Cordycepin combined with antioxidant effects improves fatigue caused by excessive exercise

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 9, 2025

Excessive exercise can lead to physical fatigue and disruption of the antioxidant system, resulting in neurological damage cognitive decline. Cordycepin, main component Cordyceps militaris, has anti-inflammatory, neuroprotective effects. In this study, anti-fatigue effect potential mechanism action cordycepin were investigated using a forced mouse model. The results showed that oral administration enhanced endurance, increased liver muscle glycogen content, simultaneously decreased serum levels lactic acid, lactate dehydrogenase, creatine kinase, blood urea nitrogen (p < 0.05). addition, had effects, increasing superoxide dismutase activity decreasing malondialdehyde (MDA) 0.01). vitro experiments further demonstrated effects cordycepin. Behavioral tests learning memory ability mice excessive model group 40% compared with control group. Cordycepin alleviated deficits over-exercised mice, significantly reduced metabolites oxidative stress vivo 0.05), altered neurotransmitters Furthermore, modulated Keap1/Nrf2/HO-1-mediated BDNF These findings suggest alleviate exercise-induced by modulating Keap1/Nrf2/HO-1 signaling pathway expression, providing strong supporting evidence for development cordycepin-functional foods or drugs.

Language: Английский

Luteolin protects mouse hippocampal neuronal cells against isoflurane-induced neurotoxicity through miR-214/PTEN/Akt pathway

NeuroToxicology, Journal Year: 2024, Volume and Issue: 103, P. 310 - 319

Published: July 1, 2024

Language: Английский