Associations of epigenetic age acceleration at birth and age 12 years with adolescent cardiometabolic risk: the HOME study DOI Creative Commons
Jennifer Arzu, Karl T. Kelsey, George D. Papandonatos

et al.

Clinical Epigenetics, Journal Year: 2024, Volume and Issue: 16(1)

Published: Nov. 19, 2024

Abstract Background Cardiometabolic risk factors among youth are rising. Epigenetic age acceleration, a biomarker for aging and disease-risk, has been associated with adiposity in children, but its association other cardiometabolic markers remains understudied. We employed data from the Health Outcomes Measures of Environment (HOME) study, prospective pregnancy birth cohort greater Cincinnati metropolitan area, to examine whether accelerated epigenetic at as well faster pace biological 12 years were higher adolescents. Results After adjusting potential confounders, including estimated cell type proportions, gestational acceleration birth, derived Bohlin, Knight, Haftorn clocks using cord blood DNA methylation data, was not z-scores or individual score components (visceral fat, leptin adiponectin ratio, HOMA-IR, triglycerides HDL-C HbA1c, systolic pressure) years. also did observe any associations calculated Horvath’s skin blood, Hannum’s, Wu’s peripheral years, these same markers. In contrast, [βs (95% CIs)] 0.25 (0.07, 0.42); visceral fat 0.21 (0.05, 0.38); hemoglobin A1c 0.23 0.41) per standard deviation increase aging. Faster positively pressure, although statistically significant. Conclusions Our findings provide evidence that score, HbA1c Further research is needed determine persist adolescence through adulthood.

Language: Английский

Advancing neuroprotection and atherosclerosis prevention through familial hypercholesterolemia management: Analyzing comorbidity burden with stroke, coronary heart disease, hypertension, and diabetes DOI Creative Commons
Jingjia Wang, Sicong Liu, Ming Zhang

et al.

Neuroprotection/Neuroprotection (Chichester, England. Print), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 12, 2025

Abstract Background Despite the World Health Organization's prioritization of familial hypercholesterolemia (FH), its global diagnostic rate remains critically low, leading to inadequate treatment and control, thereby increasing risk atherosclerotic cardiovascular disease. This study aimed investigate comorbidity burden FH in China analyze differences between general (HC) populations. Methods Using a national medical insurance database from 2013 2017 including 13,976 patients with matched control HC, we utilized case‐control methods compare composition ratio, rates, expenses, healthcare those patients. Results The population had higher more than one cardiometabolic disease (83.7% [11,697/13,976]) compared HC group (70.3% [9279/13,976]; χ ² = 250.45, p < 0.0001). rates coronary heart disease, hypertension, stroke, diabetes were (39.2% [5475/13,976], 71.0% [9925/13,976], 14.2% [1982/13,976], 31.2% [4363/13,976], respectively) (30.4% [4255/13,976], 61.4% [8587/13,976], 11.5% [1601/13,976], 28.1% [3923/13,976], respectively; all In 40−49 age group, significantly average number comorbidities (1.2 vs. 0.9; t 15.67, Notably, count aged years even exceeded that 50−59 years. Furthermore, annual per capita cost for was at 5045.5 CNY 4184.7 ( 12.54, Conclusion With large dyslipidemia, type impact burden. presents earlier onset, comorbidities, heavier cardiovascular‐related burdens HC. Early identification, intervention, comprehensive management are crucial neuroprotection prevention

Language: Английский

Citations

0
Depressive symptoms partially mediate the relationship between psychosocial factors and epigenetic age acceleration in a multi-racial/ethnic sample of older adults DOI Creative Commons

Lauren Opsasnick,

Wei Zhao, Lauren Schmitz

et al.

