The role of the CCL5-CCR5 Axis in microglial activation leading to postoperative cognitive dysfunction DOI Creative Commons
Yuanyuan An, Yao Yu, Huan Liu

et al.

Experimental Neurology, Journal Year: 2024, Volume and Issue: 385, P. 115114 - 115114

Published: Dec. 10, 2024

Postoperative cognitive dysfunction (POCD) is a common complication following surgeries involving general anesthesia. Although the CCL5-CCR5 axis implicated in various neurological conditions, its role POCD remains unclear. In our model, we observed an increase CCL5 and CCR5 levels concurrent with microglial activation significant upregulation of inflammatory cytokines IL-6 IL-1β. Administration MVC, antagonist, alleviated neuroinflammation, prevented dendritic spine loss, improved deficits by inhibiting CCR5/CREB/NLRP1 pathway. However, benefits MVC were reversed CREB inhibitor 666-15. Our findings highlight potential targeting as therapeutic strategy for preventing treating POCD.

Language: Английский

Olfactory mucosa-mesenchymal stem cells with overexpressed Nrf2 modulate angiogenesis and exert anti-inflammation effect in an in vitro traumatic brain injury model DOI Creative Commons
Zigui Chen, Chunyuan Zhang,

Yuhua Fang

et al.

European journal of medical research, Journal Year: 2025, Volume and Issue: 30(1)

Published: Feb. 5, 2025

Language: Английский

Citations

0
In silico discovery of novel compounds for FAK activation using virtual screening, AI-based prediction, and molecular dynamics DOI

D. Y. Yoon,

Hyunsu Lee

Computational Biology and Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 108420 - 108420

Published: March 1, 2025

Language: Английский

Citations

0
The role of the CCL5-CCR5 Axis in microglial activation leading to postoperative cognitive dysfunction DOI Creative Commons
Yuanyuan An, Yao Yu, Huan Liu

et al.

Experimental Neurology, Journal Year: 2024, Volume and Issue: 385, P. 115114 - 115114

Published: Dec. 10, 2024

Postoperative cognitive dysfunction (POCD) is a common complication following surgeries involving general anesthesia. Although the CCL5-CCR5 axis implicated in various neurological conditions, its role POCD remains unclear. In our model, we observed an increase CCL5 and CCR5 levels concurrent with microglial activation significant upregulation of inflammatory cytokines IL-6 IL-1β. Administration MVC, antagonist, alleviated neuroinflammation, prevented dendritic spine loss, improved deficits by inhibiting CCR5/CREB/NLRP1 pathway. However, benefits MVC were reversed CREB inhibitor 666-15. Our findings highlight potential targeting as therapeutic strategy for preventing treating POCD.

Language: Английский

Citations

2