Organ-specific cancer biomarker identification: a ten-year single-center study in southern China DOI Creative Commons
Zhenglin Chang,

Bingsen Chen,

Suilin Wang

et al.

BMC Cancer, Journal Year: 2025, Volume and Issue: 25(1)

Published: May 1, 2025

Cancer biomarker discovery is essential for early detection and monitoring, yet there a lack of comprehensive studies examining organ-specific biomarkers across various cancer types. In this study, we analyzed clinical data from 59,184 patients diagnosed between 2013 2023, focusing on 11 major systems. We used propensity score matching with 55,010 healthy controls to create balanced comparison groups. Serum profiles were assessed through principal component analysis, differential expression ROC curve analysis. Our findings revealed patterns, such as decreased CA724, ferritin, β2-microglobulin in thoracic cancer, reduced serum phosphorus neurological elevated cystatin C creatinine urinary system cancer. Further analysis 22 types uncovered additional biomarkers, including ALT hepatobiliary altered coagulation factors laryngeal increased monocytes pancreatic complement C3 intestinal These results provide valuable insights into the unique signatures different cancers, contributing potential development more targeted efficient screening methods.

Language: Английский

COVID-19 and Disabilities: Impact and the Emergence of Long COVID DOI
Haiyang Li,

Baoqing Sun

Published: Jan. 1, 2025

Language: Английский

Citations

0
Biomarkers for SARS-CoV-2 infection. A narrative review DOI Creative Commons

Sara Weronika Snopkowska Lesniak,

Diego Maschio,

César Henríquez-Camacho

et al.

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: March 26, 2025

COVID-19 is an infectious disease caused by SARS-CoV-2 with devastating effects on health-care systems. The magnitude of the problem has moved physicians and investigators to identify strategies detect patients at a high risk severe disease. aim this study was most relevant biomarkers in published literature their correlation clinical outcomes. To end, we performed revision studies that investigated laboratory abnormalities COVID-19, comparing non-severe patients. Blood were classified into five main categories: hematological, coagulation related liver or kidney, inflammatory. From our analysis, associated infection for each category increased levels leukocytes, neutrophils, neutrophil-to-lymphocyte ratio; decreased platelet count; aspartate transaminase, alanine creatine kinase, troponin, creatinine, blood urea nitrogen, C-reactive protein, ferritin, IL-6. Moreover, lactate dehydrogenase D-dimer independent factors death.

Language: Английский

Citations

0
Ulcerative colitis increases the risk of atrioventricular block: evidence from a Mendelian randomized analysis DOI Creative Commons

Wanqiong Shu,

Guanghong Huang

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 7, 2025

Although inflammatory bowel disease (IBD) has been linked to cardiovascular in a growing body of literature, the relationship between IBD and arrhythmia remains unclear. To investigate causal arrhythmia, we conducted this Mendelian randomization (MR) analysis. We identified single nucleotide polymorphisms (SNP) associated with as instruments, including IBD, ulcerative colitis (UC), Crohn's (CD). SNPs two phenotypes outcome data, namely atrioventricular block (AVB), paroxysmal tachycardia (PTA). The inverse variance weighting method was used analyze two-sample four other methods, MR Egger, Weighted median, Simple mode, mode. Sensitivity analysis involves different methods detect adjust for bias results, heterogeneity analysis, pleiotropy leave-one-out sensitivity ensure rigor selected another set exposure data sets verification using same method. Results suggested UC is significantly an increased risk AVB (odds ratio, OR 1.178, 95% CI 1.070-1.297, P = 0.000828), results are consistent (OR 1.048, 1.007-1.091, 0.022947). Our study suggests potential increase patients UC. These also provide further evidence that may developing arrhythmia.

Language: Английский

Citations

0
Organ-specific cancer biomarker identification: a ten-year single-center study in southern China DOI Creative Commons
Zhenglin Chang,

Bingsen Chen,

Suilin Wang

et al.

BMC Cancer, Journal Year: 2025, Volume and Issue: 25(1)

Published: May 1, 2025

Cancer biomarker discovery is essential for early detection and monitoring, yet there a lack of comprehensive studies examining organ-specific biomarkers across various cancer types. In this study, we analyzed clinical data from 59,184 patients diagnosed between 2013 2023, focusing on 11 major systems. We used propensity score matching with 55,010 healthy controls to create balanced comparison groups. Serum profiles were assessed through principal component analysis, differential expression ROC curve analysis. Our findings revealed patterns, such as decreased CA724, ferritin, β2-microglobulin in thoracic cancer, reduced serum phosphorus neurological elevated cystatin C creatinine urinary system cancer. Further analysis 22 types uncovered additional biomarkers, including ALT hepatobiliary altered coagulation factors laryngeal increased monocytes pancreatic complement C3 intestinal These results provide valuable insights into the unique signatures different cancers, contributing potential development more targeted efficient screening methods.

Language: Английский

Citations

0