Association of combined left and right handgrip strength with new-onset chronic kidney disease in middle-aged and older adults: a nationwide multicenter cohort study DOI Creative Commons
Yu Cao, Alethea Tang, Jinghong Zhao

et al.

BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 13, 2025

The role of multi-site muscle strength in the incidence chronic kidney disease (CKD) remains largely unknown. This study aims to investigate association combined left and right handgrip (CHS) with new-onset CKD middle-aged older adults. observational multicenter included 4618 community-dwelling adults without at baseline 2011. CHS (kg) was assessed participants were followed 2013, 2015, 2018 track incidents. Sex-specific thresholds for low determined using receiver operating characteristic (ROC) analysis. Restricted cubic spline analysis, survival analysis multivariable-adjusted Cox regression models used analyze between CKD. 2526 women 2092 men (median age = 58.87 years). During seven-year follow-up, 503 (10.89%) new cases occurred. associated both (P 0.021) 0.009) a linear-like manner (both P nonlinearity > 0.05). optimal predict incidents 96.15 kg 57.90 women. Kaplan-Meier curves demonstrated that prolonged positively < 0.001) 0.001). Low CHS, defined thresholds, independently an increased risk (HR 1.824, 95% CI 1.379 2.413). relationship strengthened BMI classification normal 2.878, 1.732 4.782, interaction 0.032) baseline, as well those diabetes 2.048, 1.514 2.771, 0.019). longitudinal Chinese These findings highlight potential early-life interventions prevention

Language: Английский

Association of combined left and right handgrip strength with new-onset chronic kidney disease in middle-aged and older adults: a nationwide multicenter cohort study DOI Creative Commons
Yu Cao, Alethea Tang, Jinghong Zhao

et al.

BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 13, 2025

The role of multi-site muscle strength in the incidence chronic kidney disease (CKD) remains largely unknown. This study aims to investigate association combined left and right handgrip (CHS) with new-onset CKD middle-aged older adults. observational multicenter included 4618 community-dwelling adults without at baseline 2011. CHS (kg) was assessed participants were followed 2013, 2015, 2018 track incidents. Sex-specific thresholds for low determined using receiver operating characteristic (ROC) analysis. Restricted cubic spline analysis, survival analysis multivariable-adjusted Cox regression models used analyze between CKD. 2526 women 2092 men (median age = 58.87 years). During seven-year follow-up, 503 (10.89%) new cases occurred. associated both (P 0.021) 0.009) a linear-like manner (both P nonlinearity > 0.05). optimal predict incidents 96.15 kg 57.90 women. Kaplan-Meier curves demonstrated that prolonged positively < 0.001) 0.001). Low CHS, defined thresholds, independently an increased risk (HR 1.824, 95% CI 1.379 2.413). relationship strengthened BMI classification normal 2.878, 1.732 4.782, interaction 0.032) baseline, as well those diabetes 2.048, 1.514 2.771, 0.019). longitudinal Chinese These findings highlight potential early-life interventions prevention

Language: Английский

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