Complement Immune System in Pulmonary Hypertension-Cooperating Roles of Circadian Rhythmicity in Complement-Mediated Vascular Pathology
Hunter DeVaughn,
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Helen E. Rich,
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Anthony Shadid
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et al.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(23), P. 12823 - 12823
Published: Nov. 28, 2024
Originally
discovered
in
the
1890s,
complement
system
has
traditionally
been
viewed
as
a
"compliment"
to
body's
innate
and
adaptive
immune
response.
However,
emerging
data
have
shown
that
is
much
more
complex
mechanism
within
body
involved
regulating
inflammation,
gene
transcription,
attraction
of
macrophages,
many
processes.
Sustained
activation
contributes
autoimmunity
chronic
inflammation.
Pulmonary
hypertension
disease
with
poor
prognosis
an
average
life
expectancy
2-3
years
leads
vascular
remodeling
pulmonary
arteries;
arteries
are
essential
host
homeostasis,
they
divert
deoxygenated
blood
from
right
ventricle
heart
lungs
for
gas
exchange.
This
review
focuses
on
direct
links
between
system's
involvement
hypertension,
along
autoimmune
conditions,
reliance
processes
artery.
Furthermore,
circadian
rhythmicity
highlighted
disrupted
homeostatic
inflammatory
consequences
arteries,
which
could
potentially
open
new
therapeutic
cues.
The
current
treatment
options
discussed
clinical
trials
using
inhibitors
potential
targets
impact
cell
functions
activation,
alleviate
symptoms
block
progression
disease.
Further
research
complement's
interstitial
lung
diseases
prove
beneficial
our
understanding
these
various
prevent
arteries.
Language: Английский
NHERF2 regulatory function in signal transduction pathways and control of gene expression: Implications for cellular homeostasis and breast cancer
Adrián-Alejandro Paredes-Villa,
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Isaac Esaú Aguilar-Arce,
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Iván Meneses‐Morales
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et al.
Archives of Medical Research,
Journal Year:
2025,
Volume and Issue:
56(4), P. 103179 - 103179
Published: Jan. 14, 2025
Na⁺/H⁺
exchanger
regulatory
factor
2
(NHERF2)
is
a
nucleocytoplasmic
protein
initially
identified
as
regulator
of
membrane-bound
sodium-hydrogen
3
(NHE3).
In
the
cytoplasm,
NHERF2
regulates
activity
G
protein-coupled
receptors
(GPCRs),
including
beta-2
adrenergic
receptor
(2β-AR),
lysophosphatidic
acid
2,
and
parathyroid
hormone
type
1
receptor.
nucleus,
acts
coregulator
transcription
factors
such
sex-determining
region
Y
(SRY),
involved
in
male
sex
determination,
estrogen
alpha
(ERα).
ERα
ligand-dependent
that
controls
mammary
gland
growth
differentiation
during
puberty
pregnancy
plays
major
role
development
progression
breast
cancer
tumors.
Altogether,
functions
on
ion
channels,
GPCRs,
nuclear
have
modulatory
effect
signal
transduction
pathways,
metabolic
homeostasis,
cell
proliferation
differentiation,
neurotransmission,
muscle
contraction,
renal
electrolyte
balance.
This
work
highlights
cytoplasm
nucleus
underscores
mechanisms
through
which
participates
regulation
gene
expression
tumor
cancer.
Language: Английский
Differential associations between cytokine and complement proteins in the clinical high risk and first episode stages of psychosis: Blood based investigation across three international studies of psychosis: NEURAPRO, STEP and OPTiMiSE
Research Square (Research Square),
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 14, 2025
Abstract
Dysregulation
of
inflammatory
mediators
and
complement
cascade
proteins
has
been
implicated
in
psychosis.
In
the
current
study,
we
aimed
to
investigate
relationship
between
cytokines
blood
from
people
at
clinical
high
risk
(CHR)
for
psychosis
first
episode
(FEP).
Baseline
samples
two
cohorts
CHR
participants
[NEURAPRO
(n
=
153)
STEP
146)],
one
cohort
FEP
patients
[OPTiMiSE
226)]
were
included.
