Journal of Clinical Investigation,
Journal Year:
2023,
Volume and Issue:
133(16)
Published: Aug. 14, 2023
The
pulmonary
vasculature
has
been
frequently
overlooked
in
acute
and
chronic
lung
diseases,
such
as
respiratory
distress
syndrome
(ARDS),
fibrosis
(PF),
obstructive
disease
(COPD).
primary
emphasis
the
management
of
these
parenchymal
disorders
largely
revolved
around
injury
aberrant
repair
epithelial
cells.
However,
there
is
increasing
evidence
that
vascular
endothelium
plays
an
active
role
development
diseases.
endothelial
cell
network
capillary
bed
arterial
venous
vessels
provides
a
metabolically
highly
barrier
controls
migration
immune
cells,
regulates
tone
permeability,
participates
remodeling
processes.
Phenotypically
functionally
altered
remodeled
vessels,
can
be
found
although
to
different
degrees,
likely
because
disease-specific
mechanisms.
Since
associated
with
hypertension,
which
worsens
patient
outcomes
survival,
it
crucial
understand
underlying
alterations.
In
this
Review,
we
describe
current
knowledge
regarding
progression
ARDS,
PF,
COPD;
also
outline
future
research
directions
hope
facilitating
mechanism-based
therapies.
Biochemical Journal,
Journal Year:
2023,
Volume and Issue:
480(23), P. 1987 - 2008
Published: Dec. 6, 2023
Interleukin
11
(IL11)
is
an
elusive
member
of
the
IL6
family
cytokines.
While
initially
thought
to
be
a
haematopoietic
and
cytoprotective
factor,
more
recent
data
show
instead
that
IL11
redundant
for
haematopoiesis
toxic.
In
this
review,
reasons
led
original
misunderstandings
biology,
which
are
now
understandable,
explained
with
particular
attention
on
use
recombinant
human
in
mice
humans.
Following
tissue
injury,
as
part
evolutionary
ancient
homeostatic
response,
secreted
from
damaged
mammalian
cells
signal
via
JAK/STAT3,
ERK/P90RSK,
LKB1/mTOR
GSK3β/SNAI1
autocrine
paracrine.
This
activates
program
mesenchymal
transition
epithelial,
stromal,
endothelial
cause
inflammation,
fibrosis,
stalled
endogenous
repair,
leading
organ
failure.
The
role
signalling
cell-
organ-specific
pathobiology
described,
large
unknowns
about
biology
discussed
promise
targeting
therapeutic
approach
reviewed.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(16), P. 12989 - 12989
Published: Aug. 20, 2023
Cardiac
fibrosis
is
a
common
pathological
process
in
heart
disease,
representing
therapeutic
target.
Transforming
growth
factor
β
(TGFβ)
the
canonical
driver
of
cardiac
and
was
recently
shown
to
be
dependent
on
interleukin
11
(IL11)
for
its
profibrotic
effects
fibroblasts.
In
opposite
direction,
recombinant
human
IL11
has
been
reported
as
anti-fibrotic
anti-inflammatory
mouse
heart.
this
study,
we
determined
expression
cardiomyocytes
pathobiology
function.
We
used
Cre-loxP
system
generate
tamoxifen-inducible
with
cardiomyocyte-restricted
murine
Frontiers in Medicine,
Journal Year:
2024,
Volume and Issue:
11
Published: June 14, 2024
Intestinal
fibrosis
is
a
common
complication
of
chronic
intestinal
diseases
with
the
characteristics
fibroblast
proliferation
and
extracellular
matrix
deposition
after
inflammation,
leading
to
lumen
narrowing,
structural
functional
damage
intestines,
life
inconvenience
for
patients.
However,
anti-inflammatory
drugs
are
currently
generally
not
effective
in
overcoming
making
surgery
main
treatment
method.
The
development
slow
process
its
onset
may
be
result
combined
action
inflammatory
cells,
local
cytokines,
stromal
cells.
aim
this
study
elucidate
pathogenesis
[e.g.,
(ECM),
cytokines
chemokines,
epithelial-mesenchymal
transition
(EMT),
differentiation
myofibroblast
microbiota]
underlying
explore
therapeutic
advances
(such
as
regulating
ECM,
EMT,
targeting
TGF-
β
)
based
on
order
gain
new
insights
into
prevention
fibrosis.
Clinical & Experimental Immunology,
Journal Year:
2023,
Volume and Issue:
214(2), P. 154 - 161
Published: Sept. 19, 2023
Interleukin-11
is
a
cytokine
from
the
IL-6
family
of
cytokines
that
includes
and
oncostatin-M.
