Journal of Molecular Medicine, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 6, 2024
Language: Английский
Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)
Published: Nov. 21, 2024
Metabolic alterations, a hallmark of cancer, enable tumor cells to adapt their environment by modulating glucose, lipid, and amino acid metabolism, which fuels rapid growth contributes treatment resistance. In primary breast metabolic shifts such as the Warburg effect enhanced lipid synthesis are closely linked chemotherapy failure. Similarly, metastatic lesions often display distinct profiles that not only sustain but also confer resistance targeted therapies immunotherapies. The review emphasizes two major aspects: mechanisms driving in both how unique environments sites further complicate treatment. By targeting vulnerabilities at stages, new strategies could improve efficacy existing provide better outcomes for cancer patients.
Language: Английский
Citations
16
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 282, P. 137047 - 137047
Published: Nov. 1, 2024
Language: Английский
Citations
5
Technology in Cancer Research & Treatment, Journal Year: 2025, Volume and Issue: 24
Published: March 1, 2025
Breast cancer is one of the leading causes cancer-related deaths in women worldwide. Circular RNAs (circRNAs), a novel class endogenous noncoding RNA with covalently closed continuous loop that lacks 5′-cap structure and 3′-poly A tail, are more stable than linear less susceptible to degradation by nucleases. CircRNAs widespread multiple mammalian genomes have been detected various tissues, cells body fluids. Increasing evidence shows abnormal expression circRNAs involved development variety diseases, including breast cancer. Numerous studies explored potential as biomarkers malignant tumors. In this review, we aim provide comprehensive overview latest advances promising early diagnosis, prognosis, molecular type, metastasis drug resistance
Language: Английский
Citations
0
Phytotherapy Research, Journal Year: 2025, Volume and Issue: unknown
Published: March 29, 2025
Non-coding RNAs (ncRNAs) are a distinctive class of RNA transcripts that have received extensive attention from the global scientific community due to their intricate and important roles in tumor malignancy. The dysregulated expression ncRNAs is closely associated with progression different types cancer, suggesting serve as key regulatory factors modulate numerous cancer biomarkers. complex interactions between ncRNAs, including microRNAs (miRNAs), long non-coding (lncRNAs), circular (circRNAs), well mRNAs or RNA-binding proteins, orchestrate many biological processes tumors. Natural products, obtained dietary medicinal sources, extremely safe stable therapeutic outcomes. These products can regulate effectively inhibiting cell growth proliferation even triggering death. This ability highlights they reduce burden enhance clinical outcomes for patients. In this review we discussed mechanisms underlying ncRNAs-mediated regulation systematically highlighted diverse antitumor applications natural specifically control ncRNAs. We aimed provide novel perspectives methods field anticancer research, focusing on application products.
Language: Английский
Citations
0
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 3982 - 3982
Published: April 3, 2024
Deregulation of small non-coding RNAs (sncRNAs) has been associated with the onset metastasis. We evaluated expression sncRNAs in patients early-stage breast cancer, performing RNA sequencing 60 for whom tumor and sentinel lymph node (SLN) samples were available, conducting differential expression, gene ontology, enrichment survival analyses. Sequencing annotation classified most into nucleolar (snoRNAs, 70%) nuclear (snRNA, 13%). Our results showed no significant differences sncRNA between or SLNs obtained from same patient. Differential analysis down-regulation (n = 21) up-regulation 2) locoregional The SNHG5, SNORD90, SCARNA2 SNORD78 differentiated luminal A B tumors, whereas SNORD124 was HER2+ tumors. Discriminating receiver-operating curve revealed a signature six snoRNAs (SNORD93, SNORA16A, SNORD113-6, SNORA7A, SNORA57 SNORA18A) that distinguished metastasis predicted patient outcome. Gene ontology Reactome pathway an biological processes translation initiation, protein targeting to specific cell locations, positive regulation Wnt NOTCH signaling pathways, commonly involved promotion metastases. point potential several as surrogate markers metastases outcome cancer patients. Further preclinical clinical studies are required understand significance validate our larger cohort
Language: Английский
Citations
2
Gene Reports, Journal Year: 2024, Volume and Issue: 36, P. 101973 - 101973
Published: July 14, 2024
Language: Английский
Citations
2
Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14
Published: Oct. 1, 2024
Breast cancer (BC) is a prevalent malignant tumor in women, and its incidence has been steadily increasing recent years. Compared with other types of cancer, it the highest mortality morbidity rates women. So, crucial to investigate underlying mechanisms BC development identify specific therapeutic targets. Pyruvate kinase M2 (PKM2), an important metabolic enzyme glycolysis, found be highly expressed BC. It can also move nucleus interact various transcription factors proteins, including hypoxia-inducible factor-1α (HIF-1α), signal transducer activator 3 (STAT3), β-catenin, cellular-myelocytomatosis oncogene (c-Myc), nuclear factor kappa-light-chain enhancer activated B cells (NF-κB), mammalian sterile 20-like 1 (MST1). This interaction leads non-metabolic functions that control cell cycle, proliferation, apoptosis, migration, invasion, angiogenesis, microenvironment review provides overview latest advancements understanding interactions between PKM2 different proteins influence initiation progression examined how natural drugs noncoding RNAs affect biological processes through regulation PKM2. The findings provide valuable insights for improving prognosis developing targeted therapies coming
Language: Английский
Citations
2
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, Journal Year: 2024, Volume and Issue: unknown, P. 195061 - 195061
Published: Sept. 1, 2024
Language: Английский
Citations
1
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(10), P. 5142 - 5142
Published: May 9, 2024
Chondrosarcoma is a malignant bone tumor that arises from abnormalities in cartilaginous tissue and associated with lung metastases. Lymphangiogenesis plays an essential role cancer metastasis. Visfatin adipokine reported to enhance metastasis, but its relationship VEGF-D generation lymphangiogenesis chondrosarcoma remains undetermined. Our results clinical samples reveal levels are markedly higher patients than normal individuals. stimulation promotes VEGF-D-dependent lymphatic endothelial cell lymphangiogenesis. We also found visfatin induces production by activating HIF-1α reducing miR-2277-3p through the Raf/MEK/ERK signaling cascade. Importantly, controls chondrosarcoma-related vivo. Therefore, promising target treatment of
Language: Английский
Citations
0
Journal of Molecular Medicine, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 6, 2024
Language: Английский
Citations
0