Brain Behavior & Immunity - Health, Journal Year: 2025, Volume and Issue: 45, P. 100994 - 100994

Published: April 13, 2025

Psychosocial factors, including cumulative psychosocial stress and loneliness, have been linked to epigenetic aging in older adults. Further, depressive symptoms established relationships with both factors aging. However, it is not known whether mediate the association between aging.We conducted linear regression models examine associations stress, five age acceleration (AA) measures estimated by DNA methylation a multi-racial/ethnic sample of 2681 adults from Health Retirement Study (mean age: 70.4 years). For all identified associations, we tested for effect modification sex educational attainment performed mediation analysis characterize role on these associations.Psychosocial were each associated at least one measure AA (FDR q < 0.05). observed interactions DunedinPACE, as well loneliness GrimAA, PhenoAA, females individuals without college degree appearing more sensitive effects Depressive mediated 24 % 35 HannumAA, 40 37 GrimAA respectively. this study may help elucidate relationship aging, which critical understanding biological mechanisms through contribute age-related disease.

Language: Английский

Citations

0
Studies on the role of moderate doses of ionizing radiation-induced cellular senescence in mouse lung tissue DOI

Lingyu Zhang,

Lina Cai,

Yashi Cai

et al.

International Journal of Radiation Biology, Journal Year: 2024, Volume and Issue: 100(12), P. 1650 - 1664

Published: Sept. 20, 2024

To investigate the role of moderate doses ionizing radiation-induced cellular senescence in mouse lung tissue and whole-body inflammation levels.

Language: Английский

Citations

1
Cellular and transcriptomic changes by the supplementation of aged rat serum in human pluripotent stem cell-derived myogenic progenitors DOI Creative Commons
Sin-Ruow Tey, Ryan Anderson, Yu Chen

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: Oct. 15, 2024

Introduction The changing composition of non-cell autonomous circulating factors in blood as humans age is believed to play a role muscle mass and strength loss. mechanisms through which these act age-related skeletal changes not fully understood. In this study, we used human myogenic progenitors derived from pluripotent stem cells study roles during the process differentiation. Methods Myogenic embryonic (ESCs) induced (iPSCs) were supplemented with serum samples aged or young Fischer 344 × Brown Norway F1-hybrid rats. effect supplementation on progenitor proliferation, myotube formation capacity, differentiation, early transcriptomic profiles analyzed. Results We found that rat significantly reduced cell proliferation increased death both ESC- iPSC-derived progenitors. Next, inhibited maturation terminal differentiation myocytes when compared treated adult serum. Lastly, identified gene expression affected following culture. Discussion Together, caused cellular current data our vitro model possibly simulate contributions processes muscle.

Language: Английский

Citations

0
Associations of epigenetic age acceleration at birth and age 12 years with adolescent cardiometabolic risk: the HOME study DOI Creative Commons
Jennifer Arzu, Karl T. Kelsey, George D. Papandonatos

et al.

Clinical Epigenetics, Journal Year: 2024, Volume and Issue: 16(1)

Published: Nov. 19, 2024

Abstract Background Cardiometabolic risk factors among youth are rising. Epigenetic age acceleration, a biomarker for aging and disease-risk, has been associated with adiposity in children, but its association other cardiometabolic markers remains understudied. We employed data from the Health Outcomes Measures of Environment (HOME) study, prospective pregnancy birth cohort greater Cincinnati metropolitan area, to examine whether accelerated epigenetic at as well faster pace biological 12 years were higher adolescents. Results After adjusting potential confounders, including estimated cell type proportions, gestational acceleration birth, derived Bohlin, Knight, Haftorn clocks using cord blood DNA methylation data, was not z-scores or individual score components (visceral fat, leptin adiponectin ratio, HOMA-IR, triglycerides HDL-C HbA1c, systolic pressure) years. also did observe any associations calculated Horvath’s skin blood, Hannum’s, Wu’s peripheral years, these same markers. In contrast, [βs (95% CIs)] 0.25 (0.07, 0.42); visceral fat 0.21 (0.05, 0.38); hemoglobin A1c 0.23 0.41) per standard deviation increase aging. Faster positively pressure, although statistically significant. Conclusions Our findings provide evidence that score, HbA1c Further research is needed determine persist adolescence through adulthood.

Language: Английский

Citations

0