A review on bacteria-derived antioxidant metabolites: their production, purification, characterization, potential applications, and limitations

Archives of Pharmacal Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 10, 2025

Abstract Antioxidants are organic molecules that scavenge reactive oxygen species (ROS) and nitrogen (RNS), thereby maintaining cellular redox balance in living organisms. The human body synthesizes endogenous antioxidants, whereas humans obtain exogenous antioxidants from other organisms such as plants, animals, fungi, bacteria. This review primarily focuses on the antioxidant potential of natural metabolites extracts five major bacterial phyla, including well-studied Actinobacteria Cyanobacteria , well less-studied Bacteroides Firmicutes Proteobacteria . literature survey revealed with activity can be obtained cells their culture supernatants. include pigments, phycobiliproteins, polysaccharides, mycosporins-like amino acids, peptides, phenolic compounds, alkaloids. Both demonstrate vitro capacity through radical-scavenging, metal-reducing, metal-chelating assays. In vivo models, they ROS RNS directly and/or indirectly eliminate them by enhancing activities enzymes, catalase, superoxide dismutase, glutathione peroxidase. Due to activities, may find applications cosmetic industry anti-aging agents for skin medicine drugs or supplements combating oxidative stress-related disorders, neurodegenerative diseases diabetes. also elucidated some exhibited strong antimicrobial properties. Therefore, we consider have future treatment infectious diseases, preparation pathogen-free healthy foods, extension food shelf life.

Language: Английский

Effects of α-sitosterol on growth, hematobiochemical profiles, immune-antioxidant resilience, histopathological features and expression of immune apoptotic genes of Nile tilapia, Oreochromis niloticus, challenged with Candida albicans

Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology, Journal Year: 2024, Volume and Issue: unknown, P. 111035 - 111035

Published: Sept. 1, 2024

Language: Английский

Important antiviral properties of Streptomyces species compounds

Indian Journal of Microbiology Research, Journal Year: 2024, Volume and Issue: 11(1), P. 3 - 7

Published: May 9, 2024

species, a subgroup of Actinomycetes bacteria, have been analysed for their antiviral properties. These bioactive secondary metabolites, which broad spectrum chemical structures and strong biological activity, offer promising opportunity new therapeutics against various viral infections. metabolites target different stages replication or interactions with host cells, making them important research pharmaceutical development. bacteria contain numerous mechanisms that inhibit infections at the life cycle. other actinomycetes can improve health people viruses, recent suggests combining bacterial species could overall regulate This emphasises importance comprehensive approaches to combating into natural products. Further multispecies combinations is needed fully utilise therapeutic potential diseases.

Language: Английский