Evolving therapeutic strategies for severe fever with thrombocytopenia syndrome: from past to future DOI Creative Commons
Yuxi Zhao, Xiaoxin Wu, Xinyu Wang

et al.

Therapeutic Advances in Infectious Disease, Journal Year: 2025, Volume and Issue: 12

Published: May 1, 2025

Severe fever with thrombocytopenia syndrome (SFTS) is a hemorrhagic caused by Bandavirus dabieense. SFTS was first identified in China 2009 and has been reported since then neighboring countries regions. The clinical manifestations of include fever, thrombocytopenia, leukocytopenia are often accompanied gastrointestinal symptoms bleeding. In severe cases, patients experience life-threatening immune damage cytokine storms. Despite nearly 15 years its discovery, no effective vaccine approved. However, significant progress achieved elucidating the mechanisms host responses, implementation various therapeutic agents. This article provides comprehensive review commonly utilized treatments supported current evidence. Favipiravir advantages over ribavirin terms viral clearance prognosis. Conventional immunomodulators like interferon, intravenous immunoglobulin, glucocorticoids have limited effects may even worsen conditions, whereas novel such as tocilizumab ruxolitinib shown potential for improving Prophylactic platelet transfusions neither prevent bleeding nor improve outcomes. Additionally, plasma exchange, calcium channel blockers, arginine can laboratory values expedite clearance. future, screening Food Drug Administration-approved drugs conducting multiomics analyses lead to discovery new options.

Language: Английский

Ultrasound-assisted metabolite detection in different extraction processes of Bletilla striata and bitter metabolite detection DOI Creative Commons
Juan Zhou, Yu‐Qi Feng, Wenhao Zhou

et al.

Ultrasonics Sonochemistry, Journal Year: 2025, Volume and Issue: 114, P. 107266 - 107266

Published: Feb. 10, 2025

Bletilla striata, a medicinal orchidaceous plant, is recognized for its significant pharmacological value. However, the lack of comparative metabolomic data across different extraction methods analyzing bioactive components has significantly undervalued application potential B. striata in traditional Chinese medicine market. Using six ultrasound-assisted and UPLC-MS/MS, this study identified 1,945 metabolites extracts. The dominant categories were lipids (51.35%), flavonoids (18.00%), phenolic acids (12.51%). KEGG analysis revealed alterations isoflavonoids biosynthesis pathways. Thirteen bitter metabolites, including cinnamic acid, tubers, underscoring their applications, such as anti-inflammatory, antioxidant antibacterial activities. Optimizing can better preserve extracts, thereby enhancing applications food pharmaceutical industries.

Language: Английский

Citations

0
Evolving therapeutic strategies for severe fever with thrombocytopenia syndrome: from past to future DOI Creative Commons
Yuxi Zhao, Xiaoxin Wu, Xinyu Wang

et al.

Therapeutic Advances in Infectious Disease, Journal Year: 2025, Volume and Issue: 12

Published: May 1, 2025

Severe fever with thrombocytopenia syndrome (SFTS) is a hemorrhagic caused by Bandavirus dabieense. SFTS was first identified in China 2009 and has been reported since then neighboring countries regions. The clinical manifestations of include fever, thrombocytopenia, leukocytopenia are often accompanied gastrointestinal symptoms bleeding. In severe cases, patients experience life-threatening immune damage cytokine storms. Despite nearly 15 years its discovery, no effective vaccine approved. However, significant progress achieved elucidating the mechanisms host responses, implementation various therapeutic agents. This article provides comprehensive review commonly utilized treatments supported current evidence. Favipiravir advantages over ribavirin terms viral clearance prognosis. Conventional immunomodulators like interferon, intravenous immunoglobulin, glucocorticoids have limited effects may even worsen conditions, whereas novel such as tocilizumab ruxolitinib shown potential for improving Prophylactic platelet transfusions neither prevent bleeding nor improve outcomes. Additionally, plasma exchange, calcium channel blockers, arginine can laboratory values expedite clearance. future, screening Food Drug Administration-approved drugs conducting multiomics analyses lead to discovery new options.

Language: Английский

Citations

0