The
levels
three
Inflammatory
markers
including
Interleukin
(IL)-6,
Tumour
necrosis
factor-alpha
(TNF-α)
C-reactive
protein
(CRP)
along
with
about
30
considered
analyses.
First,
evaluated
interrelationship
then
using
regression
models,
investigated
their
association
proteins.
We
detected
positive
associations
among
all
IL-6,
TNF-α,
CRP
individuals,
whereas
was
observed
only
IL-6
TNF-α.
Regression
models
showed
strong
C3,
C4A,
C4B,
C5,
CFB
CFI
both
cohorts.
This
indicates
presence
a
related
pro-inflammatory
tone
developing
contrast,
cohort,
C1QA,
FCN-2,
MASP2
an
inverse
no
found
or
CRP.
These
results
suggest
switch
immune
activity
peripheral
circulation
compared
CHR.
novel
findings
propose
that
protein-targeted
anti-inflammatory
therapy
could
be
effective
state
hence
used
early
intervention
Language: Английский
The Clinical and Laboratory Landscape of COVID-19 During the Initial Period of the Pandemic and at the Beginning of the Omicron Era
Viruses,
Journal Year:
2025,
Volume and Issue:
17(4), P. 481 - 481
Published: March 27, 2025
Introduction:
Severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
underwent
significant
mutations,
resulting
in
the
Omicron
variant.
Methods:
In
this
study,
we
analyzed
blood
samples
from
98
patients
with
disease
19
(COVID-19)
hospitalized
during
initial
SARS-CoV-2
wave
and
onset
of
2021.
High-resolution
melting
(HRM)
analysis
PCR
products
was
used
to
analyze
RNA
extracted
clinical
collected
July
November
2021
infected
SARS-CoV-2.
Results:
HRM
revealed
a
characteristic
deletion
N
protein
virus
isolated
2021,
associated
Elevated
levels
inflammatory
markers
interleukin-6
(IL-6)
were
observed
both
waves
COVID-19.
Complement
IgG
IgM
antibodies
detected
more
often
second
wave.
An
increase
hemagglutinin-inhibiting
(HI)
against
influenza
viruses
paired
specimens
moderate
severe
COVID-19
outbreaks.
Conclusions:
Patients
admitted
showed
rise
markers,
suggesting
that
triggers
responses.
The
rapid
formation
may
indicate
faster
immune
response.
Seasonal
flu
negatively
impact
course
infections.
Language: Английский
Fibrinogen based resuscitation mitigates lung injury in mice with bacterial pneumonia after hemorrhagic shock
Feng Wu,
No information about this author
Jody Cantu,
No information about this author
Rosemary Kozar
No information about this author
et al.
Biochemistry and Biophysics Reports,
Journal Year:
2025,
Volume and Issue:
42, P. 102054 - 102054
Published: May 20, 2025
Language: Английский
Novel therapeutic receptor agonists and antagonists in allergic conjunctivitis
Current Opinion in Allergy and Clinical Immunology,
Journal Year:
2024,
Volume and Issue:
24(5), P. 380 - 389
Published: July 22, 2024
Allergic
conjunctivitis
is
characterized
by
the
development
of
pathophysiological
changes
to
ocular
surface,
which
occurs
when
pro-allergic
and
pro-inflammatory
mediators
interact
with
their
cognate
receptors
expressed
on
immune
nonimmune
cells.
Traditional
treatments
antihistamines
corticosteroids
provide
relief,
but
there
a
need
for
more
efficacious
tolerable
long-term
therapy
better
safety
profile.
This
article
aims
an
overview
mode
action
clinical
application
agonist
therapies
targeting
glucocorticoid,
melanocortin,
toll-like
receptors,
as
well
antagonist
cytokine,
chemokine,
integrin,
histamine
receptors.
Language: Английский
Neutrophil extracellular traps as immunofibrotic mediators in RA-ILD; pilot evaluation of the nintedanib therapy
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Oct. 23, 2024
Objective
Rheumatoid
arthritis-associated
interstitial
lung
disease
(RA-ILD)
is
a
significant
pulmonary
complication
of
RA.
This
study
tried
to
elucidate
the
mechanisms
enhancing
inflammation
and
causing
injury
in
RA-ILD,
focusing
on
role
neutrophil
extracellular
traps
(NETs).
