Adipokine levels and their association with clinical disease severity in patients with dengue DOI Creative Commons
Heshan Kuruppu, Rivindu Wickramanayake, Chandima Jeewandara

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Jan. 9, 2023

Adipokines have not been studied in acute dengue, despite their emerging role inducing and regulating inflammation. Therefore, we sought to identify adipokine levels patients with varying severities of dengue understand disease pathogenesis. We determined the leptin, resistin, omentin, adiponectin, as well IFNβ, NS1 using quantitative ELISA fever (DF=49) haemorrhagic (DHF=22) at admission (febrile phase) time discharge (recovery phase). The viral loads serotypes all samples were quantified real-time RT-PCR. Resistin (p =0.04) omentin (p=0.006) significantly higher who developed DHF. Omentin febrile phase also correlated AST (Spearman's r=0.38, p=0.001) ALT r=0.24, p=0.04); serum leptin both r=0.27, p=0.02) r=0.28, p=0.02). Serum adiponectin did correlate any other adipokines or liver enzymes, but inversely CRP r=-0.31, p=0.008). Although significant (p=0.14) IFNβ lower those progressed develop DHF (median 0, IQR 0 39.4 pg/ml), compared had DF 37.1, 65.6 pg.ml). data suggest that are likely play a pathogenesis which should be further explored for potential used prognostic markers therapeutic targets.

Language: Английский

Utility and usability of a dengue NS1 rapid diagnostic as a self-test DOI Creative Commons
Nurfatihah Zulkifli,

Naim Che-Kamaruddin,

Anna Hazan

et al.

Tropical Medicine and Health, Journal Year: 2025, Volume and Issue: 53(1)

Published: Feb. 24, 2025

Abstract Background Early detection of dengue fever is pivotal to help differentiate against other febrile illnesses, especially in the dengue-endemic regions. Currently, patients would have go healthcare facility get tested for dengue. A diagnostic approach that empowers persons perform their own tests needed. Here, we evaluated utility and usability NS1 rapid test whether it could be accepted as a home self-test. lateral flow immunochromatography (ICT) using DENV was converted possible self-test kit by providing with device, an alcohol swab, lancet, disposable dropper, assay buffer, manual. Methods Twenty volunteers were recruited this study. The participants performed under observation trained observers who recorded if any procedural error committed. results each interpreted given interpretation table. Results Ninety-five percent (95%) study found instruction manual easy follow 70% felt use. Additionally, 80% successfully obtained expected results. majority (80%) consider needed recommend family members friends. Seventy (70%) participants, most whom monthly income less than USD417, willing pay USD2 kit. Conclusion Findings from suggested highly acceptable and, hence, viable early infection. Trial registration MRECID.NO: 2022628-11345.

Language: Английский

Citations

0
Transmission dynamics of a stochastic model of Chikungunya virus: a case study of Brazil DOI Creative Commons
Milad Fahimi, Kazem Nouri, Leila Torkzadeh

et al.

International Journal of Dynamics and Control, Journal Year: 2025, Volume and Issue: 13(3)

Published: March 1, 2025

Language: Английский

Citations

0
The Impact of Vitamin D in the Prevention of Influenza, COVID-19, and Dengue: A Review DOI Creative Commons
Mario Galindo-Méndez,

Mario Galindo-Ruiz,

María Florencia Concheso-Venegas

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(4), P. 927 - 927

Published: April 9, 2025

Since its discovery, vitamin D (VD) has been known for implications in maintaining bone homeostasis. However, recent years it discovered that the receptor is expressed on different cells of immune system and these can locally produce active form this molecule, calcitriol, strongly suggesting might play a key role both branches system, innate adaptive. Recent evidence demonstrated VD participates protective phases against invading microorganisms, including activation production antimicrobial peptides, inactivation replication infectious agents, prevention exposure cellular receptors to microbial adhesion, and, more importantly, modulation inflammatory response. In years, world witnessed major outbreaks an ancient disease, dengue fever; emergence pandemic caused by unknown virus, SARS-CoV-2; resurgence common respiratory infection, influenza. Despite belonging viral families, etiological agents infections present trait: their capacity cause complications not only through cytopathic effect target tissues but also excessive response produced human host infection. This review outlines current understanding plays aforementioned diseases development participation as modulator

