Olfactory mucosa-mesenchymal stem cells with overexpressed Nrf2 modulate angiogenesis and exert anti-inflammation effect in an in vitro traumatic brain injury model
Zigui Chen,
No information about this author
Chunyuan Zhang,
No information about this author
Yuhua Fang
No information about this author
et al.
European journal of medical research,
Journal Year:
2025,
Volume and Issue:
30(1)
Published: Feb. 5, 2025
Language: Английский
In silico discovery of novel compounds for FAK activation using virtual screening, AI-based prediction, and molecular dynamics
D. Y. Yoon,
No information about this author
Hyunsu Lee
No information about this author
Computational Biology and Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown, P. 108420 - 108420
Published: March 1, 2025
Language: Английский
The role of the CCL5-CCR5 Axis in microglial activation leading to postoperative cognitive dysfunction
Yuanyuan An,
No information about this author
Yao Yu,
No information about this author
Huan Liu
No information about this author
et al.
Experimental Neurology,
Journal Year:
2024,
Volume and Issue:
385, P. 115114 - 115114
Published: Dec. 10, 2024
Postoperative
cognitive
dysfunction
(POCD)
is
a
common
complication
following
surgeries
involving
general
anesthesia.
Although
the
CCL5-CCR5
axis
implicated
in
various
neurological
conditions,
its
role
POCD
remains
unclear.
In
our
model,
we
observed
an
increase
CCL5
and
CCR5
levels
concurrent
with
microglial
activation
significant
upregulation
of
inflammatory
cytokines
IL-6
IL-1β.
Administration
MVC,
antagonist,
alleviated
neuroinflammation,
prevented
dendritic
spine
loss,
improved
deficits
by
inhibiting
CCR5/CREB/NLRP1
pathway.
However,
benefits
MVC
were
reversed
CREB
inhibitor
666-15.
Our
findings
highlight
potential
targeting
as
therapeutic
strategy
for
preventing
treating
POCD.
Language: Английский