Customized Hydrogel System for the Spatiotemporal Sequential Treatment of Periodontitis Propelled by ZEB1 DOI Creative Commons
Jiafei Chen, Xiaoxu Guan, Lina Chen

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 4, 2025

Abstract Advanced periodontitis initiates with Porphyromonas gingivalis ( P. ) infection, which subsequently triggers chronic inflammation, immune imbalance, and ultimately causes alveolar bone resorption. Traditional periodontal treatment focuses on the elimination of triggering factors, but tend to ignore improvement inflammatory microenvironment remodeling osteogenic mineralization space. Herein, zinc‐aluminum layered double hydroxide nanosheets (LDHs) loaded icariin (ICA) are encapsulated into a gallic acid (GA)‐modified hydroxybutyl chitosan hydrogel (GA‐HBC), giving rise customized system named GA‐HBC‐LIC, can sequentially actualize antibacterial, anti‐inflammatory, remineralization functions. A neutral chemical‐humoral space is created for osteogenesis via means sequential regulation by smart hydrogel. Concomitantly, appropriate mechanical properties degradation performance provide desirable physical remineralization. In spatiotemporal modulation hydrogel, zinc finger E‐box‐binding homeobox 1 (ZEB1) target released ions (Zn 2+ action promotes macrophage polarization from M1 M2 phenotype, thereby releasing cytokines conducive tissue regeneration. sum, this study highlights critical role inflammation maintenance in regeneration tissues, offering new insights clinical management periodontitis.

Language: Английский

miR-200 Family: Gatekeepers of Fibrinolytic Regulation in Lung Pathologies during Acute Lung injury DOI

T M Jeena,

C Rakshitha,

Fathimath Muneesa

et al.

Archives of Biochemistry and Biophysics, Journal Year: 2025, Volume and Issue: unknown, P. 110398 - 110398

Published: March 1, 2025

Language: Английский

Citations

0
Liraglutide Attenuates High Glucose-Induced Endothelial Cell Senescence and Dysfunction via SIRT1-Mediated Deacetylation of p53/p65 DOI

Weili Zhong,

Ying Yang, Wang Yanru

et al.

Tissue and Cell, Journal Year: 2025, Volume and Issue: unknown, P. 102882 - 102882

Published: April 1, 2025

Language: Английский

Citations

0
Customized Hydrogel System for the Spatiotemporal Sequential Treatment of Periodontitis Propelled by ZEB1 DOI Creative Commons
Jiafei Chen, Xiaoxu Guan, Lina Chen

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 4, 2025

Abstract Advanced periodontitis initiates with Porphyromonas gingivalis ( P. ) infection, which subsequently triggers chronic inflammation, immune imbalance, and ultimately causes alveolar bone resorption. Traditional periodontal treatment focuses on the elimination of triggering factors, but tend to ignore improvement inflammatory microenvironment remodeling osteogenic mineralization space. Herein, zinc‐aluminum layered double hydroxide nanosheets (LDHs) loaded icariin (ICA) are encapsulated into a gallic acid (GA)‐modified hydroxybutyl chitosan hydrogel (GA‐HBC), giving rise customized system named GA‐HBC‐LIC, can sequentially actualize antibacterial, anti‐inflammatory, remineralization functions. A neutral chemical‐humoral space is created for osteogenesis via means sequential regulation by smart hydrogel. Concomitantly, appropriate mechanical properties degradation performance provide desirable physical remineralization. In spatiotemporal modulation hydrogel, zinc finger E‐box‐binding homeobox 1 (ZEB1) target released ions (Zn 2+ action promotes macrophage polarization from M1 M2 phenotype, thereby releasing cytokines conducive tissue regeneration. sum, this study highlights critical role inflammation maintenance in regeneration tissues, offering new insights clinical management periodontitis.

Language: Английский

Citations

0