributing to this rise. Leptin has also been identified tissues, its concentration umbilical cord blood correlates birth weight. This study aimed evaluate concentrations rural Burundian women living marginal nutritional conditions, investigate potential gender differences levels. Methods: We analyzed data from 38 healthy singleton pregnancies (20 male 18 female newborns) delivered at Hôpital Autonome de Ngozi, Burundi. were measured samples. Results: Our results revealed that neonatal significantly higher compared newborns, consistent findings other populations. positively correlated weight Kaup index, while did not show such associations. Conclusions: Despite challenging environment African setting, our suggest leptin’s growth regulation may transcend status. The difference observed could be linked genetic or epigenetic factors rather than fat content reproductive hormones. supports notion an important regulator of development, even malnourished populations, underscores need for further research elucidate mechanisms pregnancy.

Language: Английский

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