The
also
investigated
potential
benefits
nintedanib
advanced
disease.
Methods
Nine
RA-ILD
patients
nine
healthy
controls
were
included
study.
Inflammatory
markers
patients’
circulation
evaluated
with
immunoassays.
formation
NETs
was
examined
using
citrullinated
histone
H3
(CitH3)
ELISA
cell
immunofluorescence.
proteins
expressed
neutrophils/NETs
studied
real-time
qPCR
NET
ELISA.
To
assess
effect
nintedanib,
an
intracellular
tyrosine
kinase
inhibitor
antifibrotic
properties,
paired
conducted
five
before
treatment
administration
16
weeks
later.
Results
soluble
terminal
complement
complex
sC5b-9
levels
CitH3
significantly
elevated
compared
controls.
In
addition,
neutrophils
isolated
from
released
enriched
tissue
factor
interleukin-17A.
had
dynamic
role,
increasing
fibrotic
human
fibroblasts
(HPFs).
On
other
hand,
decreased
patients.
Conclusion
findings
propose
interplay
between
circulating
HPFs,
establishing
immunofibrotic
aspects
RA-ILD.
They
support
effectiveness
reducing
key
pathological
processes
Further
research
needed
fully
understand
these
optimize
strategies
for
Language: Английский
Role of Complement Components in Asthma: A Systematic Review
Journal of Clinical Medicine,
Journal Year:
2024,
Volume and Issue:
13(11), P. 3044 - 3044
Published: May 22, 2024
Background:
Asthma
is
a
chronic
inflammatory
airway
disease
characterized
by
recurrent
symptoms
in
response
to
wide
range
of
external
stimuli,
including
allergens,
viral
infections,
and
air
pollution
together
with
internal
host-derived
danger
signals.
The
traditionally
associated
adaptive
immune
responses;
recent
research
emphasizes
the
critical
role
innate
immunity
its
pathogenesis.
complement
system,
activated
as
part
defense
mechanisms,
plays
crucial
bridging
immunity.
While
experimental
models
demonstrate
cascade
activation
asthma,
human
studies
remain
limited.
Methods:
This
systematic
review
summarizes
existing
literature
on
system
asthma
patients,
gathering
data
from
PubMed,
Web
Science,
Scopus,
Google
Scholar.
protocol
was
registered
OSF.
Results:
Out
482
initially
identified
articles,
only
24
met
eligibility
criteria,
revealing
disparities
sample
origin,
methodologies,
populations.
Despite
observed
heterogeneity,
consistent
result
found
elevation
regulatory
proteins,
such
Factor
H,
samples
patients
compared
those
healthy
subjects.
Conclusions:
increased
level
H
I
highlight
that
these
may
influence
pathophysiology.
factors
potential
biomarkers
activity
severity
needs
further
evaluation.
Language: Английский
A novel approach for breast cancer treatment: the multifaceted antitumor effects of rMeV-Hu191
Hereditas,
Journal Year:
2024,
Volume and Issue:
161(1)
Published: Sept. 28, 2024
Language: Английский
Transcriptome-Wide Root Causal Inference
medRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 23, 2024
ABSTRACT
Root
causal
genes
correspond
to
the
first
gene
expression
levels
perturbed
during
pathogenesis
by
genetic
or
non-genetic
factors.
Targeting
root
has
potential
alleviate
disease
entirely
eliminating
pathology
near
its
onset.
No
existing
algorithm
discovers
from
observational
data
alone.
We
therefore
propose
Transcriptome-Wide
Causal
Inference
(TWRCI)
that
identifies
and
their
graph
using
a
combination
of
variant
unperturbed
bulk
RNA
sequencing
data.
TWRCI
uses
novel
competitive
regression
procedure
annotate
cis
trans-genetic
variants
they
directly
cause.
The
simultaneously
recovers
ordering
pinpoint
underlying
estimate
effects.
outperforms
alternative
approaches
across
diverse
group
metrics
targeting
while
accounting
for
distal
relations,
linkage
disequilibrium,
patient
heterogeneity
widespread
pleiotropy.
demonstrate
uncovering
mechanisms
two
complex
diseases,
which
we
confirm
replication
independent
genome-wide
summary
statistics.
Language: Английский