A Golgi apparatus‑related subtype and risk signature predicts prognosis and evaluates immunotherapy response in gastric cancer DOI Creative Commons

Ruyue Chen,

Zengwu Yao,

Lixin Jiang

et al.

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 22, 2025

Gastric cancer (GC) remains a significant health burden, calling for the discovery of novel biomarkers. Golgi apparatus, crucial cellular organelle involved in tumorigenesis, underexplored GC research. A comprehensive understanding its role and associated mechanisms is urgently needed. Utilizing TCGA-STAD dataset as training cohort GSE84433 validation cohort, we explored potential associations between apparatus-related genes (GARG) clinical risk. We aimed to decipher prognostic significance underlying biological these via consistent clustering, differential expression analysis, enrichment analyses, immune infiltration profiling. To assess relationship risk stratification survival outcomes, drug sensitivity, infiltration, developed Apparatus-Related Risk Signature (GARRS). The reliability GARRS was further corroborated using immunohistochemical staining. Consensus clustering based on 17 GARG identified two patient subgroups, C1 C2, exhibiting survival, scores, cell infiltration. Cox-Lasso regression accurately stratifying patients into high- low-risk groups. GARRS' validity confirmed set Our findings underline apparatus' microenvironment utility predicting outcomes. This study underscores association apparatus subtypes immunotumor microenvironment. GARRS, validated prognostic, sensitivity predictive abilities, offers new insights gastric treatment strategies.

Language: Английский

A Golgi apparatus‑related subtype and risk signature predicts prognosis and evaluates immunotherapy response in gastric cancer DOI Creative Commons

Ruyue Chen,

Zengwu Yao,

Lixin Jiang

et al.

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 22, 2025

Gastric cancer (GC) remains a significant health burden, calling for the discovery of novel biomarkers. Golgi apparatus, crucial cellular organelle involved in tumorigenesis, underexplored GC research. A comprehensive understanding its role and associated mechanisms is urgently needed. Utilizing TCGA-STAD dataset as training cohort GSE84433 validation cohort, we explored potential associations between apparatus-related genes (GARG) clinical risk. We aimed to decipher prognostic significance underlying biological these via consistent clustering, differential expression analysis, enrichment analyses, immune infiltration profiling. To assess relationship risk stratification survival outcomes, drug sensitivity, infiltration, developed Apparatus-Related Risk Signature (GARRS). The reliability GARRS was further corroborated using immunohistochemical staining. Consensus clustering based on 17 GARG identified two patient subgroups, C1 C2, exhibiting survival, scores, cell infiltration. Cox-Lasso regression accurately stratifying patients into high- low-risk groups. GARRS' validity confirmed set Our findings underline apparatus' microenvironment utility predicting outcomes. This study underscores association apparatus subtypes immunotumor microenvironment. GARRS, validated prognostic, sensitivity predictive abilities, offers new insights gastric treatment strategies.

Language: Английский

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