Initially
described
for
its
role
in
platelet
generation,
it
now
appreciated
this
has
multiple
functions.
Recently
been
found
IL-11
critical
fibrosis
different
organ
systems
systemically
as
autoimmune
disease
systemic
sclerosis.
Animal
models
have
determined
animals
with
receptor
deletions
retarded
wild-type
at
fibrosis.
Recent
evidence
suggests
may
be
master
regulator
regardless
end
target
organ.
With
development
neutralizing
antibodies
targeting
pre-clinical
could
possible
therapeutic,
which
no
specific
therapies
exist.
This
review
appraises
tissue
fibrosis,
signalling
properties,
therapeutic
targeting.
The
ends
an
appraisal
indications
modulation
targeted.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 6, 2025
Summary
Syphilis,
caused
by
Treponema
pallidum
subsp.
pallidum,
is
an
urgent
global
public
health
threat.
Syphilis
vaccine
development
has
been
impeded
limited
understanding
of
the
molecular
mechanisms
that
enable
T.
to
establish
and
maintain
infection.
The
vascular
endothelium
critical
for
attachment,
dissemination,
host
immune
response
initiation;
however,
details
-endothelial
interactions
are
incompletely
understood.
To
enhance
understanding,
we
performed
time-course
transcriptomic
profiling
on
-exposed
brain
microvascular
endothelial
cells.
These
analyses
showed
exposure
altered
pathways
related
extracellular
matrix,
growth
factors,
integrins,
Rho
GTPases.
induced
transcriptional
was
consistent
with
mesenchymal
transition,
a
process
involved
in
fetal
dysfunction.
This
study
provides
comprehensive
responses
cells
identified
might
cause
syphilis
disease
symptoms,
information
could
aid
design.
Highlights
□
Exposure
Pallidum
significantly
alters
cell
transcriptome
Signaling
matrix
organization,
GTPases
were
overrepresented
genes
differentially
expressed
induces
factors
central
may
explain
devastating
effects
congenital
infection
expression
Snail,
main
transcription
factor
associated
transition
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Feb. 22, 2024
Fibrotic
diseases,
such
as
idiopathic
pulmonary
fibrosis
(IPF)
and
systemic
scleroderma
(SSc),
are
commonly
associated
with
high
morbidity
mortality,
thereby
representing
a
significant
unmet
medical
need.
Interleukin
11
(IL11)-mediated
cell
activation
has
been
identified
central
mechanism
for
promoting
downstream
of
TGFβ.
IL11
signaling
recently
reported
to
promote
fibroblast-to-myofibroblast
transition,
thus
leading
various
pro-fibrotic
phenotypic
changes.
We
confirmed
increased
mRNA
expression
IL11Rα
in
fibrotic
diseases
by
OMICs
approaches
situ
hybridization.
However,
the
vital
role
driver
was
not
recapitulated.
While
induction
secretion
observed
TGFβ
human
lung
fibroblasts
epithelial
cells,
cellular
responses
induced
quantitatively
qualitatively
inferior
that
at
transcriptional
translational
levels.
blocking
antibodies
inhibited
IL11Rα-proximal
STAT3
but
failed
block
TGFβ-induced
profibrotic
signals.
In
summary,
our
results
challenge
concept
blockade
strategy
providing
transformative
treatment
fibrosis.
Frontiers in Pharmacology,
Journal Year:
2023,
Volume and Issue:
14
Published: Oct. 12, 2023
Pulmonary
hypertension
(PH)
is
a
fatal
disease
caused
by
progressive
pulmonary
vascular
remodeling
(PVR).
Currently,
the
mechanisms
underlying
occurrence
and
progression
of
PVR
remain
unclear,
effective
therapeutic
approaches
to
reverse
PH
are
lacking.
Since
beginning
21st
century,
endogenous
sulfur
dioxide
(SO
2
)/aspartate
transaminase
system
has
emerged
as
novel
research
focus
in
fields
PVR.
As
gaseous
signaling
molecule,
SO
metabolism
tightly
regulated
vasculature
associated
with
development
it
involved
regulation
pathological
physiological
activities,
such
cellular
inflammation,
proliferation
collagen
metabolism,
exert
protective
effect
against
PH.
In
this
review,
we
present
an
overview
studies
conducted
date
that
have
provided
theoretical
basis
for
-related
drug
inhibit
or
effectively
treat
PH-related
diseases.