Language: Английский

Citations

0
Adiposity and lean muscle indices that associate with cardiometabolic risk factors and inflammatory mediators in a South Asian population DOI

Dumni Gunasinghe,

Jeewantha Jayamali,

Padukkage Harshani Chathurangika

et al.

Published: May 15, 2025

Abstract Background: Cardiovascular diseases (CVD) are the leading cause of death in South Asia with visceral adiposity and sarcopenic obesity emerging as critical risk factors. Methods: We conducted a cross-sectional study 139 Sri Lankan adults (mean age 39.3, SD ± 10.7, 52 females 87 males) to assess adipose tissue (VAT) area, fat mass index (FMI), ratio (FMR) lean muscle mass, expressed appendicular (ALMI) using dual energy Xray absorptiometry (DEXA). Fasting blood sugar (FBS, lipid profiles, apolipoproteins (A1 B) inflammatory markers (IL-6 IL-1b) were analysed. Results: 23 (44%) 67 (77%) males had VAT area ≥ 100cm2, 34 (65%) 79 (91%) an FMI above cut-off value 30 (58%) females, 33 (38%) FMR value. Females high (≥100cm2) significantly higher levels FBS (p=0.008) lower HDL Apo A1 (p<0.05) compared <100cm2. Further, ≥9 (p=0.01), those 1.2 ApoB ApoA1 levels. There no differences metabolic factors or mediators (≥6) FMR. low ALMI below (<5.5), while 47 (54%) (<7). levels, ApoB/ApoA1 serum cholesterol <7, than normal ALMI. Conclusion: Visceral appear be prevalent Asians gender specific implications. Given marked rise CVD, diabetes related Asia, urgent measures should adopted reduce burden illness due these illnesses associated frailty.

Language: Английский

Citations

0
Soluble Endoglin and Syndecan-1 levels predicts the clinical outcome in COVID-19 patients DOI
Remya Rajan,

Mohamed Hanifah,

Vignesh Mariappan

et al.

Microbial Pathogenesis, Journal Year: 2024, Volume and Issue: 188, P. 106558 - 106558

Published: Jan. 23, 2024

Language: Английский

Citations

2
Are viral loads in the febrile phase a predictive factor of dengue disease severity? DOI Creative Commons

Shashika Dayarathna,

Heshan Kuruppu,

Tehani Silva

et al.

BMC Infectious Diseases, Journal Year: 2024, Volume and Issue: 24(1)

Published: Nov. 5, 2024

Abstract Background As many studies have shown conflicting results regarding the extent of viraemia and clinical disease severity, we sought to investigate if during early dengue illness is associated with subsequent severity. Methods Realtime PCR was carried out identify virus (DENV serotype), in 362 patients, presenting within first 4 days illness, from 2017 2022, Colombo Sri Lanka. To characterize all patients were followed throughout their daily severity classified according WHO 1997 2009 classification. Results 263 had DF, 99 progressed develop DHF, 15/99 DHF developed shock (DSS). Although viral loads higher febrile phase who than DF this not significant ( p = 0.5). Significant differences observed infected different DENV serotypes 0.0009), lowest detected DENV2 highest DENV3. Sub-analysis for association each serotype again significant. those lower loads, infection significantly a risk developing 0.011, Odds ratio 1.9; 95% CI 1.164 3.078). Based on classification, 233 warning signs (DWW), 114 without (DWoWS), 15 severe (SD). No difference between SD, DWW DWoWS 0.27). Conclusions Viral serotypes, do appear associate large Lankan cohort.

