Integrating Transcriptomics and Genetics to Identify Expression Patterns of RNF144B and FYN as Potential Predictors of Bacterial Meningitis DOI Creative Commons

Hexiang Jiang,

Xibing Yu,

Jingyan Fan

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 6, 2024

Abstract Bacterial meningitis (BM) requires prompt treatment, especially for neonates, the elderly, and immunocompromised individuals. Understanding immune response is essential, as it precedes clinical symptoms. However, systematic studies have been lacking. This study identifies immune-related genes that could enhance BM diagnosis treatment. Mendelian randomization, differential gene expression, co-expression network analyses revealed key linked to BM. RNF144B was identified a risk gene, correlating with increased neutrophil levels during initial phase of meningitis, whereas FYN protective NKT cells remission recovery. Single-cell RNA sequencing set enrichment showed expression in monocytes neutrophils, while associated cells. During onset, there an increase proportions decrease cell proportions, indicating negative correlation. In recovery, decreased, rose, underscoring role may regulate T-cell receptor function cells, reducing risk. suggests patterns these two exhibit significant differences at various stages disease, thus offering potential biomarkers aiding more accurate diagnoses monitoring disease progression.

Language: Английский

Bacterial meningitis is a significant catalyst for neuroinflammation DOI
Sudharsan Parthasarathy, Siva Vijayakumar Tharumasivam,

Ashajyothi Chavaan

et al.

International review of neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Non-coding RNAs in Meningitis: Key Regulators of Immune Response and Inflammation DOI
Mohd Imran,

Abida Abida,

Mehnaz Kamal

et al.

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 263, P. 155626 - 155626

Published: Sept. 27, 2024

Language: Английский

Citations

0
Integrating Transcriptomics and Genetics to Identify Expression Patterns of RNF144B and FYN as Potential Predictors of Bacterial Meningitis DOI Creative Commons

Hexiang Jiang,

Xibing Yu,

Jingyan Fan

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 6, 2024

Abstract Bacterial meningitis (BM) requires prompt treatment, especially for neonates, the elderly, and immunocompromised individuals. Understanding immune response is essential, as it precedes clinical symptoms. However, systematic studies have been lacking. This study identifies immune-related genes that could enhance BM diagnosis treatment. Mendelian randomization, differential gene expression, co-expression network analyses revealed key linked to BM. RNF144B was identified a risk gene, correlating with increased neutrophil levels during initial phase of meningitis, whereas FYN protective NKT cells remission recovery. Single-cell RNA sequencing set enrichment showed expression in monocytes neutrophils, while associated cells. During onset, there an increase proportions decrease cell proportions, indicating negative correlation. In recovery, decreased, rose, underscoring role may regulate T-cell receptor function cells, reducing risk. suggests patterns these two exhibit significant differences at various stages disease, thus offering potential biomarkers aiding more accurate diagnoses monitoring disease progression.

Language: Английский

Citations

0