Language: Английский

Citations

2
Dengue & COVID-19: A Comparison and the Challenges at Hand DOI Open Access
Deekshitha Alla,

Sai Santhosha Mrudula Alla,

Roopeessh Vempati

et al.

Cureus, Journal Year: 2022, Volume and Issue: unknown

Published: Nov. 25, 2022

The COVID-19 pandemic caused by SARS-CoV-2 spread across many countries between 2020 and 2022. similarities in clinical presentation with other endemic diseases pose a challenge to physicians effectively diagnosing treating the infection. Approximately 129 nations have risk of dengue infection, more than 100 those are dengue. During pandemic, number cases decreased owing isolation measures followed. However, common them has led misdiagnosis. Both fever cause surge pro-inflammatory cytokines chemokines, thus sharing pathophysiology. False positive serological test results also posed difficulty differentiating fever. This review aims compare features, pathophysiology, immune response COVID-19, benefit public health management during pandemic.

Language: Английский

Citations

10
Angiotensin II and dengue DOI
Jesús Mosquera-Sulbarán, Adriana Pedreáñez, Juan Pablo Hernández-Fonseca

et al.

Archives of Virology, Journal Year: 2023, Volume and Issue: 168(7)

Published: June 27, 2023

Language: Английский

Citations

4
Adipokine levels and their association with clinical disease severity in patients with dengue DOI Creative Commons
Heshan Kuruppu, Rivindu Wickramanayake, Chandima Jeewandara

et al.

PLoS neglected tropical diseases, Journal Year: 2023, Volume and Issue: 17(9), P. e0011613 - e0011613

Published: Sept. 7, 2023

Adipokines have not been studied in acute dengue, despite their emerging role inducing and regulating inflammation. Therefore, we sought to identify adipokine levels patients with varying severities of dengue understand disease pathogenesis. We determined the leptin, resistin, omentin, adiponectin, as well IFNβ, NS1 using quantitative ELISA fever (DF = 49) haemorrhagic (DHF 22) at admission (febrile phase) time discharge (recovery phase). The viral loads serotypes all samples were quantified real-time RT-PCR. Resistin (p 0.04) omentin 0.006) significantly higher who developed DHF. Omentin febrile phase also correlated AST (Spearman’s r 0.38, p 0.001) ALT 0.24, 0.04); serum leptin both 0.27, 0.02) 0.28, 0.02). Serum adiponectin did correlate any other adipokines or liver enzymes, but inversely CRP -0.31, 0.008). Although significant 0.14) IFNβ lower those progressed develop DHF (median 0, IQR 0 39.4 pg/ml), compared had DF 37.1, 65.6 pg.ml). data suggest that are likely play a pathogenesis which should be further explored for potential used prognostic markers therapeutic targets.

Language: Английский

Citations

4
Identification of Polyphenol Derivatives as Novel SARS-CoV-2 and DENV Non-Nucleoside RdRp Inhibitors DOI Creative Commons
Shenghua Gao,

Letian Song,

Hongtao Xu

et al.

Molecules, Journal Year: 2022, Volume and Issue: 28(1), P. 160 - 160

Published: Dec. 25, 2022

The Coronavirus Disease 2019 (COVID-19) and dengue fever (DF) pandemics both remain to be significant public health concerns in the foreseeable future. Anti-SARS-CoV-2 drugs vaccines are indispensable eliminate epidemic situation. Here, two piperazine-based polyphenol derivatives DF-47 DF-51 were identified as potential inhibitors directly blocking active site of SARS-CoV-2 DENV RdRp. Data through RdRp inhibition screening an in-house library vitro antiviral study selected effective SARS-CoV-2/DENV polymerase. Moreover, silico simulation revealed stable binding modes between DF-47/DF-51 RdRp, respectively, including chelating with Mg2+ near polymerase site. This work discovered inhibitory effect polyphenols on distinct viral which expected developed into broad-spectrum, non-nucleoside new scaffold.

Language: Английский

Citations

7